“…Therefore, these drugs are not suitable for long-term use for the treatment of bone-damaging diseases, and they may not be suitable as oral drugs either. In addition, long-term medication can cause problems such as gastrointestinal (GI) toxicity, weight loss, bone pain, low calcium levels ( Lu et al, 2016 ; Gao et al, 2017 ; Grigg et al, 2017 ; Lange et al, 2017 ; Monda et al, 2017 ). Hence, potential new drugs are urgently needed to replace existing treatment strategies due to clinically adverse effects ( Estell and Rosen, 2021 ).…”