Ia Antigens

Cullen, Susan E.; Rose, Steven; Kindle, Cathy S.

doi:10.1007/978-1-4684-3758-4_16

Cited by 3 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These functional differences between Ia-expressing cells cannot be readily attributed to differences in the rate of biosynthesis or density of Ia molecules on the membrane (1,13,14). Another explanation for the functional differences could lie in structural differences between the Ia antigens expressed on accessory cells and on B cells.…”

mentioning

confidence: 99%

“…Another explanation for the functional differences could lie in structural differences between the Ia antigens expressed on accessory cells and on B cells. In this regard, HPLC analysis of [3H]leucine-labeled tryptic peptides from a and ,B chains of I-A and I-E subregion products from both cell types has revealed no detectable differences in the proteins (14,15). However, when I-A and I-E a chains from spleen accessory cells and B cells were compared by isoelectric focusing (IEF), a glycosylation difference was noted (14).…”

mentioning

confidence: 99%

“…In this regard, HPLC analysis of [3H]leucine-labeled tryptic peptides from a and ,B chains of I-A and I-E subregion products from both cell types has revealed no detectable differences in the proteins (14,15). However, when I-A and I-E a chains from spleen accessory cells and B cells were compared by isoelectric focusing (IEF), a glycosylation difference was noted (14). On acid-range IEF gels, B-cell a chains contained bands that focused at a lower isoelectric point than accessory cell a chains.…”

mentioning

confidence: 99%

See 2 more Smart Citations

T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

Cowing¹,

Chapdelaine²

1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Previous studies have shown that the peptides obtained from accessory cell and B-cell Ta molecules are identical but that the a chains of B-cell Ia molecules are more extensively sialylated than those of accessory cells. The present studies were designed to determine whether this glycosylation difference can account for the functional difference in the capacity of the two cell types to activate alloreactive T cells. The experimental data show that normal resting B cells lack the capacity to induce DNA synthesis or differentiation in alloreactive T cells. T cells do recognize polymorphisms in B-cell Ia molecules, however, because they can be specifically primed for a subsequent proliferative stimulus of the same haplotype. The mitogenic signal for T cells is delivered by either allogeneic accessory cells or neuraminidase-treated B cells. Therefore, the T-cell receptor(s) may contain a site specific for the nonpolymorphic asialocarbohydrate moiety on the a chains of accessory cell Ia molecules.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

Cowing¹,

Chapdelaine²

1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Because the Soviet model of deviance linked any kind of 'failed behaviour' with the inability of social organizations to perform successfully their tasks of surveillance, education and persuasion, 60 the prevention of disciplinary violations, misconduct and violence, defined as the struggle for the 'moral and ideological chastity of our cadres', 61 consisted of increased ideological and political education, stateinitiated and state-sponsored cultural activities and extended state control over militiamen's family life and leisure activities.…”

Section: Re-socializing the Militia Forces: 'Struggle For Ideological And Political Chastity Of Our Cadres' 57mentioning

confidence: 99%

The Hidden Violence of Totalitarianism: Policing Soviet Society in Lithuania

Baločkaitė

2015

European History Quarterly

View full text Add to dashboard Cite

This article deals with the historical development of the militia in the Soviet Union. The discussion concentrates on the post-Stalinist era, when terror as a method of rule was largely rejected and the regime shifted towards the use of propaganda and education as a mode of governance. On the basis of archival materials, the article describes how militia activities in the Lithuanian Soviet Socialist Republic (SSR) were organized during the period 1969-1975. Particular attention is given to the attempts of the state authorities to make the militia more legitimate and acceptable to the general population, reduce the antagonism between the militia and society, decrease the amount of direct physical violence and find new, less violent and more consensual ways to police Soviet society.

show abstract

Carbohydrate Structure, Biological Recognition, and Immune Function

Reading

1984

The Biology of Glycoproteins

View full text Add to dashboard Cite

Ia Antigens

Cited by 3 publications

References 49 publications

T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

The Hidden Violence of Totalitarianism: Policing Soviet Society in Lithuania

Carbohydrate Structure, Biological Recognition, and Immune Function

Contact Info

Product

Resources

About