<i>Viburnum opulus</i> fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model

Bidian, Cristina; Filip, Gabriela Adriana; David, Luminiţa; Moldovan, Bianca; Bâldea, Ioana; Olteanu, Diana; Filip, Mara; Bolfă, Pompei; Potara, Monica; Toader, Alina; Clichici, Simona

doi:10.1080/17518253.2022.2061872

Cited by 7 publications

(6 citation statements)

References 68 publications

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“…Metal nanoparticles possess unique optical properties due to the resonance of the surface plasmon (SPR). In the case of gold nanoparticles, the excitation of SPR in colloidal solution is responsible for producing absorption maxima situated at wavelength values in the range of 500–550 nm [ 26 ]. Figure 1 displays the UV-vis spectra of goji fruit extract and green synthesized AuNPs, depicting the presence of the characteristic gold SPR band at 536 nm.…”

Section: Resultsmentioning

confidence: 99%

Goji-Berry-Mediated Green Synthesis of Gold Nanoparticles and Their Promising Effect on Reducing Oxidative Stress and Inflammation in Experimental Hyperglycemia

David,

Morosan,

Moldovan

et al. 2023

Antioxidants

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The present report focuses on a rapid and convenient method applicable in the green synthesis of gold nanoparticles (AuNPs) using goji berry (Lycium barbarum—LB) extracts rich in antioxidant compounds, as well as on the structural analysis and evaluation of the induced antioxidant protection and anti-inflammatory effects of the synthesized gold nanoparticles upon endothelial cells (HUVECs) exposed to hyperglycemia. The synthesized AuNPs were characterized using ultraviolet–visible (UV-Vis) spectroscopy and transmission electron microscopy (TEM), whereas the presence of bioactive compounds from the L. barbarum fruit extract on the surface of the nanoparticles was confirmed using Fourier transform infrared spectroscopy (FTIR). The antioxidant activity of the biosynthesized gold nanoparticles was evaluated on the HUVEC cell line. The results reveal that AuNPs with a predominantly spherical shape and an average size of 30 nm were obtained. The UV-Vis spectrum showed a characteristic absorption band at λmax = 536 nm of AuNPs. FTIR analysis revealed the presence of phenolic acids, flavonoids and carotenoids acting as capping and stabilizing agents of AuNPs. Both the L. barbarum extract and AuNPs were well tolerated by HUVECs, increased the antioxidant defense and decreased the production of inflammatory cytokines induced via hyperglycemia-mediated oxidative damage.

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Section: Resultsmentioning

confidence: 99%

Goji-Berry-Mediated Green Synthesis of Gold Nanoparticles and Their Promising Effect on Reducing Oxidative Stress and Inflammation in Experimental Hyperglycemia

David,

Morosan,

Moldovan

et al. 2023

Antioxidants

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“…Group III served as the test group and received ZnO NPs (36.5 mg/kg) and 0.1 mL of carrageenan. The volume displacement (VD) of mercury in mL was measured using a mercury plethysmometer at 0, 1, and 2 h of drug administration. , The percent inhibition of edema was calculated as in eq : normalPercentage 0.25em of 0.25em normalinhibition 0.25em % = false( VD in untreated group − VD in treated group false) false( VD in untreated group false) × 100 …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antioxidant and Anti-inflammatory Applications of Aerva persica Aqueous-Root Extract-Mediated Synthesis of ZnO Nanoparticles

Fatima,

Asif,

Farooq

et al. 2024

ACS Omega

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In the present study, ZnO nanoparticles were synthesized by using aqueous extracts of Aerva persica roots. Characterization of as-prepared ZnO nanoparticles was carried out using different techniques, including powder X-ray diffraction (XRD), UV−vis diffuse reflectance spectroscopy (DRS), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and BET surface area analysis. Morphological analysis confirmed the small, aggregated flake-shaped morphology of as-synthesized ZnO nanostructures. The as-prepared ZnO nanoparticles were analyzed for their potential application as antiinflammatory (using in vivo inhibition of carrageenan induced paw edema) and antioxidant (using in vitro radical scavenging activity) agents. The ZnO nanoparticles were found to have a potent antioxidant and anti-inflammatory activity comparable to that of standard ascorbic acid (antioxidant) and indomethacin (anti-inflammatory drug). Therefore, due to their ecofriendly synthesis, nontoxicity, and biocompatible nature, zinc oxide nanoparticles synthesized successfully from roots extract of the plant Aerva persica with potent efficiencies can be utilized for different biomedical applications.

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“…During the late phase, which occurs 2-30 min to 6 h after Carrageenan injection, macrophages and neutrophils produce free radicals, secrete cytokines (including IL-1, IL-6, TNF-and IL-10), infiltrate the area, activate cyclooxygenase (COX-2), synthesise nitric oxide, and eventually produce prostaglandins. 56,57 The findings showed that C. nepeta EO has a strong anti-inflammatory effect against Carrageenan-induced paw edema at a dose of 400 mg/kg when compared to Diclofenac and other doses (100 and 200 mg/kg). This herb was previously used as an anti-inflammatory and analgesic treatment against febrile colds and respiratory disorders.…”

Section: Carrageenan-induced Paw Size Edemamentioning

confidence: 98%

Chemical Composition and Pharmacological Activities of Calamintha nepeta Essential Oil

2024

TJNPR

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Calamintha nepeta (Lamiaceae), widely distributed throughout the Mediterranean area, is a small and fragrant perennial herb traditionally used for both culinary and medicinal purposes. It serves as an antiseptic, spasmolytic, diuretic, and cough suppressant. The objective of this research is to characterise the chemical constituents of Calamintha nepeta essential oil (EO) through GC-MS analysis and evaluate its antioxidant and antimicrobial properties against nine multidrug resistant bacterial strains and one yeast. The study also conducted an in vitro anti-inflammatory 5lipoxygenase inhibition test and determined its lethal dose 50 (LD50) as well as the effects against carrageenan-induced paw edema in vivo. Analysis revealed that the primary components of C. nepeta included oxygenated monoterpenes, notably pulegone (58.36%), isoborneol (10.40%), menthone (8.91%), and piperitenone (3.86%). Antimicrobial tests demonstrated significant inhibition zones ranging from 10.2 to 37.12 mm. Essential oil exhibited minimum inhibitory concentrations and bactericidal/fungicidal concentrations ranging from 0.937 to 3.75 µL/mL and 0.937 to 15 µL/mL, respectively. Furthermore, it showed potent antioxidant activity against DPPH and a high total reducing power. Acute oral toxicity tests in Wistar rats indicated an LD50 of 2500 mg/kg. C. nepeta EO also exhibited strong anti-inflammatory properties against carrageenaninduced paw edema, with an IC50 value of 17.23 ± 0.32 μg/mL compared to diclofinac. Interestingly, this research highlights the importance of the phytochemical and antimicrobial properties of the essential oil of the Calamintha nepeta and accentuats its importance in pharmacological applications for treating inflammatory conditions.

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Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model

Cited by 7 publications

References 68 publications

Goji-Berry-Mediated Green Synthesis of Gold Nanoparticles and Their Promising Effect on Reducing Oxidative Stress and Inflammation in Experimental Hyperglycemia

Goji-Berry-Mediated Green Synthesis of Gold Nanoparticles and Their Promising Effect on Reducing Oxidative Stress and Inflammation in Experimental Hyperglycemia

Antioxidant and Anti-inflammatory Applications of Aerva persica Aqueous-Root Extract-Mediated Synthesis of ZnO Nanoparticles

Chemical Composition and Pharmacological Activities of Calamintha nepeta Essential Oil

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