<i>Vibrio vulnificus</i>Septicemia: Report of Four Cases

Kim, Jin Ju; Yoon, Kap Joon; Yoon, Hong Sup; Chong, Yunsop; Lee, Samuel Y.; Chon, Chae Yoon; Park, In Suh

doi:10.3349/ymj.1986.27.4.307

Cited by 5 publications

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“…The usual sites of skin manifestations are one or both lower extremities and the trunk. 5,11,68,94 In contrast to wound infection, cutaneous lesions associated with primary septicemia occur less frequently on the arms and especially the hands. To the best of our knowledge, all case reports of upper extremity involvement have been characterized by either diffuse distribution involving bilateral upper and lower extremities or a single limb.…”

Section: Final Comments About the Illustrative Casementioning

confidence: 99%

A comprehensive review of Vibrio vulnificus: an important cause of severe sepsis and skin and soft-tissue infection

Horseman

Surani

2011

International Journal of Infectious Diseases

261

303

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Vibrio vulnificus is a halophilic Gram-negative bacillus found worldwide in warm coastal waters. The pathogen has the ability to cause primary sepsis in certain high-risk populations, including patients with chronic liver disease, immunodeficiency, iron storage disorders, end-stage renal disease, and diabetes mellitus. Most reported cases of primary sepsis in the USA are associated with the ingestion of raw or undercooked oysters harvested from the Gulf Coast. The mortality rate for patients with severe sepsis is high, exceeding 50% in most reported series. Other clinical presentations include wound infection and gastroenteritis. Mild to moderate wound infection and gastroenteritis may occur in patients without obvious risk factors. Severe wound infection is often characterized by necrotizing skin and soft-tissue infection, including fasciitis and gangrene. V. vulnificus possesses several virulence factors, including the ability to evade destruction by stomach acid, capsular polysaccharide, lipopolysaccharide, cytotoxins, pili, and flagellum. The preferred antimicrobial therapy is doxycycline in combination with ceftazidime and surgery for necrotizing soft-tissue infection.

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Section: Final Comments About the Illustrative Casementioning

confidence: 99%

A comprehensive review of Vibrio vulnificus: an important cause of severe sepsis and skin and soft-tissue infection

Horseman

Surani

2011

International Journal of Infectious Diseases

261

303

View full text Add to dashboard Cite

show abstract

“…According to the literature, there have been 60 reported cases of V. vulnificus infection (49 cases of the primary septicaemia type and 11 of the wound infection type) between January 1981 and June 1999 5,9–16 . Thirty‐one (63%) of 49 patients with the primary septicaemia type died, whereas only one (9%) of 11 patients with the wound infection type died.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining patient had arm involvement, and survived. When we analysed the anatomical sites of initial skin lesions in the 60 reported cases, 5,9–16 33 of 49 patients with primary septicaemia (67%) were initially affected on the legs, and of these 24 (73%) died. Seven of the 49 patients (14%) had initial skin lesions on the arms and three of them (43%) died.…”

Section: Discussionmentioning

confidence: 99%

“…Data on CPK levels were available in only nine patients from 60 case reports 5,9–16 . In all cases, CPK levels were elevated, and seven patients (78%) died.…”

Section: Discussionmentioning

confidence: 99%

“…However, the relationship between prognosis and WCC in patients with V. vulnificus infection seems to be unclear from the analyses in the literature. Of the 60 case reports, 5,9–16 51 gave the WCC: 42 patients had the primary septicaemia type and nine the wound infection type. In the 42 patients with the primary septicaemia type, nine of 12 (75%) with WCC < 4 × 10 9 L −1 and 17 of 30 (57%) with WCC > 4 × 10 9 L −1 died.…”

Section: Discussionmentioning

confidence: 99%

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