<i>Work Capacity After Blood Donation</i>

Balke, Bruno; Grillo, G. P.; Konecci, E. B.; Luft, Ulrich C.

doi:10.1152/jappl.1954.7.3.231

Cited by 72 publications

(47 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar findings have been shown by a number of different authors including Balke et al (9% decrease in

{\overset{V}{true} normalO}_{2 \max}

1 h after a 500-mL venesection) [34], Woodson and colleagues (16% decline in

{\overset{V}{true} normalO}_{2 \max}

after 34% reduction of [Hb]) [35], Kanstrup and Ekblom (9% reduction in

{\overset{V}{true} normalO}_{2 \max}

and 40% lower endurance time at the intensity eliciting

{\overset{V}{true} normalO}_{2 \max}

after reducing [Hb] by 11% through the removal of 900 mL blood) [36] and to a lesser extent by Rowell et al (4% decrease in

{\overset{V}{true} normalO}_{2 \max}

following a 14% decrease in circulating [Hb] after repeated phlebotomies totaling 700–1,000 mL over 5 days) [37]. …”

Section: Reviewsupporting

confidence: 90%

See 1 more Smart Citation

Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome

Otto¹,

Montgomery

Richards³

2013

Extrem Physiol Med

View full text Add to dashboard Cite

The ability of the cardiorespiratory system (heart, lungs, blood) to deliver oxygen to exercising skeletal muscle constrains maximum oxygen consumption )(normalVtrue˙O2max, with cardiac output and the concentration of oxygen-carrying haemoglobin ([Hb]) being key limiting parameters. Total blood volume (BV) is the sum of the plasma volume (PV) and the total red cell volume. The measured [Hb] is dependent upon the total circulating mass of haemoglobin (tHb-mass) and plasma volume (PV). While the proportion of oxygen carried in plasma is trivial (0.3 mL of oxygen per 100 mL of plasma), each gram of Hb, contained in red blood cells, binds 1.39 mL of oxygen. As a result, the relationship between trueV˙normalO2max and tHb-mass is stronger than that observed between trueV˙normalO2max and [Hb] or BV. The glycoprotein hormone erythropoietin drives red cell synthesis and, like simple transfusion of packed red blood cells, can increase tHb-mass. An iron-containing haem group lies at the centre of the Hb molecule and, in situations of actual or functional iron deficiency, tHb-mass will also rise following iron administration. However achieved, an increase in tHb-mass also increases circulating oxygen-carrying capacity, and thus the capacity for aerobic phosphorylation. It is for such reasons that alterations in trueV˙normalO2max and exercise performance are proportional to those in arterial oxygen content and systemic oxygen transport, a change in tHb-mass of 1 g being associated with a 4 mL · min−1 change in trueV˙normalO2max. Similarly, trueV˙normalO2max increases by approximately 1% for each 3 g · L−1 increase in [Hb] over the [Hb] range (120 to 170 g · L−1). Surgery, like exercise, places substantial metabolic demands on the patient. Whilst subject to debate, oxygen supply at a rate inadequate to prevent muscle anaerobiosis may underpin the occurrence of the anaerobic threshold (AT), an important submaximal marker of cardiorespiratory fitness. Preoperatively, cardiopulmonary exercise testing (CPET) can be used to determine AT and peak exertional oxygen uptake (trueV˙normalO2 peak) as measures of ability to meet increasing oxygen demands. The degree of surgical insult and the ability to meet the resulting additional postoperative oxygen demand appear to be fundamental determinants of surgical outcome: individuals in whom such ability is impaired (and thus those with reduced trueV˙normalO2 peak and AT) are at greater risk of adverse surgical outcome. This review provides an overview of the relationships between [Hb], tHb-mass, exercise capacity, and surgical outcome and discusses the potential value of assessing tHb-mass over [Hb].

show abstract

“…Similar findings have been shown by a number of different authors including Balke et al (9% decrease in

{\overset{V}{true} normalO}_{2 \max}

1 h after a 500-mL venesection) [34], Woodson and colleagues (16% decline in

{\overset{V}{true} normalO}_{2 \max}

after 34% reduction of [Hb]) [35], Kanstrup and Ekblom (9% reduction in

{\overset{V}{true} normalO}_{2 \max}

and 40% lower endurance time at the intensity eliciting

{\overset{V}{true} normalO}_{2 \max}

after reducing [Hb] by 11% through the removal of 900 mL blood) [36] and to a lesser extent by Rowell et al (4% decrease in

{\overset{V}{true} normalO}_{2 \max}

following a 14% decrease in circulating [Hb] after repeated phlebotomies totaling 700–1,000 mL over 5 days) [37]. …”

Section: Reviewsupporting

confidence: 90%

“…Each data point represents the mean of each study using data obtained during the first 48 h after [Hb] manipulation. Figure reproduced with permission from [33] using data from nine studies [14-18,34-37]. …”

Section: Reviewmentioning

confidence: 99%

Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome

Otto¹,

Montgomery

Richards³

2013

Extrem Physiol Med

View full text Add to dashboard Cite

show abstract

“…It is broadly accepted that maximal oxygen uptake and endurance performance is closely correlated to the oxygen‐carrying capacity of the blood . In line with this we observed that peak oxygen uptake and B‐Hb concentration remained below baseline until 28 days after the blood donation, which is in contrast to our hypothesis, and former published data in men, that this would be back to baseline after 14 days.…”

Section: Discussionsupporting

confidence: 79%

Temporary impact of blood donation on physical performance and hematologic variables in women

et al. 2017

View full text Add to dashboard Cite

show abstract

“…walking speed and the distribution of longest non-stop walking distance in the days after blood donation. There is evidence that blood donation - typically corresponding to a loss of roughly 10% of the total blood volume needing several weeks to be replaced - is linked to a decrease in endurance capacity, physiologically explained by a decrease of the total number of erythrocytes that are responsible for continuous supply of oxygen to the slow-twitch muscles fibres [35]. We believe that the effect is rather small leading to a potential small bias towards lower speeds and smaller distances.…”

Section: Discussionmentioning

confidence: 85%

Association between Walking Speed and Age in Healthy, Free-Living Individuals Using Mobile Accelerometry—A Cross-Sectional Study

et al. 2011

View full text Add to dashboard Cite

ContextWalking speed is a fundamental parameter of human motion and is increasingly considered as an important indicator of individuals' health status.ObjectiveTo evaluate the relationship of gait parameters, and demographic and physical characteristics in healthy men and women.Design, Setting, and ParticipantsRecruitment of a subsample (n = 358) of male and female blood donors taking part in the Cambridge CardioResource study. Collection of demographic data, measurement of physical characteristics (height, weight and blood pressure) and assessment of 7-day, free-living activity parameters using accelerometry and a novel algorithm to measure walking speed. Participants were a median (interquartile range[IQR]) age of 49 (16) years; 45% women; and had a median (IQR) BMI of 26 (5.4).Main Outcome MeasureWalking speed.ResultsIn this study, the hypothesis that walking speed declines with age was generated using an initial ‘open’ dataset. This was subsequently validated in a separate ‘closed’ dataset that showed a decrease of walking speed of −0.0037 m/s per year. This is equivalent to a difference of 1.2 minutes, when walking a distance of 1 km aged 20 compared to 60 years. Associations between walking speed and other participant characteristics (i.e. gender, BMI and blood pressure) were non-significant. BMI was negatively correlated with the number of walking and running steps and longest non-stop distance.ConclusionThis is the first study using accelerometry which shows an association between walking speed and age in free-living, healthy individuals. Absolute values of gait speed are comparable to published normal ranges in clinical settings. This study highlights the potential use of mobile accelerometry to assess gait parameters which may be indicative of future health outcomes in healthy individuals.

show abstract

Work Capacity After Blood Donation

Cited by 72 publications

References 0 publications

Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome

Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome

Temporary impact of blood donation on physical performance and hematologic variables in women

Association between Walking Speed and Age in Healthy, Free-Living Individuals Using Mobile Accelerometry—A Cross-Sectional Study

Contact Info

Product

Resources

About