Ibudilast May Improve Retinal Circulation in Patients with Diabetes mellitus

Suzuki, Ryo; Sugihara, Itsuko; Ishibashi, Tatsuro; Kurimoto, S

doi:10.1159/000267168

Cited by 3 publications

(7 citation statements)

References 9 publications

(17 reference statements)

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“…These actions of ibudilast may have a protective effect on the progression of microangiopathy in type 2 DM subjects. Although little is known about the effect of ibudilast on diabetic microangiopathy, the present results were consistent with the report of Suzuki et al [7]or Sone et al [8]. Suzuki et al [7]suggested that ibudilast may be useful for diabetic retinopathy, since it improved retinal circulation in patients with diabetes.…”

Section: Discussionsupporting

confidence: 92%

“…Although little is known about the effect of ibudilast on diabetic microangiopathy, the present results were consistent with the report of Suzuki et al [7]or Sone et al [8]. Suzuki et al [7]suggested that ibudilast may be useful for diabetic retinopathy, since it improved retinal circulation in patients with diabetes. Sone et al [8]indicated that ibudilast is effective in ameliorating diabetic microangiopathy and macroangiopathy of the lower limbs.…”

Section: Discussionsupporting

confidence: 92%

“…This compound also demonstrates vasodilatory action [3, 4]and platelet aggregation inhibitory action [5, 6]. Suzuki et al [7]suggested that the retinal circulation in patients with diabetes was improved by ibudilast. Sone et al [8]indicated that ibudilast is effective in ameliorating diabetic microangiopathy and macroangiopathy of the lower limbs.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of Ibudilast on Urinary Albumin Excretion in Type 2 Diabetes mellitus with Microalbuminuria

Hoshino

Ikeda

2002

Nephron

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To evaluate the clinical effect of ibudilast, a prostacyclin-mediated vasodilator and antiplatelet agent, on diabetic nephropathy, 8 nonhypertensive patients with type 2 diabetes mellitus (DM; 4 men and 4 women, mean age: 58.9 ± 11.4 years, duration of diabetes: 16.9 ± 3.2 years) with microalbuminuria [20–200 mg/g creatinine (Cr)] were administered ibudilast (30 mg/day) for 18 months (ibudilast group). The urinary albumin excretion index (UAE, mg albumin/g Cr) was compared with 8 age-matched type 2 DM with microalbuminuria (control group). During the study, the UAE significantly decreased in the ibudilast group, while it significantly increased in the control group. After 18 months, the UAE (52 ± 19 mg/g Cr) in the ibudilast group was significantly (p < 0.05) lower than that (99 ± 46 mg/g Cr) in the control group. These results suggest that ibudilast may inhibit the progression of early diabetic nephropathy in type 2 DM.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of Ibudilast on Urinary Albumin Excretion in Type 2 Diabetes mellitus with Microalbuminuria

Hoshino

Ikeda

2002

Nephron

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“…Prior to registration the images were shade-corrected to remove any low-frequency intensity content such as that produced by uneven illumination of the images (Spencer 1992). This is achieved by subtracting a grossly median filtered version of the image from itself, and produces an image in which only small features such as the retinal vessels are present.…”

Section: Registrationmentioning

confidence: 99%

Quantifying changes in retinal circulation: the generation of parametric images from fluorescein angiograms

Hipwell¹,

Manivannan²,

Vieira³

et al. 1998

Physiol. Meas.

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Fluorescein angiography is an established technique for examining the functional integrity of the retinal circulation. The ability to quantify this function offers the possibility of early detection of changes due to retinopathy. We have developed a technique to generate functional, parametric images of the retinal circulation. A given angiogram is first registered to align consecutive frames. At each point in the retina, a graph of fluorescein intensity versus time is then constructed and fitted with a gamma variate curve. Parameters are extracted from these curves and formed into parametric images showing the variation in fluorescein passage across the entire area of the angiogram. Parameters examined to date include time to maximum intensity, time of arrival and rise time. The technique has been demonstrated using photographic and scanning laser ophthalmoscopic angiograms of both normal subjects and patients with a variety of retinopathies. The time to maximum images of the normal subjects reveals a similar fillings pattern in each case, whilst the pathologies present in the abnormal angiograms are clearly identified. The generation of functional time to maximum images enables the health of the retinal circulation to be quantified with respect to the rate at which the vasculature fills with fluorescein. This offers a potential tool for detecting the onset of retinopathy and monitoring its progression.

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“…21,22) A previous study demonstrated that 2-week administration of ibudilast shortened the mean retinal circulation time in patients with diabetes mellitus. 23) The results suggest that chronic treatment with ibudilast would exert beneficial effects on the retinal circulation. However, the mechanism underlying the effects remains to be established.…”

mentioning

confidence: 95%

Vasodilator Effects of Ibudilast on Retinal Blood Vessels in Anesthetized Rats

Noguchi

Mori

Sakamoto

et al. 2009

Biological & Pharmaceutical Bulletin

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Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a a]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0. 1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo.

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Ibudilast May Improve Retinal Circulation in Patients with Diabetes mellitus

Cited by 3 publications

References 9 publications

Inhibitory Effect of Ibudilast on Urinary Albumin Excretion in Type 2 Diabetes mellitus with Microalbuminuria

Inhibitory Effect of Ibudilast on Urinary Albumin Excretion in Type 2 Diabetes mellitus with Microalbuminuria

Quantifying changes in retinal circulation: the generation of parametric images from fluorescein angiograms

Vasodilator Effects of Ibudilast on Retinal Blood Vessels in Anesthetized Rats

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