Iatrogenic Artifacts in Cytology

Valente, Philip T.; Schantz, H. Daniel

doi:10.1097/01.pcr.0000065904.67484.40

Cited by 3 publications

(5 citation statements)

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“…The cytological changes associated with chemotherapy are generally similar to those seen in response to irradiation; however, the effects are present in fewer cells 81. Chemotherapeutic agents administered intravesically include triethylenethiophosphoramide (thiotepa) and mitomycin C. The cytological changes induced by these two agents are identical and include cellular enlargement with vacuolated cytoplasm and normal nuclear:cytoplasmic ratios.…”

Section: Iatrogenic Changesmentioning

confidence: 99%

“…Multinucleation and prominent nucleoli may also be noted 80. Bizarre cell shapes and amphophilic cytoplasmic staining are also features of the atypical repair type reaction that is consequent to irradiation 81. It should be noted that the cytological alterations may be present for years after the administration of radiotherapy,81 and a relevant clinical history may not always be provided.…”

Section: Iatrogenic Changesmentioning

confidence: 99%

See 1 more Smart Citation

Urine cytopathology: Challenges, pitfalls, and mimics

Thiryayi

Rana

2011

Diagnostic Cytopathology

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Urine cytopathology is a useful and noninvasive tool in the diagnosis and follow-up of urothelial neoplasia, which remains complementary to emerging molecular tests. These specimens may be challenging and there are numerous mimics and diagnostic pitfalls with which to contend. This review discusses these various entities and includes consideration of ancillary tests that may be useful in the diagnostic procedure.

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Section: Iatrogenic Changesmentioning

confidence: 99%

Section: Iatrogenic Changesmentioning

confidence: 99%

Urine cytopathology: Challenges, pitfalls, and mimics

Thiryayi

Rana

2011

Diagnostic Cytopathology

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“…Other studies also obtained similar results, where the number of artifacts in cytology was higher than cell block (10-13). This was due to Analysis of Cell Block and Cytology Specimen ...... inadequate processing techniques, including the process of specimen collection, preparation of smears, delayed fixation, and staining (14).…”

Section: Analysis Of the Number Of Artifactsmentioning

confidence: 99%

Analysis of Cell Block and Cytology Specimen Preservation from Lung Aspiration Biopsy

Poernomo

Sandhika

Budipramana

2020

JKB

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<p>Cytology smear technique is often used in Indonesia because the process is safe, simple, easy, fast, and cost effective. At present, several studies have found that smears with cell block techniques are of better quality than smears with cytology smear techniques. The aim of this study was to analyze whether the cytology smear technique can produce adequate specimens compared to cell block towards results of lung Fine Needle Aspiration Biopsy (FNAB). Lung FNAB specimens were divided into two parts: one part was processed with cytology and the other part with cell block technique. The specimens were observed under a microscope to count the number of inflammatory cells and the number of artifacts. The numbers of inflammatory cells and artifacts were scored 0-3. The inflammatory cells consisted of neutrophils, lymphocytes and plasma cells, also macrophages. The result showed no significant difference between the number of inflammatory cells in cytology and cell block (p neutrophils=0.543; p lymphocytes and plasma cells=0.192; p macrophages=0.487) in 38 samples. The artifact score comparison test result showed a significant difference between the number of artifacts in cytology and cell block (p=0.027) with more artifacts in cytology. The most common artifact in cytology was air bubble artifacts, while cell block was dominated by torn pieces artifacts. There was no significant difference between the number of inflammatory cells found in cytology and cell block techniques. Cell block technique has less artifacts than cytology, but artifacts found in cytology can be corrected so that the cytology smear technique is still an option.</p>

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“…Some of these changes are also evident in urine cytology. Regarding cytology, iatrogenic artifacts are most often related to the use of intravesical immunotherapy, chemotherapy, or radiation 2‐4 . They mostly consist of nonspecific reactive urothelial changes that should not be misinterpreted as malignant.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding cytology, iatrogenic artifacts are most often related to the use of intravesical immunotherapy, chemotherapy, or radiation. [2][3][4] They mostly consist of nonspecific reactive urothelial changes that should not be misinterpreted as malignant. More rarely, other morphologic changes showing greater specificity are present.…”

Section: Introductionmentioning

confidence: 99%