vic‐Tricarbonyl Compounds of Quinolines: Analogues of Ninhydrin: A Short Review

Abstract

in Wiley Online Library (wileyonlinelibrary.com).Derivatives of ninhydrin are extensively used in the field of forensic sciences as important latent fingerprint reagents. Many works have been performed upon their synthesis and reactivity, but there are many spaces to work on the compounds of quinoline-2,3,4(1H)-triones-analogues of ninhydrin, in both dimensions: synthesis and reactivity, and according to the best of our knowledge, not a single detailed or short compiled article has been published for these compounds. This review briefly summarizes the chemistry of quinoline-2,3,4(1H)-triones.Scheme 4. Photochemical approach to synthesize quinoline-2,3,4(1H)triones (4) with singlet oxygen. MB, methylene blue; RB, rose bengal.Scheme 5. Thermal approach to synthesize quinoline-2,3,4(1H)-triones (4) form 4-hydroxyquinolin-2(1H)-ones (5) using phenyliodine(III) diacetate as oxidizing agent. Scheme 6. Reactions of quinoline-2,3,4(1H)-triones (4) with diazoalkanes. THF, tetrahydrofuran.

Ninhydrin Adducts as Valid Synthon in Organic Synthesis: A Review

“…The design and synthesis of diverse molecular entities utilizing vicinal tricarbonyl compounds have become an active area of organic chemistry research . Among various tricarbonyls, ninhydrin (1,2,3‐indanetrione hydrate) occupies an important position in the chemical landscape due to its low‐cost, easy availability and high reactivity.…”