β‐Cyclodextrin and Its Derivatives Functionalized Magnetic Nanoparticles for Targeting Delivery of Curcumin and Cell Imaging

Abstract

β‐Cyclodextrin (β‐CD) and its derivatives functionalized magnetic nanoparticles (MNPs) with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxypropyl/sulfobutyl ether‐β‐CD‐MNPs (CM/HP/SBE‐β‐CD‐MNPs) nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as‐prepared nanocarriers for the hydrophobic anti‐cancer drug curcumin was also investigated. The results revealed that the SBE‐β‐CD‐MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE‐β‐CD‐MNPs entered into the cell, and curcumin could be successfully delivered into the cell by SBE‐β‐CD‐MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE‐β‐CD‐MNPs were non‐toxic, while curcumin loaded SBE‐β‐CD‐MNPs showed high potential to kill the HepG2 cells. The as‐prepared magnetic composites were expected to expand their potential applications in biomedical field.

Fabrication of Curcumin‐Modified TiO2 Nanoarrays via Cyclodextrin Based Polymer Functional Coatings for Osteosarcoma Therapy

“…The early burst release was primarily ascribed to desorption of CUR molecules loaded on the modified Ti sample by surface‐binding or physical adsorption. The controlled release of CUR molecules from pCD‐modified TiO 2 nanoarray constructs could be explained by the formation of inclusion complexes . As shown in Figure B, the OH···O bond interactions between the enolic OH of CUR and the OH group of pCD maintained the gradual release of the CUR drugs entrapped into the pCD cavities.…”

Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin†

“…[ 8‐9 ] The formation of curcumin‐loaded nano systems has proven to be effective in enhancing drug delivery efficiency. [ 10‐13 ] However, most drug carriers of these nano formulations lack intrinsic antimicrobial activity, thus failing to display the synergistic antimicrobial effect with drugs encapsulated. [ 14 ] Therefore, a promising alternative may be dual‐functional drug carriers with intrinsic therapeutic activity and synergistic effects with the drugs loaded.…”

Design of cyclodextrin-based systems for intervention execution

“…When CDs are incorporated into the design of a carrier, sometimes this is driven by the wish of taking advantage of the ability of CDs for hostÀguest complexation, either for improving the targeting specificity of the system [71] or for loading chemical drugs into the carrier for gene/ drug codelivery [72]. To optimize the structure of these modified carriers, which need to make use of the complexation capacity of CDs, we need to understand properly the electrostatic potentials inside the CD cavity as well as the molecular interactions during inclusion complexation.…”