Ibn Sina's <i>Canon of Medicine</i>: 11th century rules for                assessing the effects of drugs

Nasser, Mona; Tibi, Aida; Savage‐Smith, Emilie

doi:10.1258/jrsm.2008.08k040

Cited by 40 publications

(25 citation statements)

References 10 publications

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“…It is considered one of the great classics in the history of medicine and remained the most popular medical textbook in the world over the subsequent 6 centuries. 25,36,37 …”

Section: Background Infomentioning

confidence: 99%

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

Derakhshan

2016

J Evid Based Complementary Altern Med

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Most cases of chronic fissure do not respond to medical treatment. Razi and Ibn Sina were 2 of the best-known scientists of ancient Persia. The purpose of this study was to find out new scientific evidence in modern medicine about their recommendations, in order to find certain clues to conduct useful researches in the future. First, treatments of anal fissure mentioned by Razi and Ibn Sina were reviewed. Then, literature search was made in electronic databases including PubMed, Scopus, and Google Scholar. Management of anal fissure according to Razi's and Ibn Sina's practices is done based on 3 interventions: lifestyle modifications, drug treatments, and manual procedures. Almost all remedies suggested by Razi and Ibn Sina have shown their effects on fissure in ano via several mechanisms of action in many in vitro and in vivo studies; Still there is lack of human studies on the subject.

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“…It is considered one of the great classics in the history of medicine and remained the most popular medical textbook in the world over the subsequent 6 centuries. 25,36,37 …”

Section: Background Infomentioning

confidence: 99%

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

Derakhshan

2016

J Evid Based Complementary Altern Med

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“…Avicenna listed 15 different types of pain: boring, compressing, corrosive, dull, fatigue, heavy, incisive, irritant, itching, pricking, relaxing, stabbing, tearing, tension and throbbing (9, 10). …”

Section: Avicenna (Aka Pouresina or Ibnsina)mentioning

confidence: 99%

History of Anesthesia and Pain in Old Iranian Texts

2014

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“…Pythagoras’ reluctance to pass through fava bean fields, possibly contributing to his death by captors, may have been due to his recognition of his own glucose-6-phosphate dehydrogenase (G6PD) deficiency and the hemolytic anemia associated with consumption of fava beans [16,17]. Treating someone based on their body type or other constitutional factors, as is the practice in ancient Ayurveda, Chinese, Tibetan and Iranian traditional medicine systems, incorporates genetic features into treatment considerations [13–15,18,19]. Evidence-based medicine may have yet to validate some claims of traditional medicine, but these examples demonstrate that the principles of PGx and related personalized medicine were long part of medical approaches and practice.…”

Section: Historymentioning

confidence: 99%

Pharmacogenomics in Early-Phase Clinical Development

Burt

Dhillon

2013

Pharmacogenomics

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Pharmacogenomics (PGx) offers the promise of utilizing genetic fingerprints to predict individual responses to drugs in terms of safety, efficacy and pharmacokinetics. Early-phase clinical trial PGx applications can identify human genome variations that are meaningful to study design, selection of participants, allocation of resources and clinical research ethics. Results can inform later-phase study design and pipeline developmental decisions. Nevertheless, our review of the clinicaltrials.gov database demonstrates that PGx is rarely used by drug developers. Of the total 323 trials that included PGx as an outcome, 80% have been conducted by academic institutions after initial regulatory approval. Barriers for the application of PGx are discussed. We propose a framework for the role of PGx in early-phase drug development and recommend PGx be universally considered in study design, result interpretation and hypothesis generation for later-phase studies, but PGx results from underpowered studies should not be used by themselves to terminate drug-development programs.

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Ibn Sina's Canon of Medicine: 11th century rules for assessing the effects of drugs

Cited by 40 publications

References 10 publications

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

History of Anesthesia and Pain in Old Iranian Texts

Pharmacogenomics in Early-Phase Clinical Development

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