I want to lie about not knowing you, but my precuneus refuses to cooperate

Lee, Tatia M.C.; Leung, Michael K. H.; Lee, Tiffany M. Y.; Raine, Adrian; Chan, Che Hin Chetwyn

doi:10.1038/srep01636

Cited by 30 publications

(26 citation statements)

References 46 publications

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“…Precuneus activity has been reported in fMRI studies of face processing (metaanalysis in Fusar-Poli et al, 2009), and has specifically been associated with social recognition (Lee et al, 2013). In general, the precuneus is thought to play a role in self-awareness and higher cognitive processes above and beyond sensory discrimination (reviewed in Cavanna and Trimble, 2006).…”

Section: Discussionmentioning

confidence: 99%

A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: an fMRI study

Lee

Coccaro

Cremers

et al. 2013

Front. Syst. Neurosci.

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Background: We hypothesized that SRX246, a vasopressin V1a receptor antagonist, blocks the effect of intranasally administered vasopressin on brain processing of angry Ekman faces. An interaction of intranasal and oral drug was predicted in the amygdala.Methods: Twenty-nine healthy male subjects received a baseline fMRI scan while they viewed angry faces and then were randomized to receive oral SRX246 (120 mg PO twice a day) or placebo. After an average of 7 days of treatment, they were given an acute dose of intranasal vasopressin (40 IU) or placebo and underwent a second scan. The primary outcome was BOLD activity in the amygdala in response to angry faces. Secondary analyses were focused on ROIs in a brain regions previously linked to vasopressin signaling.Results: In subjects randomized to oral placebo-intranasal vasopressin, there was a significantly diminished amygdala BOLD response from the baseline to post-drug scan compared with oral placebo-intranasal placebo subjects. RM-ANOVA of the BOLD signal changes in the amygdala revealed a significant oral drug × intranasal drug × session interaction (F(1, 25) = 4.353, p < 0.05). Follow-up tests showed that antagonism of AVPR1a with SRX246 blocked the effect of intranasal vasopressin on the neural response to angry faces. Secondary analyses revealed that SRX246 treatment was associated with significantly attenuated BOLD responses to angry faces in the right temporoparietal junction, precuneus, anterior cingulate, and putamen. Exploratory analyses revealed that the interactive and main effects of intranasal vasopressin and SRX246 were not seen for happy or neutral faces, but were detected for aversive faces (fear + anger) and at a trend level for fear faces.Conclusion: We found confirmatory evidence that SRX246 has effects on the amygdala that counter the effects of intranasal vasopressin. These effects were strongest for angry faces, but may generalize to other emotions with an aversive quality.

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Section: Discussionmentioning

confidence: 99%

A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: an fMRI study

Lee

Coccaro

Cremers

et al. 2013

Front. Syst. Neurosci.

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“…Research on the precuneus has accelerated in the past decade due to development of non-invasive medical imaging techniques, namely MRI, fMRI, and PET. Functional studies have revealed that the precuneus is involved in a variety of functions associated with self-perception and visual imagery [Lou et al, 2004; Land, 2014], processing of spatial working memory [Wallentin et al, 2006, 2008], and memory retrieval (recognition of familiar faces [Gobbini and Haxby, 2007; Lee et al, 2013]; episodic memory [Vannini et al, 2011]; recognition memory [Hassabis and Maguire, 2009] autobiographical memory [Freton et al, 2014]). Moreover, the precuneus is a functional core of the Default Mode Network, a set of interconnected cortical areas that is active at rest [Raichle et al, 2001; Tomasi and Volkow, 2010; Utevsky et al, 2014], and it is a crucial hub of large-scale brain connectivity [Hagmann et al, 2008; Li et al, 2013; Reus et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Midsagittal Brain Variation among Non-Human Primates: Insights into Evolutionary Expansion of the Human Precuneus

Pereira‐Pedro

Rilling²,

Chen

et al. 2017

Brain Behav Evol

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The precuneus is a major element of the superior parietal lobule, positioned on the medial side of the hemisphere and reaching the dorsal surface of the brain. It is a crucial functional region for visuospatial integration, visual imagery, and body coordination. Previously, we argued that the precuneus expanded in recent human evolution, based on a combination of paleontological, comparative, and intraspecific evidence from fossil and modern human endocasts as well as from human and chimpanzee brains. The longitudinal proportions of this region are a major source of anatomical variation among adult humans and, being much larger in Homo sapiens, is the main characteristic differentiating human midsagittal brain morphology from that of our closest living primate relative, the chimpanzee. In the current shape analysis, we examine precuneus variation in non-human primates through landmark-based models, to evaluate the general pattern of variability in non-human primates, and to test whether precuneus proportions are influenced by allometric effects of brain size. Results show that precuneus proportions do not covary with brain size, and that the main difference between monkeys and apes involves a vertical expansion of the frontal and occipital regions in apes. Such differences might reflect differences in brain proportions or differences in cranial architecture. In this sample, precuneus variation is apparently not influenced by phylogenetic or allometric factors, but does vary consistently within species, at least in chimpanzees and macaques. This result further supports the hypothesis that precuneus expansion in modern humans is not merely a consequence of increasing brain size or of allometric scaling, but rather represents a species-specific morphological change in our lineage.

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“…To provide a better marker of deception that differs from executive functions, Lee et al (2013) focused on perceptual functions. During a Face Recognition task, participants were instructed to lie about the familiarity of a set of photos: the faces of individuals who were personally familiar to the participants and the faces of unfamiliar persons.…”

Section: Other Correlates Of Deceptionmentioning

confidence: 99%

The guilty brain: the utility of neuroimaging and neurostimulation studies in forensic field

Mameli

Scarpazza

Tomasini

et al. 2017

Reviews in the Neurosciences

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AbstractSeveral studies have aimed to address the natural inability of humankind to detect deception and accurately discriminate lying from truth in the legal context. To date, it has been well established that telling a lie is a complex mental activity. During deception, many functions of higher cognition are involved: the decision to lie, withholding the truth, fabricating the lie, monitoring whether the receiver believes the lie, and, if necessary, adjusting the fabricated story and maintaining a consistent lie. In the previous 15 years, increasing interest in the neuroscience of deception has resulted in new possibilities to investigate and interfere with the ability to lie directly from the brain. Cognitive psychology, as well as neuroimaging and neurostimulation studies, are increasing the possibility that neuroscience will be useful for lie detection. This paper discusses the scientific validity of the literature on neuroimaging and neurostimulation regarding lie detection to understand whether scientific findings in this field have a role in the forensic setting. We considered how lie detection technology may contribute to addressing the detection of deception in the courtroom and discussed the conditions and limits in which these techniques reliably distinguish whether an individual is lying.

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I want to lie about not knowing you, but my precuneus refuses to cooperate

Cited by 30 publications

References 46 publications

A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: an fMRI study

A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: an fMRI study

Midsagittal Brain Variation among Non-Human Primates: Insights into Evolutionary Expansion of the Human Precuneus

The guilty brain: the utility of neuroimaging and neurostimulation studies in forensic field

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