<i>β</i>-cyclodextrin mediated synthesis of indole derivatives: reactions of isatins with 2-amino(or 2-thiole)anilines by supramolecular catalysis in water

Shivhare, Km Neha; Siddiqui, I. R.

doi:10.1080/10610278.2018.1529315

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…Based on the above data and the reports documented in the literature [29][30][31][32], a plausible reaction mechanism is proposed in Scheme 2. First, OPD is included in the cavity of β-CD to form the OPD-β-CD inclusion complex.…”

Section: Resultsmentioning

confidence: 75%

“…Then, the first Schiff base reaction takes place, removing a mole of water to form intermediate 3 [31]. The generated intermediate 3 is immediately oxidized by oxygen in the air to form the intermediate 4, leading to the second Schiff base reaction [32]. The presence of intermediates 3 and 4 was confirmed by high-resolution mass spectrometry (HRMS).…”

Section: Resultsmentioning

confidence: 97%

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Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

et al. 2022

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An efficient, mild, and green method was developed for the synthesis of indeno[1,2-b]quinoxaline derivatives via o-phenylenediamine (OPD) and 2-indanone derivatives utilizing β-cyclodextrin (β-CD) as the supramolecular catalyst. The reaction can be carried out in water and in a solid state at room temperature. β-CD can also catalyze the reaction of indan-1,2-dione with OPD with a high degree of efficiency. Compared to the reported methods, this procedure is milder, simpler, and less toxic, making it an eco-friendly alternative. In addition, the β-CD can be recovered and reused without the loss of activity.

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 97%

Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

et al. 2022

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Thiourea Dioxide Catalyzed Sustainable Synthesis of Diverse Quinoxaline and Pyrazine Derivatives in Aqueous Medium at Ambient Temperature

Saini,

Manju,

Raigar

et al. 2024

ChemistrySelect

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An eco‐conscious, metal‐free protocol has been developed to synthesize a diverse collection of biologically and pharmacologically active quinoxaline and pyrazine derivatives. The protocol involves a one‐pot condensation of various 1,2‐diamines with 1,2‐diones using thiourea dioxide as a catalyst and water as a solvent at ambient temperature. Notably, the catalyst can be reused up to five times without any significant loss of efficacy. The green aspects of this method involved milder reaction conditions, higher yields with shorter reaction times, simple work‐up, non‐chromatographic separations, good reusability, and easy catalyst recovery by simple filtration. Moreover, the reaction is successfully accelerated to a multigram scale, making it favourable for production at a larger scale.

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Green synthesis of isatin-based compounds

Sadeghian

Bayat²

2022

Res Chem Intermed

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β-cyclodextrin mediated synthesis of indole derivatives: reactions of isatins with 2-amino(or 2-thiole)anilines by supramolecular catalysis in water

Cited by 8 publications

References 42 publications

Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

Thiourea Dioxide Catalyzed Sustainable Synthesis of Diverse Quinoxaline and Pyrazine Derivatives in Aqueous Medium at Ambient Temperature

Green synthesis of isatin-based compounds

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