(Z)-2-(5-Fluoro-2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide

Abstract

The title compound, C15H11FN4OS, crystallizes with three independent mol­ecules (A, B and C) in the asymmetric unit. The dihedral angles between the nine-membered 5-fluoro­indolin-2-one ring system and the benzene ring are 22.14 (11), 12.56 (11) and 3.70 (11)° in mol­ecules A, B and C, respectively. In all three mol­ecules, intra­molecular cyclic N—H⋯O and C—H⋯S hydrogen-bonding inter­actions [graph set S(6)] are present in the N—N—C—N chain between the ring systems. In the crystal, the A mol­ecules form centrosymmetric cyclic dimers through inter­molecular N—H⋯O hydrogen bonds, which are linked into a supramolecular chain along [100] via C—H⋯F interactions; each type of hydrogen bond has graph set graph set R 2 2(8). A similar chain stabilised by similar interactions and also along [100] but, comprising alternating molecules of B and C is found. The latter chains are connected via C—H⋯S interactions, forming a layer with a zigzag topology parallel to (001).

Synthesis, structure and in vitro anticancer, DNA binding and cleavage activity of palladium (II) complexes based on isatin thiosemicarbazone derivatives

“…Schiff base ligands (L1H to L6H) were prepared as previously reported . Palladium(II) chloride was purchased from Aldrich Chemicals.…”

(Z)-2-(5-Chloro-2-oxoindolin-3-ylidene)-N-methylhydrazinecarbothioamide

“…Biological properties of isatin and its derivatives include a range of actions in the brain, offer protection against bacterial (Suryavanshi & Pai, 2006) and fungal infections and possess anticonvulsant, anti-HIV (Pandeya et al, 1999), anti-depressant and anti-inflammatory activities (Bhandari et al, 2008). Recently, we reported the crystal structure of (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-methylhydrazinecarbothioamide (Qasem Ali et al, 2012). In the present paper we describe the single-crystal X-ray diffraction study of title compound, C 10 H 9 ClN 4 OS ( Fig.…”

“…For related structures, see: Qasem Ali et al (2012Ali et al ( , 2011a; Ali et al (2012). For various biological activities of Schiff bases, see: Bhandari et al (2008); Bhardwaj et al (2010); Pandeya et al (1999); Sridhar et al (2002); Suryavanshi & Pai (2006).…”

(Z)-2-(2-Oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide

“…For related crystal structures, see: Ali et al (2012); Qasem Ali et al (2011a,b); Ferrari et al (2002); Pervez et al (2010); Ramzan et al (2010). For various biological activities of Schiff bases, see: Bhandari et al (2008); Bhardwaj et al (2010); Pandeya et al (1999); Sridhar et al (2002); Suryavanshi & Pai (2006).…”