Ibopamine challenge testing differentiates glaucoma suspect, stable glaucoma and progressive glaucoma cases

Abstract

Background: An ibopamine challenge is a novel technique for assessing glaucoma using ibopamine, a topical drug which temporarily increases aqueous production. We aimed to determine whether change in intraocular pressure (IOP) and/or optic cup volume (OCV) during the test differentiated between glaucoma patients at different stages of disease; namely, glaucoma suspects (GS), glaucoma patients who are stable (SG) and glaucoma patients who have demonstrated rapid progression (PG).

Ibopamine challenge testing becomes negative following successful trabeculectomy surgery

“…An ibopamine challenge has not only been found to correlate with peak IOP but may also be able to demonstrate those whose glaucoma will progress in the future . By establishing that the preoperative ibopamine challenge was positive, a negative result following trabeculectomy surgery should imply that the patient's glaucoma will now stabilize.…”

“…An ibopamine challenge has not only been found to correlate with peak IOP but may also be able to demonstrate those whose glaucoma will progress in the future. [16][17][18] By establishing that the preoperative ibopamine challenge was positive, a negative result following trabeculectomy surgery should imply that the patient's glaucoma will now stabilize. In addition, when performed on a trabeculectomy patient, a positive ibopamine challenge might imply that the trabeculectomy has failed and the patient might require re-institution of topical therapy or repeat glaucoma drainage surgery.…”