IBD and health-related quality of life — Discovering the true impact

Lönnfors, Sanna; Vermeire, Séverine; Greco, Marco; Hommes, Daan W.; Bell, Chayim; Avedano, Luisa

doi:10.1016/j.crohns.2014.03.005

Cited by 260 publications

(237 citation statements)

References 17 publications

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“…Having IBD is reported to impair work and educational performance, and this effect of the disease may reflect the difference in socio-economic status seen in women with IBD in this study. 38 Low socio-economic status has previously been reported to be associated with adverse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease in pregnancy: a population‐based study of prevalence and pregnancy outcomes

Shand

Chen

Selby

et al. 2016

BJOG

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Objective To determine the prevalence of the inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), in pregnant women and determine pregnancy and fetal/neonatal outcomes.Design Population-based cohort study.Setting New South Wales, Australia, 2001-11.Population A total of 630 742 women who delivered at ≥20 weeks of gestation.Methods Descriptive and multivariate regression analyses of perinatal data linked to hospital admission data. We compared birth outcomes of women with and without a documented diagnosis of IBD.Main outcome measures Caesarean section, severe maternal morbidity, preterm birth <37 weeks of gestation, planned preterm birth, small-for-gestational-age (birthweight <10th centile), perinatal mortality (stillbirth/neonatal death ≤28 days).Results In all, 1960 women (0.31%) with IBD, who had 2781 births (1183 UC, 1287 CD and 311 IBD-indeterminate). Women with IBD were more likely than women without IBD to have a caesarean section [41.5 versus 28.2%, adjusted risk ratio (aRR) 1.38, 95% CI 1.31-1.45], severe maternal morbidity (2.6 versus 1.6%, aRR 1.54, 95% CI 1.17-2.03), preterm birth (9.7 versus 6.6%, aRR 1.47, 95% CI 1.30-1.66), planned preterm birth (5.3 versus 2.9%, aRR 1.74, 95% CI 1.47-2.07), and their infants to be small-for-gestational-age (9.7 versus 9.5%, aRR 1.19, 95% CI 1.04-1.36). There was no evidence of a difference in perinatal mortality.Conclusion Pregnancy-associated IBD is more common than previously reported. Pregnancies complicated by IBD at or near the time of birth have significantly higher rates of adverse pregnancy outcomes than pregnancies of women without IBD.Keywords Crohn's disease, inflammatory bowel disease, population-based, pregnancy, ulcerative colitis.Tweetable abstract Increased rates preterm birth and caesarean section in women with inflammatory bowel disease.Please cite this paper as: Shand AW, Chen JS, Selby W, Solomon M, Roberts CL. Inflammatory bowel disease in pregnancy: a population-based study of prevalence and pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease in pregnancy: a population‐based study of prevalence and pregnancy outcomes

Shand

Chen

Selby

et al. 2016

BJOG

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“…The communication with employers and schools is important to patients because of the stigma associated with IBD. In a recent European study (25), 60% of IBD patients felt stressed about taking sick leave from work due to IBD, and 24% have experienced unfair comments about their performance at work from colleagues or superiors. This additional burden could be mitigated by open communication and increased awareness, helping the general population and employers better understand the impact of IBD on their colleagues and employees.…”

Section: Figure 4) Quality and Availability Of Information And Level mentioning

confidence: 99%

Living with Inflammatory Bowel Disease: A Crohn’s and Colitis Canada Survey

Becker

Grigat

Ghosh

et al. 2015

Canadian Journal of Gastroenterology and Hepatology

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BACKGROUND: Despite improvements in therapies for inflammatory bowel diseases (IBDs), patient quality of life continues to be significantly impacted.OBJECTIVE: To assess the impact of IBD on patients and families with regard to leisure, relationships, mental well-being and financial security, and to evaluate the quality and availability of IBD information.METHODS: An online survey was advertised on the Crohn’s and Colitis Canada website, and at gastroenterology clinics at the University of Alberta Hospital (Edmonton, Alberta) and University of Calgary Hospital (Calgary, Alberta).RESULTS: The survey was completed by 281 IBD patients and 32 family members. Among respondents with IBD, 64% reported a significant or major impact on leisure activities, 52% a significant or major impact on interpersonal relationships, 40% a significant or major impact on financial security, and 28% a significant or major impact on planning to start a family. Patient information needs emphasized understanding disease progression (84%) and extraintestinal symptoms (82%). There was a strong interest in support systems such as health care insurance (70%) and alternative therapies (66%). The most common source of information for patients was their gastroenterologist (70%); however, most (70%) patients preferred to obtain their information from the Crohn’s and Colitis Canada website.CONCLUSIONS: The impact of IBD on interpersonal relationships and leisure activities was significant among IBD patients and their families. Understanding the disease, but also alternative treatment options, was of high interest. Currently, there is a discrepancy between interest in information topics and their availability. Respondents reported a strong desire to obtain information regarding disease progression, especially extraintestinal symptoms.

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“…However, CD and UC remain both a cause of decreased quality of life and nearly half the patients with CD still require at least one surgical resection during disease course (5). These impairments are usually related to periods of active disease with intense severity (6).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel diseases activity in patients undergoing pelvic radiation therapy

Annède¹,

Seisen²,

Klotz³

et al. 2017

J. Gastrointest. Oncol.

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Background: Few studies with contradictory results have been published on the safety of pelvic radiation therapy (RT) in patients with inflammatory bowel disease (IBD).Methods: From 1989 to 2015, a single center retrospective analysis was performed including all IBD patients who received pelvic external beam radiation therapy (EBRT) or brachytherapy (BT) for a pelvic malignancy. Treatment characteristics, IBD activity and gastrointestinal (GI) toxicity were examined.Results: Overall, 28 patients with Crohn's disease (CD) (n=13) or ulcerative colitis (n=15) were included in the present study. Median follow-up time after irradiation was 5.9 years. Regarding IBD activity, only one and two patients experienced a severe episode within and after 6 months of follow-up, respectively.Grade 3/4 acute GI toxicity occurred in 3 (11%) patients, whereas one (3.6%) patient experienced late grade 3/4 GI toxicity. Only patients with rectal IBD location (P=0.016) or low body mass index (BMI) (P=0.012) experienced more severe IBD activity within or after 6 months following RT, respectively. Conclusions:We report an acceptable tolerance of RT in IBD patients with pelvic malignancies.Specifically, a low risk of uncontrolled flare-up was observed.

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IBD and health-related quality of life — Discovering the true impact

Abstract: The results of this survey can be used in defining strategic priorities and planning projects and awareness raising activities. The unmet needs of IBD patients can be better demonstrated and communicated to the public, health service managers and politicians.

Cited by 260 publications

References 17 publications

Inflammatory bowel disease in pregnancy: a population‐based study of prevalence and pregnancy outcomes

Inflammatory bowel disease in pregnancy: a population‐based study of prevalence and pregnancy outcomes

Living with Inflammatory Bowel Disease: A Crohn’s and Colitis Canada Survey

Inflammatory bowel diseases activity in patients undergoing pelvic radiation therapy

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