WlsProvides a New Compartmental View of the Rhombic Lip in Mouse Cerebellar Development

Abstract

Math1 is the defining molecule of the cerebellar rhombic lip and

A Novel and Multivalent Role of Pax6 in Cerebellar Development

“…Pax6 and the molecular underpinnings of cerebellar development RL precursors express Pax6 and Atoh1 (Yeung et al, 2014). The knock-out of Atoh1 results in the loss of Pax6 expression and eliminates all cerebellar glutamatergic neurons (Machold and Fishell, 2005;Englund et al, 2006;Fink et al, 2006).…”

“…In fact, earlier work found that Atoh1 ϩ cells rapidly emigrate from the RL and withdraw from the RL progenitor pool (Machold and Fishell, 2005). Based on our recent analysis of compartmentation in the RL, we speculated that another population of cells (those originating from the interior face of the RL; Wls ϩ /Pax6 ϩ cells) served to replenish the RL progenitor pool (Yeung et al, 2014). With Pax6 absent, a depletion of the neural progenitor pool has been described in the development of retina and cortex, as a result of precocious cell-cycle exit (Farhy et al, 2013) or shorter cell-cycle length (EstivillTorrus et al, 2002).…”

“…One brain region that has early and compartmental expression of Pax6, but has escaped the detection of a seminal role in development, is the cerebellum. However, in our recent work with Pax6, we have identified a transition of molecular identity in the Pax6-null cerebellum (Yeung et al, 2014), which prompted a reexamination of Pax6 and early development of the cerebellum.…”

Proliferating cells in the adult primate cerebellar cortex after ischemia

“…Crucial cellular and molecular mechanisms are established mainly by the mouse cerebellum (11,13,14). Regional expression of transcription factors in the cerebellar rhombic lip and ventricular zone shapes the fate of the hindbrain neuroepithelial stem cells of the developing cerebellum (5,9,10,17,19). Developmental defects of the cerebellum are considered in relation to selected human neurological disorders (1).…”

“…It is widely applied in studying neurogenesis, including the cerebellum (14,16,19). We examined the number, distribution and some phenotypes of newly generated cells in various cortical layers of the adult primate cerebellum after global brain ischemia with different duration.…”