IACUC Considerations for the Use of Livestock in Translational Research

Thulin, Joseph D; Underwood, Wendy J.

doi:10.1093/ilar/ilv003

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Selection criteria have been extensively reviewed elsewhere 11 , 44 , 45 along with Institutional Animal Care and Use Committee considerations. 46–48 Beyond this, there are additional, specific concerns when developing large animal models for research in a BSL4-Ag setting.…”

Section: Study Design Considerations For Livestock Animal Models Used In Maximum Containmentmentioning

confidence: 99%

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Lewis

Pickering

2020

ILAR Journal

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Maximum-containment laboratories are a unique and essential component of the bioeconomy of the United States. These facilities play a critical role in the national infrastructure, supporting research on a select set of especially dangerous pathogens, as well as novel, emerging diseases. Understanding the ecology, biology, and pathology at the human-animal interface of zoonotic spillover events is fundamental to efficient control and elimination of disease. The use of animals as human surrogate models or as target-host models in research is an integral part of unraveling the interrelated components involved in these dynamic systems. These models can prove vitally important in determining both viral- and host-factors associated with virus transmission, providing invaluable information that can be developed into better risk mitigation strategies. In this article, we focus on the use of livestock in maximum-containment, biosafety level-4 agriculture (BSL-4Ag) research involving zoonotic, risk group 4 pathogens and we provide an overview of historical associated research and contributions. Livestock are most commonly used as target-host models in high-consequence, maximum-containment research and are routinely used to establish data to assist in risk assessments. This article highlights the importance of animal use, insights gained, and how this type of research is essential for protecting animal health, food security, and the agriculture economy, as well as human public health in the face of emerging zoonotic pathogens. The utilization of animal models in high-consequence pathogen research and continued expansion to include available species of agricultural importance is essential to deciphering the ecology of emerging and re-emerging infectious diseases, as well as for emergency response and mitigation preparedness.

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Section: Study Design Considerations For Livestock Animal Models Used In Maximum Containmentmentioning

confidence: 99%

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Lewis

Pickering

2020

ILAR Journal

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“…The animals' conventions were affirmed by the Institutional Animal Care and USA Committee (IACUC) of the University Of Maryland School Of Medicine, and the moral rules for the treatment of creatures of the International Association for the Study of Pain were followed in all analyses. [9]. RA was instigated in the Lewis rats by infusing 200 [10].…”

Section: Animals Arrangement and Ra Inductionmentioning

confidence: 99%

Effect of Boswellia on Adjuvant Induced Rheumatoid Arthritis in Experimental Animals

Hendawy

Parambi

2018

ijpm

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Arthritis is the most common systemic connective tissue disease. About 1% of the world's population is affected by RA; women are three times more often than men. Onset is most frequent between the ages of 40 and 50 years, but people of any age can be affected. Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible joints. Although the cause of rheumatoid arthritis is unknown, autoimmunity plays an important role in both its chronicity and progression.The new trend of medical treatment of rheumatoid arthritis seeks new drugs with more efficacy and fewer side effects. Since tumor necrosis factor alpha (TNF-α) as well as other cytokines act as key players in the development of arthritis.Studies in the United States and Europe have shown that their use is less common in clinical settings, but has become increasingly more in recent years as scientific evidence about the effectiveness of herbal medicine has become more widely available. The present work investigates the effect of Boswellia on Adjuvant induced RA in Experimental Animals.

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“…Selection criteria have been extensively reviewed elsewhere 11,44,45 along with Institutional Animal Care and Use Committee considerations. [46][47][48] Beyond this, there are additional, specific concerns when developing large animal models for research in a BSL4-Ag setting.…”

Section: Study Design Considerations For Livestock Animal Models Used...mentioning

confidence: 99%

Susceptibility of domestic pigs to experimental infection with ebolaviruses

Lewis

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IACUC Considerations for the Use of Livestock in Translational Research

Cited by 4 publications

References 4 publications

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Effect of Boswellia on Adjuvant Induced Rheumatoid Arthritis in Experimental Animals

Susceptibility of domestic pigs to experimental infection with ebolaviruses

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