Ibotenic acid-induced lesions of the medial zona incerta decrease lordosis behavior in the female rat.

Dornan, Wayne A.; Peterson, Melissa L.; Matuszewich, Leslie; Malen, Peter

doi:10.1037/0735-7044.105.1.210

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…The IHDA neuronal system is a diverse one that comprises DA neurons in the medial zona incerta (A13) and rostral hypothalamic periventricular nucleus and their projections within and outside the hypothalamus (4,11,27). The functional role(s) played by the IHDA system has not been ascertained, although it may involve the neuroendocrine control of luteinizing hormone secretion (18,19,38), as well as sexual (10) and ingestive (43) behaviors in rats. Earlier studies (16,42) indicate that IHDA neurons behave like the NSDA and MLDA neurons in their responses to opioids, i.e., being Half of each group received injection of either OFQ (1 g icv) or vehicle in the morning on day 6 and were decapitated 60 min later.…”

Section: Discussionmentioning

confidence: 99%

Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion

Shieh¹,

Pan²

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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Effects of orphanin FQ (OFQ) on central dopaminergic (DA) neurons and serum prolactin (PRL) were examined in ovariectomized, estrogen-primed Sprague-Dawley rats. The activities of central DA neurons, including the tuberoinfundibular (TI), nigrostriatal, mesolimbic, and incertohypothalamic ones, were determined by measuring the levels of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolite of dopamine, in their projection regions in the brain by HPLC plus electrochemical detection. Intracerebroventricular administration of OFQ lowered DOPAC levels in the median eminence (ME), striatum, nucleus accumbens, and hypothalamic paraventricular nucleus in a dose (0.01-10 microg)- and time (30-90 min)-dependent manner. In contrast, OFQ increased DOPAC in the suprachiasmatic nucleus and had no effect in the periventricular nucleus. Serum PRL levels exhibited a typical inverse relationship with the activity of TIDA neurons, as determined by DOPAC levels in the ME. In the afternoon, we observed an endogenous decrease of ME DOPAC level accompanied by a PRL surge in estrogen-primed female rats. Although OFQ caused further decrease of ME DOPAC in the afternoon, it failed to augment the PRL surge level. Although pretreatment of an antisense oligodeoxynucleotide against the opioid receptor-like receptor gene had no effect on basal ME DOPAC levels in the morning or afternoon, it attenuated the afternoon PRL surge. Furthermore, it blocked the effects of exogenous OFQ on ME DOPAC and serum PRL levels, whereas the sense or missense oligodeoxynucleotide had no effect. These results indicate that OFQ and its receptors may be involved in the regulation of central DA neuronal activity and PRL secretion.

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Section: Discussionmentioning

confidence: 99%

Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion

Shieh¹,

Pan²

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Although progestin receptors were found in many dopaminergic cell groups after oestradiol treatment, we found no evidence of progestin receptor expression in dopaminergic cells of the zona incerta, consistent with previous reports in female rats (10, 11), guinea‐pigs (17) and macaques (18). The dopamine projections from the zona incerta have been studied for a role in the control of gonadotropin release necessary for ovulation (19), as well as for sexual receptivity in female rats (20). However, it is not clear if progesterone is capable of altering dopaminergic activity of the zona incerta (19–23).…”

Section: Progestin Receptor and Tyrosine Hydroxylase Expression In Thmentioning

confidence: 99%

“…The dopamine projections from the zona incerta have been studied for a role in the control of gonadotropin release necessary for ovulation (19), as well as for sexual receptivity in female rats (20). However, it is not clear if progesterone is capable of altering dopaminergic activity of the zona incerta (19–23). Even if progesterone does affect dopaminergic activity in the zona incerta, the absence of progestin receptors in dopaminergic cells suggests that it does not do this by binding to intracellular progestin receptor within these cells.…”

Section: Progestin Receptor and Tyrosine Hydroxylase Expression In Thmentioning

confidence: 99%

Immunocytochemical Investigation of Nuclear Progestin Receptor Expression within Dopaminergic Neurones of the Female Rat Brain

Lonstein

Blaustein

2004

J Neuroendocrinology

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Progesterone influences most processes involved in female reproduction, including ovulation, sexual behaviour, pregnancy, parturition, lactation and maternal behaviour. One neurotransmitter through which progesterone might regulate many of these functions is dopamine. To determine where in the brain progesterone might alter dopaminergic activity necessary for these and other processes in rats via cell nuclear progestin receptors, ovariectomized rats were injected subcutaneously with either 4 micro g oestradiol benzoate to induce high levels of hypothalamic progestin receptor expression, or oil, and perfused 48 h later. Dual-label immunocytochemistry was used to visualize cells having immunoreactivity (ir) for progestin receptors and tyrosine hydroxylase, a rate-limiting enzyme for dopamine synthesis. Many cells containing both progestin receptor-ir and tyrosine hydroxylase-ir were found throughout the periventricular hypothalamus of oestradiol-treated females. Conversely, very few cells in the hypothalamus of oil-treated controls contained progestin receptor-ir and, consequently, few dual-labelled cells were found in this group. The greatest percentage of tyrosine hydroxylase immunoreactive cells expressing progestin receptors in oestradiol-treated females was in, or near, the arcuate nucleus (A12 group), where up to 55% of tyrosine hydroxylase-expressing cells coexpressed progestin receptors. Notably, dual-labelled cells in oestradiol-treated females were also found more rostrally than previously reported, with approximately 15-20% of tyrosine hydroxylase-ir cells in the preoptic area/anterior hypothalamus (A14 group) also containing progestin receptor-ir. No dual-labelled cells were found for either group in the posterodorsal hypothalamus (A11 group), zona incerta (A13 group), retrorubral field (A8 group), ventral tegmental area (A10 group) or substantia nigra (A9 group) because little or no progestin receptor-ir was found in these sites. These data provide new information about the neural substrate where progesterone might regulate dopamine release in the preoptic area/anterior hypothalamus. Using more sensitive techniques than those used previously, they also confirm the relationship between progestin receptor and tyrosine hydroxylase in the arcuate nucleus, which could be important for the regulation of prolactin release throughout the female reproductive cycle. Additionally, although progesterone alters mesolimbic and nigrostriatal dopamine release, and the numerous behaviours that these pathways influence, these data again suggest that it does not do so via nuclear progestin receptor in dopaminergic cells of the ventral tegmental area and substantia nigra.

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“…The IHDA neuronal system comprises those dopamine neurones in the medial zona incerta (A13) and rostral periventricular hypothalamic regions (A14), and their local projections within the hypothalamus ( 41, 42). The IHDA system, specifically that in the zona incerta, may be involved in the control of LH secretion and ovulation ( 43–45), lordosis behaviour ( 46), water and food intake ( 47) in rats. We showed in this study that cysteamine significantly increased both DOPAC and dopamine concentrations in the paraventricular nucleus and A14 (Fig.…”

Section: Discussionmentioning

confidence: 99%

Stimulatory Role of Prolactin on the Development of Tuberoinfundibular Dopaminergic Neurones in Prepubertal Female Rats: Studies with Cysteamine and Somatostatin

Shieh¹,

Pan²

1999

J Neuroendocrinology

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Cysteamine, a potent depletor of prolactin and somatostatin, was used to determine the role of prolactin and somatostatin in the control of central dopamine neurones in prepubertal rats. Cysteamine (100 mg/kg, i.p., twice daily) was injected for 7, 14 or 21 days in 28-day-old Sprague-Dawley female rats in one study and for 3 days in 35-day-old rats in another. In control rats, the 3, 4-dihydroxyphenylacetic acid (DOPAC) levels in the median eminence increased threefold from day 35 to day 49, and serum prolactin concentration increased about 50%. Cysteamine lowered serum prolactin concentrations to 20%, and median eminence DOPAC and dopamine levels to 32-50% of control levels in both studies. The DOPAC levels in the nucleus accumbens and striatum were also lowered, while both DOPAC and dopamine in the paraventricular nucleus and periventricular nucleus (A14) were increased by cysteamine. A single injection of rat prolactin (0.01, 0.1 or 1 mg/kg) significantly increased DOPAC or DOPA levels in the median eminence, nucleus accumbens and striatum, but not in the paraventricular nucleus or A14 at 14 h later in 28-day old female rats or in 40-day-old rats pretreated with cysteamine. In contrast, central injection of somatostatin dose (0.001-1 microg/rat) and time (30-90 min) dependently decreased the DOPAC levels in the median eminence, paraventricular nucleus and A14 and increased those in the nucleus accumbens and striatum of adult female rats. These results indicate that serum prolactin is important for the maturation and maintenance of dopamine systems in the median eminence, nucleus accumbens and striatum, while somatostatin exhibits inhibitory and stimulatory effects on hypothalamic and midbrain dopamine systems, respectively.

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Ibotenic acid-induced lesions of the medial zona incerta decrease lordosis behavior in the female rat.

Cited by 10 publications

References 23 publications

Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion

Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion

Immunocytochemical Investigation of Nuclear Progestin Receptor Expression within Dopaminergic Neurones of the Female Rat Brain

Stimulatory Role of Prolactin on the Development of Tuberoinfundibular Dopaminergic Neurones in Prepubertal Female Rats: Studies with Cysteamine and Somatostatin

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