WDR3Gene Haplotype Is Associated with Thyroid Cancer Risk in a Spanish Population

Abstract

These results indicate for the first time that WDR3 is a risk factor to thyroid cancer, suggesting its implication in the etiology of thyroid cancer.

Possible Role of the WDR3 Gene on Genome Stability in Thyroid Cancer Patients

“…Previous studies conducted by our group in this region have found that the WDR3 gene, mapped in this region, shows a significant association with DTC, suggesting its implication in the aetiology of thyroid cancer [3].…”

“…Aiming to find a reasonable explanation for the association observed between WDR3 polymorphisms and DTC incidence, we have already reported the up-regulation of WRD3 in different thyroid cancer cell lines, suggesting its possible implication in thyroid cancer tumorigenesis [3]. This would agree with the studies carried out in the breast carcinoma cell line MCF-7 showing that the suppression of WDR3 reduce cell proliferation, decrease cell size and reduce foci formation, indicating that WDR3 confers a growth and proliferative advantage on cancer cells [8].…”

“…The polymorphisms used in this study were selected according to our previous analyses [3]. Thus, we selected three tag SNPs showing haplotype association with thyroid cancer, rs3754127 (C/T, 5′ near gene), rs3765501 (G/A, intron) and rs4658973 (T/G, intron).…”

Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk

“…Interestingly, these regions contain thyroid differentiation genes FOXE1 and NKX2-1, respectively (4,5). Additional polymorphisms at 5q33 and 1p12 are also susceptibility loci for thyroid cancer (6,7), and more recently, the WDR3 gene that maps at 1p12 was found to be associated with the disease (8). In chromosome 8q24, three independent regions have been related to risk of different types of cancers, including thyroid cancer, but no known genes reside in that susceptibility region (9,10).…”

A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population

“…In recent times, several genetic studies have reported relationship between PTC and candidate genes, such as WD repeat domain 3 (WDR3) (25), vascular endothelial growth factor A (VEGFA) (26), RAD52 homolog (S. cerevisiae) (RAD52) (27), protein tyrosine phosphatase, receptor type, J (PTPRJ) (28), purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7) (29), interleukin 6 (interferon, beta 2; IL6) (30), IL10 (31) and IL11 (32). …”