Ibotenic acid lesions of the parabrachial nucleus and conditioned taste aversion: Further evidence for an associative deficit in rats.

Grigson, Patricia S.; Reilly, Steve; Shimura, Tsuyoshi; Norgren, Ralph

doi:10.1037/0735-7044.112.1.160

Cited by 84 publications

(94 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The additional CeA-projecting NST and PBN neurons recruited in rats after high TMT exposure may include glucagon-like peptide-1-positive NST neurons and CGRP-positive lateral PBN neurons that provide direct input to the CeA. In this regard, the TMT-specific activation of c-Fos expression in the external lateral PBN is consistent with the observed CFA response to TMT, because formation of both CFA and CTA requires the PBN, the CeA, and the connections between them (15,18,35,49). Our preliminary observations indicate that many of the lateral PBN neurons activated in rats after TMT exposure are CGRP positive and that c-Fos-positive CeA neurons in the same rats lie within the lateral CeA subregion region that is targeted by CGRP-positive fibers (data not shown).…”

Section: Tmt-induced Activation Of Inputs To Ceasupporting

confidence: 69%

Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats

Myers¹,

Rinaman²

2005

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Myers, Elizabeth A., and Linda Rinaman. Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats. Am J Physiol Regul Integr Comp Physiol 288: R1716 -R1726, 2005. First published January 20, 2005 doi:10.1152/ajpregu.00479.2004.-Interoceptive stimuli modulate stress responses and emotional state, in part, via ascending viscerosensory inputs to the hypothalamus and limbic forebrain. It is unclear whether similar viscerosensory pathways are recruited by emotionally salient exteroceptive stimuli, such as odors. To address this question, we investigated conditioned avoidance and central c-Fos activation patterns in rats exposed to synthetic trimethylthiazoline (TMT), an odiferous natural component of fox feces. Experiment 1 demonstrated that rats avoid consuming novel flavors that previously were paired with TMT exposure, evidence that TMT supports conditioned flavor avoidance. Experiment 2 examined central neural systems activated by TMT. Odor-naive rats were acutely exposed to low or high levels of TMT or a novel nonaversive control odor and were perfused with fixative 60 -90 min later. A subset of rats received retrograde neural tracer injections into the central nucleus of the amygdala (CeA) 7-10 days before odor exposure and perfusion. Brain sections were processed for dual-immunocytochemical detection of c-Fos and other markers to identify noradrenergic (NA) neurons, corticotropin-releasing hormone (CRH) neurons, and retrogradely labeled neurons projecting to the CeA. Significantly greater proportions of medullary and pontine NA neurons, hypothalamic CRH neurons, and CeA-projecting neurons were activated in rats exposed to TMT compared with activation in rats exposed to the nonaversive control odor. Thus the ability of TMT to support conditioned avoidance behavior is correlated with significant odor-induced recruitment of hypothalamic CRH neurons and brain stem viscerosensory inputs to the CeA. c-Fos; noradrenergic; corticotropin-releasing hormone; paraventricular nucleus of the hypothalamus; central nucleus of the amygdala; nucleus of the solitary tract; parabrachial nucleus; ventrolateral medulla STRESS AND ANXIETY RESPONSES in humans and animals include somatic, autonomic, and neuroendocrine components and can be induced by a wide variety of interoceptive and exteroceptive stimuli in natural and experimental conditions. Many researchers have sought to use ethologically relevant stress and anxiety paradigms in experimental animals to probe the central neural mediation of species-specific behavioral and physiological responses (2, 6, 9, 10, 23). For example, olfactory cues exert a powerful influence on rodent behavior; thus odors such as trimethylthiazoline (TMT) may provide a useful experimental model with which to examine stimulus-evoked behavioral and physiological responses and their central neural mediators.TMT is a volatile sulfur-containing compound isolated from fox feces. Results from behavioral studies support the view that TMT...

show abstract

Section: Tmt-induced Activation Of Inputs To Ceasupporting

confidence: 69%

Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats

Myers¹,

Rinaman²

2005

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Grigson and collaborators (Grigson et al 1998(Grigson et al , 2002Schroy et al 2005) have proposed that the treatment with drugs of abuse, such as cocaine, morphine and amphetamine, do not cause a taste aversion per se. Rather, treatment with these drugs suppresses intake of the normally preferred sucrose solution by interfering with the reinforcing aspects of the solution.…”

Section: Discussionmentioning

confidence: 99%

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Carrihill-Knoll

Rabin

Shukitt‐Hale

et al. 2007

AGE

View full text Add to dashboard Cite

Exposure to 56 Fe particles produces changes in dopaminergic function and in dopaminedependent behaviors, including amphetamine-induced conditioned taste aversion (CTA) learning. Because many of these changes are characteristic of the changes that accompany the aging process, the present study was designed to determine whether or not there would be an interaction between age and exposure to 56 Fe particles in the disruption of an amphetamine-induced CTA. One hundred and forty F-344 male rats 2-, 7-, 12-, and 16-months old, were radiated with 56 Fe particles (0.25-2.00 Gy, 1 GeV/n) at Brookhaven National Laboratory. Three days following irradiation, the rats were tested for the effects of radiation on the acquisition of a CTA produced by injection of amphetamine (3 mg/kg, i.p.). The main effect of age was to produce a significant decrease in conditioning day sucrose intake; there was no affect of age on the acquisition of the amphetamine-induced CTA. Exposing rats to 56 Fe particles disrupted the acquisition of the CTA produced by injection of amphetamine only in the 2-month-old rats. These results do not support the hypothesis of an interaction between age and exposure to 56 Fe particles in producing a disruption of amphetamine-induced CTA learning. As such, these results suggest that the aging produced by exposure to 56 Fe particles may be endpoint specific.

show abstract

“…The design was adapted from the one described by Grigson et al (16). All the behavioral testing was conducted in the rat's home cage.…”

Section: Assessment Of Ctamentioning

confidence: 99%

Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4

Baraboi

St-Pierre

Shooner

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

The aim of our study was to investigate the anorectic and brain stimulatory effects of various doses of exendin-4 (Ex-4) and to investigate the role of the vagus nerve in Ex-4-induced brain activation. A dose-related increase in c-fos mRNA expression was observed following Ex-4 administration (0.155-15.5 g/kg). Doses of Ex-4 that caused anorexia without aversive effects (0.155, 0.775 g/kg) induced c-fos expression in the hypothalamic arcuate and paraventricular (PVH; parvocellular) nuclei as well as in the limbic and brainstem structures. Doses of Ex-4 that caused aversion (1.55, 15.5 g/kg) stimulated the same regions (in a more intense way) and additionally activated the magnocellular hypothalamic structures (supraoptic nucleus and PVH magnocellular). The brain c-fos pattern induced by Ex-4 showed both similarities and differences with that induced by refeeding. Subdiaphragmatic vagotomy significantly blunted the stimulation of c-fos mRNA expression induced by Ex-4 in the nodose ganglion, the medial part of nucleus of the solitary tract, and the parvocellular division of the PVH. Pretreatment with Ex-9-39 (330 g/kg ip) impaired the neuronal activation evoked by Ex-4 in all brain regions and in the nodose ganglion. Effects of Ex-4 on hypothalamic-pituitary-adrenal axis activity were not altered by vagotomy. Results of this study demonstrate and relate the anorectic and brain stimulatory effects of aversive and nonaversive doses of Ex-4 and indicate that the activation of specific central regions induced by the peripheral administration of Ex-4 is, at least in part, dependent on the integrity of the vagus nerve.

show abstract

Ibotenic acid lesions of the parabrachial nucleus and conditioned taste aversion: Further evidence for an associative deficit in rats.

Cited by 84 publications

References 49 publications

Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats

Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4

Contact Info

Product

Resources

About