The title molecule, C12H12N2O6, features an E conformation about the oxime group. The methoxyimino and ester residues are effectively coplanar with each other (r.m.s. deviation for the nine non-H atoms = 0.127 Å) and almost orthogonal [with dihedral angles of 99.44 (13) and −77.85 (13)°, respectively] to the carbonyl and nitrophenyl groups which lie to either side of this central plane. The crystal structure is consolidated by C—H⋯O contacts.