Iatrogenic Nerve Injuries of the Upper Extremity

Crowe, Christopher S.; Shin, Alexander Y.; Pulos, Nicholas

doi:10.2106/jbjs.rvw.22.00161

Cited by 1 publication

(2 citation statements)

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“…Nerve grafting, nerve transfers, and nerve conduits remain standard methods in nerve injury repair. [115][116][117][118][119]135,136,138 Emerging innovations such as polyethylene glycol (PEG)-mediated nerve reconstruction and the use of advanced grafting materials like autologous BMAC highlight the progress in this field. 71,79,84,89,92,103,120 However, surgical trials are in unspecified stages, underscoring the need for further transparency and updates to gauge their potential impact.…”

Section: Discussionmentioning

confidence: 99%

“…Nerve grafting, nerve transfers, and nerve conduits remain standard methods in nerve injury repair 36–94,115–119,135,136,138 . Emerging innovations such as polyethylene glycol (PEG)–mediated nerve reconstruction and the use of advanced grafting materials like autologous BMAC highlight the progress in this field 71,79,84,89,92,103,120 .…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of Registered Clinical Trials for Peripheral Nerve Injuries

Elhelali,

Tuffaha

2024

Ann Plast Surg

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Upper extremity peripheral nerve injuries (PNIs) significantly impact daily functionality and necessitate effective treatment strategies. Clinical trials play a crucial role in developing these strategies. However, challenges like retrospective data collection, reporting biases, inconsistent outcome measures, and inadequate data sharing practices hinder effective research and treatment advancements. This review aims to analyze the landscape of reporting, methodological design, outcome measures, and data sharing practices in registered clinical trials concerning upper extremity PNIs. It seeks to guide future research in this vital area by identifying current trends and gaps. A systematic search was conducted on ClinicalTrials.gov and WHO International Clinical Trials Registry Platform up to November 10, 2023, using a combination of MeSH terms and keywords related to upper extremity nerve injury. The PRISMA 2020 guidelines were followed, and the studies were selected based on predefined inclusion and exclusion criteria. A narrative synthesis of findings was performed, with statistical analysis for associations and completion rates. Of 3051 identified studies, 96 met the inclusion criteria. These included 47 randomized controlled trials, 27 nonrandomized trials, and others. Sensory objective measures were the most common primary outcomes. Only 13 studies had a data sharing plan. The analysis revealed varied intervention methods and inconsistencies in outcome measures. There was a significant association between study funding, design, and completion status, but no association between enrollment numbers and completion. This review highlights the need for standardized outcome measures, patient-centered assessments, and improved data sharing in upper extremity PNI trials. The varied nature of interventions and inconsistency in outcome measures indicate the necessity for more rigorous and transparent research practices to strengthen the evidence base for managing these injuries.

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