Iatrogenic neutrophilic febrile dermatosis

Abudu, Boya; Foley, Sean; Kalra, Neil; Itkin, Aleksandr

doi:10.1016/j.jdcr.2019.05.025

Cited by 1 publication

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“…9 In addition, there are few drug-induced SS cases with levofloxacin and other fluoroquinolones such as ofloxacin and norfloxacin as well. 10–12 However, to the best of our knowledge, HSS associated with levofloxacin or amoxicillin has not been previously reported.…”

Section: Discussionmentioning

confidence: 88%

Drug-Induced Histiocytoid Sweet Syndrome: Two Cases With Levofloxacin and Amoxicillin–Clavulanate

Yuksek

Gönül

Gökçe

2022

The American Journal of Dermatopathology

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Histiocytoid Sweet syndrome (HSS) is an uncommon histologic variant of Sweet syndrome (SS). HSS can be distinguished from the classic SS with an infiltrate of histiocyte-like immature myeloid cells rather than dense neutrophilic infiltration, although the clinical features are similar. Previous studies have shown that the risk of hematologic malignancy is significantly higher in HSS compared with classic SS. To lesser extent, HSS is also associated with infections, inflammatory diseases, and drugs, particularly with antineoplastic agents as well. Here, we report a case of 2 patients with an abrupt onset of erythematous, tender plaques accompanied by fever, with that revealed similar histopathologic and immunohistochemical features, whom had a history of antibiotic use. Clinicopathologic correlation led to diagnosis of drug-induced HSS, associated with the use of levofloxacin and amoxicillinclavulanate, respectively. Both patients were then successfully treated with systemic corticosteroid therapy, and neither of them had recurrence during the period of 24-month follow-up.

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Section: Discussionmentioning

confidence: 88%