I2/TBHP promoted isocyanide insertion cyclization reaction for the synthesis of quinazolin fused benzoimidazole as a selective methanol detection probe

Ahmadi, Fereshteh; Ahmadi, Nafiseh; Balmohammadi, Yaser; Naimi-Jamal, Mohammad Reza; Bazgir, Ayoob

doi:10.1016/j.catcom.2021.106331

Cited by 2 publications

(2 citation statements)

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“…In 2021, the Bazgir group outlined a metal‐free, environmentally sustainable I 2 /TBHP assisted isocyanide insertion reaction for the synthesis of benzoimidazoquinazoline scaffold (Scheme 8). [25] Using a more palatable iodine molecule in place of expensive transition metal catalysts and introducing a straightforward one‐step process are the main benefits of this approach. A successful reaction between aromatic and aliphatic isocyanides with substituted benzo[ d ]imidazol‐2‐yl anilines accomplished the desired products in mild to high isolated yields.…”

Section: Various Synthetic Protocols Of Imidazo/benzimidazo[12‐c]quin...mentioning

confidence: 99%

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

Bairy,

Sinha

2024

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A great deal of attention has been received on developing N‐heterocyclic compounds due to their ambitious biological activities. Many of them are essential footstep to the development and discovery of new drugs. Imidazole/benzimidazole and quinazoline are essential pharmacologically active N‐heterocycles, and one of the molecular framework built up from their combination, imidazo/benzimidazo[1,2‐c]quinazoline, is of great attention in terms of synthesis, reactions, and medicinal applications. The positional variation of hetero N‐atoms and the functional groups acting as substituents in the main scaffold have a direct impact on the properties of imidazo/benzimidazo[1,2‐c]quinazolines. In addition to its physiological activities, this moiety is useful for electrical conductivity, molecules/ions sensing, coordination complex and coordination polymer (CP) formation, and their diverse applications. The major objective of this review is to highlight various synthetic approaches for imidazo/benzimidazo[1,2‐c]quinazolines motif since 2000. Toxicant‐free reaction conditions and the use of an extensive range of inexpensive substrates are two of the main practical benefits of the protocol in accomplishing the sustainable development goals.

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Section: Various Synthetic Protocols Of Imidazo/benzimidazo[12‐c]quin...mentioning

confidence: 99%

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

Bairy,

Sinha

2024

ChemistrySelect

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“…Use of benzoimidazoquinazoline scaffold as new solvatochromic dyes, the transition metal‐free catalysis, use of readily available starting materials, broad substrate scope, and simple experimental procedure are the key features of this work (Scheme 65). [120] …”

Section: Synthesis Of O/n‐heterocyclesmentioning

confidence: 99%

I₂/TBHP Reagent System: A Modern Paradigm for Organic Transformations**

2022

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Molecular iodine in combination with TBHP offers an advanced concept for organic synthesis and catalysis by improving the selectivity and sustainability of organic transformations. It leads to the development of metal free greener protocols under ambient conditions either as a catalytic duo or as a reagent system in combination with an additive. The advent of this indispensable tool led to formation of complex organic architectures empowering novel reaction pathways through CÀ H functionalization, cyclization, cycloaddition, rearrangement, sulfonylation/sulfenylation and oxidation reactions in organic synthesis.

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I2/TBHP promoted isocyanide insertion cyclization reaction for the synthesis of quinazolin fused benzoimidazole as a selective methanol detection probe

Cited by 2 publications

References 33 publications

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

I₂/TBHP Reagent System: A Modern Paradigm for Organic Transformations**

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I2/TBHP promoted isocyanide insertion cyclization reaction for the synthesis of quinazolin fused benzoimidazole as a selective methanol detection probe

Cited by 2 publications

References 33 publications

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines

I2/TBHP Reagent System: A Modern Paradigm for Organic Transformations**

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I₂/TBHP Reagent System: A Modern Paradigm for Organic Transformations**