Ibuprofen and Paracetamol: Relative Safety in Non-prescription Dosages

Rainsford, K. D.; Roberts, SC; Brown, S A

doi:10.1111/j.2042-7158.1997.tb06809.x

Cited by 69 publications

(67 citation statements)

References 171 publications

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“…Daily COX inhibitor consumption during resistance training resulted in an ϳ25-50% greater increase in muscle mass and strength compared with a placebo consuming group of older men and women who completed the same 12-wk resistance training program. Although over-the-counter doses of acetaminophen and ibuprofen were used in the present study, the risks associated with COX inhibitors (9,21,35) need to be considered before the use of these drugs in any population. Given the millions of individuals that consume acetaminophen, ibuprofen, and other nonprescription or prescription COX inhibitors on a regular basis, the role of this class of drugs in skeletal muscle metabolism needs to be further defined.…”

Section: Perspectives and Significancementioning

confidence: 99%

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Trappe

Carroll

Dickinson

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

160

215

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Trappe TA, Carroll CC, Dickinson JM, LeMoine JK, Haus JM, Sullivan BE, Lee JD, Jemiolo B, Weinheimer EM, Hollon CJ. Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol Regul Integr Comp Physiol 300: R655-R662, 2011. First published December 15, 2010; doi:10.1152/ajpregu.00611.2010.-Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects that resistance exercise training has on reversing sarcopenia in older adults. This study examined the influence of acetaminophen or ibuprofen consumption on muscle mass and strength during 12 wk of knee extensor progressive resistance exercise training in older adults. Thirty-six individuals were randomly assigned to one of three groups and consumed the COX-inhibiting drugs in double-blind placebo-controlled fashion: placebo (67 Ϯ 2 yr; n ϭ 12), acetaminophen (64 Ϯ 1 yr; n ϭ 11; 4 g/day), and ibuprofen (64 Ϯ 1 yr; n ϭ 13; 1.2 g/day). Compliance with the resistance training program (100%) and drug consumption (via digital video observation, 94%), and resistance training intensity were similar (P Ͼ 0.05) for all three groups. Drug consumption unexpectedly increased muscle volume (acetaminophen: 109 Ϯ 14 cm 3 , 12.5%; ibuprofen: 84 Ϯ 10 cm 3 , 10.9%) and muscle strength (acetaminophen: 19 Ϯ 2 kg; ibuprofen: 19 Ϯ 2 kg) to a greater extent (P Ͻ 0.05) than placebo (muscle volume: 69 Ϯ 12 cm 3 , 8.6%; muscle strength: 15 Ϯ 2 kg), when controlling for initial muscle size and strength. Follow-up analysis of muscle biopsies taken from the vastus lateralis before and after training showed muscle protein content, muscle water content, and myosin heavy chain distribution were not influenced (P Ͼ 0.05) by drug consumption. Similarly, muscle content of the two known enzymes potentially targeted by the drugs, COX-1 and -2, was not influenced (P Ͼ 0.05) by drug consumption, although resistance training did result in a drug-independent increase in COX-1 (32 Ϯ 8%; P Ͻ 0.05). Drug consumption did not influence the size of the nonresistance-trained hamstring muscles (P Ͼ 0.05). Over-thecounter doses of acetaminophen or ibuprofen, when consumed in combination with resistance training, do not inhibit and appear to enhance muscle hypertrophy and strength gains in older adults. The present findings coupled with previous short-term exercise studies provide convincing evidence that the COX pathway(s) are involved in the regulation of muscle protein turnover and muscle mass in humans.cyclooxygenase; prostaglandin; sarcopenia SARCOPENIA, DEFINED AS THE loss of skeletal muscle mass, is a debilitating clinical condition associated with old age (13,40). This age-related loss of muscle mass is associated with a loss of muscle strength and function, a reduced functional independence, and a financial burden to the US healthcare system estimated at $20 billion per year (19,23,24,51). One of the most proven treatments for sarcopenia is resistance exercise training, which in...

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Section: Perspectives and Significancementioning

confidence: 99%

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Trappe

Carroll

Dickinson

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

160

215

View full text Add to dashboard Cite

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“…Of these, minor gastrointestinal side effects are the most commonly reported in clinical trials, but it is notable that there are no reports in any controlled study, in adults or children, of any sign or symptom of gastrointestinal bleeding (31).…”

Section: Ibuprofen Safetymentioning

confidence: 99%

Acetaminophen and ibuprofen

1998

Paediatrics &Amp; Child Health

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“…A stock solution from each of Ibuprofen and caffeine standard was prepared (Ibuprofen: 200 ppm, Fluka PHR1004; caffeine: 50 ppm, Fluka PHR1009; Sigma-Aldrich, St. Louis, MO) and diluted further to attain desired concentrations as specified in Tables 1 and 2. The Ibuprofen concentrations were determined based on an average human having 5 liters of blood [33] and the maximum over the counter dose of 6 × 200 mg Ibuprofen tablet within 24 hours [34]. The increase in Ibuprofen concentrations was equivalent to an additional dose of 1 × 200 mg tablet.…”

Section: Treatmentsmentioning

confidence: 99%

Effects of Ibuprofen and Caffeine Concentrations on the Common Bed Bug (Cimex lectulatius L.) Feeding and Fecundity

Kamble¹

2015

Entomol Ornithol Herpetol

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Bed bugs are ectoparasites of humans and require a blood meal for their growth and reproduction. Since humans consume Ibuprofen as pain medication and drink coffee (caffeine), bed bugs are likely to acquire these drugs through blood feeding. In this study, we determined the biological effects of Ibuprofen and caffeine on bed bug feeding, fecundity and egg hatch. Five concentrations of Ibuprofen and caffeine were incorporated into reconstituted human blood (RHB). Control treatment had no Ibuprofen or caffeine. Each treatment had six replications. Groups of 20 adult bed bugs (10 males: 10 females)/treatment/replication were pre-weighed, allowed to feed for 45 minutes, and then reweighed. After feeding, bed bugs were transferred into a glass jar equipped with harborage and all the jars were placed in an environmental chamber undisturbed for three 7-day intervals to determine fecundity and nymph emergence. Ibuprofen data showed that the mean mass of the 20 adult bed bugs increased by 0.1074 g (125.65%) in the control but by 0.1336 g (157.30%) at 200 ppm after feeding. After 7 days, 306 and 146 eggs were laid by the 60 female bed bugs fed on 0 and 200 ppm Ibuprofen, respectively. After 2 weeks, 94% eggs hatched with no significant differences amongst treatments. In the caffeine experiments, the bed bug mean mass increases were 0.1219 g (163.90%) in control and 0.0790 g (104.62%) at 50 ppm caffeine. After 7 days, 264 eggs were laid by 60 female bed bugs in control but only 81 eggs were laid at the 50 ppm. Nymph emergence was >80% for all caffeine concentrations after 2 weeks. These results demonstrated that increasing Ibuprofen concentrations had positive effects on mass gain but negative effects on egg laying capacity of bed bugs. Caffeine concentrations had negative effects on bed bug feeding, fecundity and egg hatch.

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Ibuprofen and Paracetamol: Relative Safety in Non-prescription Dosages

Cited by 69 publications

References 171 publications

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Acetaminophen and ibuprofen

Effects of Ibuprofen and Caffeine Concentrations on the Common Bed Bug (Cimex lectulatius L.) Feeding and Fecundity

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