“I Was a Little Surprised”: Qualitative Insights From Patients Enrolled in a 12-Month Trial Comparing Opioids With Nonopioid Medications for Chronic Musculoskeletal Pain
Abstract:SPACE trial results indicated no advantage for opioid over nonopioid medications. Qualitative findings suggest that, for both treatment groups, preexisting expectations and anticipated improvement in pain shaped experiences with and responses to medications. The personalized pain care model was described as contributing to positive outcomes in both groups.
“…[ [37][38][39][40] The major strengths of this study include the large national sample, good survey response rate, and linkage to high-quality EMR and pharmacy dispensing data. This study also has limitations.…”
In the United States (US), long-term opioid therapy has been commonly prescribed for chronic pain. Since recognition of the opioid overdose epidemic, clinical practice guidelines have recommended tapering long-term opioids to reduced doses or discontinuation. The Effects of Prescription Opioid Changes for veterans (EPOCH) study is a national population-based prospective observational study of US Veterans Health Administration primary care patients designed to assess effects of evolving opioid prescribing practice on patients treated with long-term opioids for chronic pain. A stratified random sampling design was used to identify a survey sample from the target population of patients treated with opioid analgesics for � 6 months. Demographic, diagnostic, visit, and pharmacy dispensing data were extracted from existing datasets. A 2016 mixed-mode mail and telephone survey collected patient-reported data, including the main patient-reported outcomes of pain-related function (Brief Pain Inventory interference; BPI-I scores 0-10, higher scores = worse) and health-related quality of life. Data on survey participants and non-participants were analyzed to assess potential nonresponse bias. Weights were used to account for design. Linear regression models were used to assess cross-sectional associations of opioid treatment with patient-reported measures. Of 14,160 patients contacted, 9253 (65.4%) completed the survey. Participants were older than non-participants (63.9 ± 10.6 vs. 59.6 ± 13.0 years). The mean number of bothersome pain locations was 6.8 (SE 0.04). Effectiveness of pain treatment and quality of pain care were rated fair or poor by 56.1% and 45.3%, respectively. The opioid daily dosage range was 1.6 to 1038.2 mg, with mean = 50.6 mg (SE 1.1) and median = 30.9 mg (IQR 40.7). Among the 73.2% of patients who did not receive long-acting opioids, the mean daily dosage was 30.4 mg (SE 0.6) and mean BPI-I was 6.4 (SE 00.4). Among patients who received long-acting opioids, the mean daily dosage was 106.2 mg
“…[ [37][38][39][40] The major strengths of this study include the large national sample, good survey response rate, and linkage to high-quality EMR and pharmacy dispensing data. This study also has limitations.…”
In the United States (US), long-term opioid therapy has been commonly prescribed for chronic pain. Since recognition of the opioid overdose epidemic, clinical practice guidelines have recommended tapering long-term opioids to reduced doses or discontinuation. The Effects of Prescription Opioid Changes for veterans (EPOCH) study is a national population-based prospective observational study of US Veterans Health Administration primary care patients designed to assess effects of evolving opioid prescribing practice on patients treated with long-term opioids for chronic pain. A stratified random sampling design was used to identify a survey sample from the target population of patients treated with opioid analgesics for � 6 months. Demographic, diagnostic, visit, and pharmacy dispensing data were extracted from existing datasets. A 2016 mixed-mode mail and telephone survey collected patient-reported data, including the main patient-reported outcomes of pain-related function (Brief Pain Inventory interference; BPI-I scores 0-10, higher scores = worse) and health-related quality of life. Data on survey participants and non-participants were analyzed to assess potential nonresponse bias. Weights were used to account for design. Linear regression models were used to assess cross-sectional associations of opioid treatment with patient-reported measures. Of 14,160 patients contacted, 9253 (65.4%) completed the survey. Participants were older than non-participants (63.9 ± 10.6 vs. 59.6 ± 13.0 years). The mean number of bothersome pain locations was 6.8 (SE 0.04). Effectiveness of pain treatment and quality of pain care were rated fair or poor by 56.1% and 45.3%, respectively. The opioid daily dosage range was 1.6 to 1038.2 mg, with mean = 50.6 mg (SE 1.1) and median = 30.9 mg (IQR 40.7). Among the 73.2% of patients who did not receive long-acting opioids, the mean daily dosage was 30.4 mg (SE 0.6) and mean BPI-I was 6.4 (SE 00.4). Among patients who received long-acting opioids, the mean daily dosage was 106.2 mg
“…Patients may be unaware of alternatives such as non-opioid pain relief and lifestyle approaches such as yoga that may be just as effective. [11,12] Given the importance of discussing harms versus benefits of opioids, and the need to discuss non-opioid treatment alternatives with patients, communication is a central aspect of chronic pain management and possibly addiction risk reduction. [13] Studies have sought to gain a greater understanding of communication about pain and opioids, [14][15][16] Toward this end, we sought to examine primary care provider (PCP) and patient characteristics associated with discussions of pain and opioid management.…”
Highlights (no more than 85 characters including spaces per bullet) Chronic non-cancer pain is common with over 100 million people affected. There is little evidence that opioids are effective for long-term pain management. Opioid prescribing for chronic pain is under increased scrutiny in the U.S. Patient anxiety, catastrophizing, and alliance are associated with opioid talk. Provider views on opioids, psychosocial role, and burnout linked with opioid talk.
“…So in my mind, when you're in serious pain, you need serious medication-which, serious medication is opioids." (29) "I definitely wanted the opiate [group] . .…”
Section: Patient Expectationsmentioning
confidence: 99%
“…I guess I was just thinking that it would be stronger medicine." (29) There were also several comments expressing concerns about the addictive potential of opioid pain medications.…”
Section: Patient Expectationsmentioning
confidence: 99%
“…You feel good." (29) "I had an opinion that I didn't want to end up on anything that could become addictive. Hydrocodone works.…”
Words can't express my gratitude for chairing my committee. Your guidance, mentorship and expertise took a small idea into meaningful research. Your approach to life inspires me. Dr. Leigh Speer-Thank you for giving me the chance to become an endodontist. I will never forget the call in which you offered me a spot in the program. I hope to make you proud. Dr. Keith Hildebrand-Thank you for all your support. Your pride in your state and West Virginia University is palpable. Thank you for sharing it with me for a short time. Dr. Bryan Weaver-Thank you for your input and support in serving on my committee. Your leadership in the school of dentistry makes it a better place. Dr. Tom Borgia-Your work, support and guidance of the endodontics department and West Virginia School of Dentistry over the years is immeasurable. Thank you. Dr. Mark Byron-Thank you for answering the call to lead the program. I have learned much from you and am a better clinician for it. Dr. Sam Dorn-Your contributions to the field of endodontics is inspirational. I am privileged to get to learn from you over these last few months. Dr. Mehran Malakpour-You and I hit it off from day one at the interview. There is no better co-resident I could have asked for. The things you have achieved this far in your life are beyond impressive. I am proud to call you my colleague and friend. Mr. Jonathan Gore-You help with data collection and entry was absolutely invaluable. Your hard work and attention to detail will serve you well and you have a great future ahead of you.
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