<i>γδ</i>T Cells Cross-Link Innate and Adaptive Immunity in<i>Mycobacterium tuberculosis</i>Infection

Meraviglia, Serena; Daker, Sary El; Dieli, Francesco; Martini, Federico; Martino, Angelo

doi:10.1155/2011/587315

Cited by 76 publications

(71 citation statements)

References 86 publications

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“…7 Circulating γδ T cells are increased in active TB and LTBI. The IFN-γ production in response to BrHPP was used to measure γδ T cell activation.…”

Section: Discussionmentioning

confidence: 99%

“…Non-classical T cells, such as CD1 restricted and Vδ2+ T cells (γδ T cells), recognize MTB and bridge innate and adaptive responses. [4][5][6][7] These different immune responses are measurable with whole blood assays using specific ligands to elicit cytokine production. Overnight tumor necrosis factor α (TNF-α) production in response to ligands for TLR2, TLR4, and interferon gamma receptor (IFN-γR) measures innate responses.…”

Section: Introductionmentioning

confidence: 99%

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Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

Mahan¹,

Zalwango²,

Thiel³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Contacts of active pulmonary tuberculosis (TB) patients are at risk for Mycobacterium tuberculosis (MTB) infection. Because most infections are controlled, studies during MTB infection provide insight into protective immunity. We compared immune responses of adult household contacts that did and did not convert the tuberculin skin test (TST). Innate and adaptive immune responses were measured by whole blood assay. Responses of TST converters (TSTC) were compared with persistently TST negative contacts (PTST–) and contacts who were TST+ at baseline (TST+). TLR-2, TLR-4, and IFN-γR responses to IFN-γ did not differ between the groups, nor did γδ T cell responses. T cell responses to MTB antigens differed markedly among TSTC, PTST–, and TST+ contacts. Thus, no differences in innate responses were found among the three household contact groups. However, adaptive T cell responses to MTB antigens did differ before and during MTB infection among PTST–, TSTC, and TST+ contacts.

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“…7 Circulating γδ T cells are increased in active TB and LTBI. The IFN-γ production in response to BrHPP was used to measure γδ T cell activation.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

Mahan¹,

Zalwango²,

Thiel³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…These subtypes of γδ T cells typically possess functional heterogeneity, and different subtypes generally influence inflammation through different pathways [14,18]. The role of γδ T cells in the pathogenesis of chronic inflammatory airway disease, such as pulmonary tuberculosis, asthma, and allergic rhinitis, has been emphasized in recent years, indicating that γδ T cells can migrate to the mucosa of both the upper and lower airways and play an important role in inflammatory diseases [20,21,22]. Due to their unique characteristics, it is necessary to explore whether γδ T cells play a part in the pathogenesis of CRS.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Analysis of γδ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps

Lee

Chang²,

Huang³

et al. 2017

ORL

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Background/Aims: To examine whether γδ T cell is expressed in the nasal mucosa of chronic rhinosinusitis (CRS) patients and its potential association with recurrence of nasal polyps. Methods: Thirty-six patients with CRS with nasal polyps (CRSwNP) and 25 patients with CRS without nasal polyps (CRSsNP) were recruited. Twenty-six patients with other nasal diseases served as controls. The CRSwNP group was divided into the eosinophilic CRSwNP and noneosinophilic CRSwNP groups. The expression of γδ T cells was detected by immunohistochemistry. The expression of each subtype of γδ T cells was detected by using qRT-PCR. All patients underwent nasal endoscopy, and postoperative follow-up lasted over 12 months. CRS patients were evaluated by preoperative VAS scores of symptoms and nasal endoscopy Lund-Kennedy scores. Results: The expression of γδ T cells in the CRSwNP groups was stronger than in the CRSsNP and the control group (p < 0.05, p < 0.05). The expression of Vγ1⁺γδ T cells in the eosinophilic CRSwNP group was higher than that in the CRSsNP group and the control group (p < 0.05, p < 0.05). The expression of γδ T cells was associated with high rate of recurrence, tissue eosinophil infiltration, worse symptom score of nasal obstruction, and higher Lund-Kennedy score (all p < 0.05). Conclusions: Increased expression of γδ T cells in CRSwNP may be associated with recurrence of nasal polyps.

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“…gd T cells are particularly recognized for their ability to respond to Mycobacterium; both human and murine gd T cells proliferate and secrete cytokines in recall response to protein and nonprotein phosphoantigens of M. tuberculosis (5,6) and expand significantly in patients with active TB (7)(8)(9). Mice deficient in gd T cells exhibit significantly larger and less-organized granulomas following infection with Mycobacterium (10, 11), suggesting a role for granuloma formation.…”

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confidence: 99%

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

McGill

Sacco

Baldwin

et al. 2014

The Journal of Immunology

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Promoting effective immunity to Mycobacterium bovis infection is a challenge that is of interest to the fields of human and animal medicine alike. We report that γδ T cells from virulent M. bovis–infected cattle respond specifically and directly to complex, protein, and nonprotein mycobacterial Ags. Importantly, to our knowledge, we demonstrate for the first time that bovine γδ T cells specifically recognize peptide Ags derived from the mycobacterial protein complex ESAT6:CFP10 and that this recognition requires direct contact with APCs and signaling through the T cell Ag receptor but is independent of MHC class I or II. Furthermore, we show that M. bovis infection in cattle induces robust IL-17A protein responses. Interestingly, in contrast to results from mice, bovine CD4 T cells, and not γδ T cells, are the predominant source of this critical proinflammatory mediator. Bovine γδ T cells are divided into subsets based upon their expression of Workshop Cluster 1 (WC1), and we demonstrate that the M. bovis–specific γδ T cell response is composed of a heterogeneous mix of WC1-expressing populations, with the serologically defined WC1.1+ and WC1.2+ subsets responding in vitro to mycobacterial Ags and accumulating in the lesions of M. bovis–infected animals. The results described in this article enhance our understanding of γδ T cell biology and, because virulent M. bovis infection of cattle represents an excellent model of tuberculosis in humans, contribute to our overall understanding of the role of γδ T cells in the mycobacterial-specific immune response.

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γδT Cells Cross-Link Innate and Adaptive Immunity inMycobacterium tuberculosisInfection

Cited by 76 publications

References 86 publications

Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

A Retrospective Analysis of γδ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

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γδT Cells Cross-Link Innate and Adaptive Immunity inMycobacterium tuberculosisInfection

Cited by 76 publications

References 86 publications

Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

A Retrospective Analysis of &#x03B3;δ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

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A Retrospective Analysis of γδ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps