Ibandronate treatment reverses glucocorticoid-induced loss of bone mineral density and strength in minipigs

Glüer, Claus-Christian; Scholz-Ahrens, Katharina Elisabeth; Helfenstein, Andreas; Delling, G.; Timm, Wolfram; Açil, Yahya; Barkmann, Rainer; Hassenpflug, J.; Stampa, B.; Bauss, Frieder; Schrezenmeir, Jürgen

doi:10.1016/j.bone.2006.10.019

Cited by 22 publications

(22 citation statements)

References 61 publications

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“…In addition, the expression of genes expressed in osteocytes associated with bone mineralization (Dmp1 and Phex) was significantly higher at the later time points [97]. Others' animal models in GIOP have been reported: beagles [98], ewes [99], rabbits [100], pigs [101][102][103], and zebrafish [104] (Table 5).…”

Section: Experimental Models Of Giopmentioning

confidence: 89%

Glucocorticoid-Induced Osteoporosis: A Review

Bouvard

Legrand

Audran

et al. 2009

Clinic Rev Bone Miner Metab

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Glucocorticoid (GC)-induced osteoporosis is the main cause of secondary osteoporosis. Fractures, which are often asymptomatic, can occur in as many as 50% of patients receiving chronic GC therapy. GCs have direct and indirect effects on bone cells (osteoblasts, osteocytes, and osteoclasts) with a suppression of bone formation and an increased bone resorption. The management of patients exposed to GCs should include the use of the minimal effective dose of GC, general health measures, and adequate intakes of calcium and vitamin D. Bisphosphonates are nowadays largely used in GC-induced osteoporosis and teriparatide has proved its efficiency as well.

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Section: Experimental Models Of Giopmentioning

confidence: 89%

Glucocorticoid-Induced Osteoporosis: A Review

Bouvard

Legrand

Audran

et al. 2009

Clinic Rev Bone Miner Metab

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“…(41) Ovine vertebral bodies are also remarkably tall in the cervical region, (92) and it is the thoracic and lumbar vertebrae of sheep that are most grossly similar to human vertebral dimensions. (37,93) Projectional in vivo DXA measurements of vertebrae can be easily distorted in sheep because of positioning issues associated with the amount of subcutaneous fat and fleece.…”

Section: Sheepmentioning

confidence: 99%

“…(41) On this basis, Gluer (41) speculated there may be an increased propensity for trabecular perforation in the event of increased bone resorptive activity in minipigs. Such an outcome has been shown in young growing minipigs that were ovariectomized and placed on a Ca-restricted diet.…”

Section: Pigsmentioning

confidence: 99%

Review of Nonprimate, Large Animal Models for Osteoporosis Research

Reinwald

Burr

2008

Journal of Bone and Mineral Research

131

105

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Large animal models are required for preclinical prevention and intervention studies related to osteoporosis research. The challenging aspect of this requirement is that no single animal model exactly mimics the progression of this human-specific chronic condition. There are pros and cons associated with the skeletal, hormonal, and metabolic conditions of each species that influence their relevance and applicability to human physiology. Of all larger mammalian species, nonhuman primates (NHPs) are preeminent in terms of replicating important aspects of human physiology. However, NHPs are very expensive, putting them out of reach of the vast majority of researchers. Practical, cost-effective alternatives to NHPs are sought after among ungulate (porcine, caprine, and ovine) and canine species that are the focus of this review. The overriding caveat to using large lower-order species is to take the time in advance to understand and appreciate the limitations and strengths of each animal model. Under these circumstances, experiments can be strategically designed to optimize the potential of an animal to develop the cardinal features of postmenopausal bone loss and/or yield information of relevance to treatment.

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“…After 8 mo, 10 animals from the GC-short group were killed to assess the short-term effects on bone samples (GC-s), whereas the remaining 20 animals switched to another experiment with therapeutic treatments. The results of the therapeutic treatment have been published in a separate paper (16). To describe the long-term effect of GC, animals of the control group and of GC-l continued for another 7 mo before they were killed.…”

Section: Methodsmentioning

confidence: 99%