IB-LBM study on cell sorting by pinched flow fractionation

Ma, Jingtao; Xu, Yuanqing; Tian, Fang-Bao; Tang, Xiaoying

doi:10.3233/bme-141069

Cited by 9 publications

(11 citation statements)

References 20 publications

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“…The cell is modeled as a membrane, and the equation describing the development of the forces on the membrane is 28,13 where s is the arc length coordinate, Fs(s,t) and Fb(s,t) are, respectively, the elastic forces due to the stretching and bending deformation of the membrane. In this work, Hooke's law is used to evaluate the stretching force Fs(s,t), 43,53 i.e.…”

Section: Problem Statement and Numerical Descriptionmentioning

confidence: 99%

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An IB-LBM design of a microfluidics-based cell capture system

Tang

et al. 2020

Proceedings of the Institution of Mechanical Engineers, Part C:

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The capture of cells in a microfluidic device based on U-shaped sieves is numerically investigated by the immersed boundary-lattice Boltzmann method (IB-LBM). The effects of the width of the inlet ( h), the radius of sieves ([Formula: see text]), and the radius of posts ([Formula: see text]) on the efficiency of the device on trapping cells are studied. It is found that a narrower inlet improves the capability of the device to capture cells and promotes the uniform trapping of cells. In addition, the device is not sufficiently efficient in capturing cells when the radius [Formula: see text] is small. By increasing [Formula: see text] gradually, the cells trapped in the device are found to grow up first and then decrease. This can be explained as an optimal size of apertures between posts to induce the cells to enter the sieve, and then the cells can plug up these apertures. Finally, the effects of the post size on the cell-capturing are studied. It is found that more cells can be captured as [Formula: see text] experiences a slight increase, while the capturing efficiency will not improve if continuing to increase [Formula: see text].

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Section: Problem Statement and Numerical Descriptionmentioning

confidence: 99%

“…26,27 Xu and his collaborators have studied manipulation of cells in microfluidic devices. 12,13,28,29 Tian studied a cell in a power-law shear flow. 30 Ma et al.…”

Section: Introductionmentioning

confidence: 99%

An IB-LBM design of a microfluidics-based cell capture system

Tang

et al. 2020

Proceedings of the Institution of Mechanical Engineers, Part C:

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“…1,60 Afterwards, the original IBM and its developed versions have been extensively used in heart and blood flows. 61–68 At Stokes and low Reynolds number regimes, the IBM has been extensively used to cell/particulate flows, 13,17,46,69–84 cilia 85–87 and microswimmers. 88–94 For moderate Reynolds number flows, the IBM has been applied to study filament/flag flapping, 9,11,24,27,37,95–108 insect flying and fish swimming, 11,15,24,25,44,109…”

Section: Introductionmentioning

confidence: 99%

Recent trends and progress in the immersed boundary method

Huang

Tian

2019

Proceedings of the Institution of Mechanical Engineers, Part C:

128

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The immersed boundary method is a methodology for dealing with boundary conditions at fluid–fluid and fluid–solid interfaces. The immersed boundary method has been attracting growing attention in the recent years due to its simplicity in mesh processing. Great effort has been made to develop its new features and promote its applications in new areas. This review is focused on assessing the immersed boundary method fundamentals and the latest progresses especially the strategies to address the challenges and the applications of the immersed boundary method. Various numerical examples are also presented for demonstrating the capability of the immersed boundary method, including blood flow and blood cells, flapping flag, flow around a hoverfly, turbulence flow over a wavy boundary, shock wave-induced vibration, and acoustic waves scattered by a cylinder and a sphere. The major challenges and several open issues in this field are highlighted.

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“…The IB method was proposed by Peskin (1972). It has been used together with the lattice Boltzmann method (LBM) to simulate biological flows (Ma et al, 2014;Wei et al, 2014;Gross, 2014;Dash et al, 2015;Sun and Bo, 2015). In the IB-LBM system, the effect of moving boundary is realized by spreading the stress exerted by the boundary on the fluid onto the collocated grid points near the boundary.…”

Section: Introductionmentioning

confidence: 99%

An efficient LBM-DEM simulation method for suspensions of deformable preformed particle gels

Zhou

Hou

Sun

et al. 2017

Chemical Engineering Science

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Because of the capacity of in-depth plugging and flowing diversion, the deformable preformed particle gel (PPG) is used as an effective solution to severe fluid channeling and low sweep efficiency in oil development. However, the transport, plugging and deformation of PPG are a complex issue that involves both general characteristics of particle suspension and special deformation process. In addition, the flow of deformable PPG in porous media cannot be simulated by the classical seepage flow theory based on continuum assumptions. Thus, the paper develops an efficient simulation method for suspensions of deformable PPG, which combines the discrete idea of immersed boundary (IB) for particle deformation, lattice Boltzmann method (LBM) for fluid flow, discrete element method (DEM) for particle contact and immersed moving boundary (IMB) method for the solid-fluid interaction. The improved method is first validated by matching of the transport, plugging and deformation of PPG in porous media between numerical simulations and microscopic visualization experiments. Next, the method is used to study the effect of the particle-throat diameter ratio and elastic modulus on the critical pressure gradient, which is the smallest pressure gradient for a given PPG to pass through a throat of the porous media. The results indicate that there is a good exponential relationship between the critical pressure gradient of the PPG and the particle-throat diameter ratio. The critical pressure gradient is also linearly related to the elastic modulus of PPG. Finally, a multivariate mathematical model is proposed to characterize the quantitative relationships among the critical pressure gradient, particle-throat diameter ratio and elastic modulus. The proposed model is validated by comparisons between simulation results and prediction results by the quantitative model. Thus, the model can be used as the most important parameter for macroscopic simulations of PPG flooding in large oilfield-scale projects.

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IB-LBM study on cell sorting by pinched flow fractionation

Cited by 9 publications

References 20 publications

An IB-LBM design of a microfluidics-based cell capture system

An IB-LBM design of a microfluidics-based cell capture system

Recent trends and progress in the immersed boundary method

An efficient LBM-DEM simulation method for suspensions of deformable preformed particle gels

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