Iatrogenic Kaposi's Sarcoma: a Retrospective Cohort Study in an Italian Tertiary Care Centre

Brambilla, Lucia; Tourlaki, Athanasia; Genovese, Giovanni

doi:10.1016/j.clon.2017.05.008

Cited by 31 publications

(78 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different adjuvant drugs were also administered, such as azathioprine, cyclophosphamide, cyclosporine, methotrexate, rituximab and intravenous immunoglobulins. Nevertheless, beyond corticosteroids, only cyclosporine is well known to lead to KS induction or exacerbation, probably because of an activation of a latent HHV‐8 infection in genetically susceptible patients . Among patients with pemphigus‐associated KS described in the literature, six (30%) had visceral involvement.…”

Section: Discussionmentioning

confidence: 99%

“…To shed some light on this topic, we performed a retrospective study in a large cohort of patients with non‐HIV KS followed up at our centre, firstly, to assess the frequency of bullous diseases, and, secondly, to better understand the clinical features and response to treatment of the two conflicting diseases. In fact, treatment in these cases may be particularly challenging, as the corticosteroids used for the autoimmune diseases generally exacerbate KS …”

Section: Introductionmentioning

confidence: 99%

“…It is caused by the human herpesvirus 8 (HHV-8), and its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for bullous diseases. 1,2 Autoimmune bullous skin disorders are a heterogeneous group of rare diseases clinically characterized by blisters and erosions on the skin and mucous membranes. Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are the most common disorders of this group, and they are caused by autoantibodies directed against distinct adhesion molecules of the epidermis or dermoepidermal junction, respectively.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Autoimmune bullous diseases in non‐HIVKaposi's sarcoma: a retrospective study in a large cohort of patients

Tourlaki

Genovese

Guanziroli

et al. 2018

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune bullous diseases in non‐HIVKaposi's sarcoma: a retrospective study in a large cohort of patients

Tourlaki

Genovese

Guanziroli

et al. 2018

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

show abstract

“…KS may develop during rituximab treatment, which is used for severe autoimmune disorders, chronic inflammatory disorders, and prevention of organ rejection, and may regress following its cessation. [7][8] Some important data suggest that steroids substantially increase KS-related mortality, particularly in patients with AIDS. [9] Gastrointestinal KS may develop in patients with ulcerative colitis who are on steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Classic Kaposi"s Sarcoma Showing Multiple Organ Involvement: A Case Report and Brief Review of Literature

Kandemır¹

2017

TJ Oncol

View full text Add to dashboard Cite

SUMMARYKaposi's sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstitial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature.

show abstract

“…Vincristine is a natural alkaloid isolated from the plant Vinca rosea . It exerts antiblastic effects irreversibly binding to microtubules and spindle proteins and interfering with the mitotic cycle and may be used alone or in combination with other cytotoxic drugs as a systemic chemotherapeutic regimen in KS . In a previous study on 151 patients, we have demonstrated that intralesional vincristine is an effective and safe treatment for nodular lesions in classic KS …”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic intraoperative monitoring and follow‐up of Kaposi's sarcoma nodules under treatment with intralesional vincristine

Nazzaro

Genovese

Tourlaki

et al. 2018

Skin Research and Technology

Self Cite

View full text Add to dashboard Cite

Background Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few. Materials and Methods Five patients with classic KS nodules were treated with intralesional vincristine. Ultrasonographic and color Doppler assessment were performed during vincristine injection and monitoring was repeated 1 and 3 months after the procedure. Partial response was defined as a reduction of more than 50% lesion volume and reduction of the vascular signal; complete response as a resolution of lesion associated with the absence of vascular signal. Results Six KS nodules were included in the study. On ultrasonography examination, KS nodules appeared as oval or round, hypoechoic, homogeneous structures, with intralesional vascularization, more prominent in the deepest pole of the nodule. At month 1, 4 nodules achieved a complete response, while two nodules showed a partial response and were retreated with intralesional vincristine. At month 3, all lesions achieved a complete response. Conclusion Ultrasonography may be a valuable tool in assessing clinical response to intralesional vincristine therapy of cutaneous KS nodules.

show abstract

Iatrogenic Kaposi's Sarcoma: a Retrospective Cohort Study in an Italian Tertiary Care Centre

Cited by 31 publications

References 28 publications

Autoimmune bullous diseases in non‐HIVKaposi's sarcoma: a retrospective study in a large cohort of patients

Autoimmune bullous diseases in non‐HIVKaposi's sarcoma: a retrospective study in a large cohort of patients

Classic Kaposi"s Sarcoma Showing Multiple Organ Involvement: A Case Report and Brief Review of Literature

Ultrasonographic intraoperative monitoring and follow‐up of Kaposi's sarcoma nodules under treatment with intralesional vincristine

Contact Info

Product

Resources

About