Vaccinium myrtillus L. extract associated with octocrylene, bisoctrizole, and titanium dioxide: in vitro and in vivo tests to evaluate safety and efficacy

Ruscinc, Nádia; Morocho‐Jácome, Ana Lucía; Martinez, Renata Miliani; Magalhães, Wagner Vidal; Escudeiro, Cassiano Carlos; Giarolla, Jeanine; Rosado, Catarina; Velasco, Maria Valéria Robles; Baby, André Rolim

doi:10.1111/jocd.14779

Cited by 7 publications

(3 citation statements)

References 67 publications

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“…We noticed that samples containing RA, independently of the presence of UV filters, were not able to maintain the cutaneous superficial hydration effect on the 7 th day, however, all samples positively interacted with this skin attribute after 30 minutes. Tomazelli and coworkers, and Ruscinc and coworkers observed compatible results from their multifunction bioactive sunscreens containing 0.1% rutin and 5.0% Vaccinium myrtillus L. extract, respectively, when in vivo skin hydration was not improved after application of those products [30,31].…”

Section: Discussionmentioning

confidence: 77%

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Cândido¹,

Ariede²,

Pinto³

et al. 2022

Preprint

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The skin acts as a protective barrier, guarding the body against microorganisms, chemicals, and several environmental factors. Accordingly, this all-important organ must be kept healthy to maintain its optimal functionality. One approach to maintain skin health is the application of multifunction bioactive sunscreens containing antioxidant molecule(s). Rosmarinic acid (RA), a phenolic compound, is known for its antioxidant activity. Herein, the safety and efficacy of a multifunction prototype sunscreen were investigated, aiming to probe putative synergies of this polyphenol with two known and widely used UV filters (bemotrizinol and octyl p-methoxycinnamate). Samples protected the DNA fragmentation compared to UV control, by the comet assay, and showed good skin compatibility in subjects. Formulations F1 and F3 were able to increase skin hydration, and, possibly, the RA interfered with this attribute. An increase in transepidermal water loss was observed for formulations F1, F2 and F4, which may be related to vehicle containing or not the RA. No decreases were observed in the inflammatory reaction caused by the ethyl nicotinate with any of the evaluated formulations. As a perspective, we suggest trials with a greater number of subjects or protocol modifications. Altering the vehicle qualitative and quantitative composition is also a pertinent perspective.

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Section: Discussionmentioning

confidence: 77%

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Cândido¹,

Ariede²,

Pinto³

et al. 2022

Preprint

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“…However, in another very recent study, the bilberry fruit extract was found to reduce the sun protection factor upon incorporation into the tested sunscreens. This is a very unexpected and paradoxical result which requires further scientific attention ( Ruscinc et al, 2022 ).…”

Section: Uses Of Vaccinium Myrtillus Lmentioning

confidence: 99%

Bilberries: Curative and Miraculous – A Review on Bioactive Constituents and Clinical Research

Vaneková

Rollinger

2022

Front. Pharmacol.

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Bilberry (Vaccinium myrtillus L.) fruits are an important part of local diets in many countries and are used as a medicinal herb to treat various disorders. Extracts from fruits are often a part of eye health-promoting supplements, whereas extracts from leaves are advertised for type 2 diabetes mellitus and glycemic control. This review provides an overview of the current knowledge of the phytochemical contents of bilberry fruits and leaves and their bioactivities, critically summarizes origins of the health claims and the outcome of clinical trials, with special attention towards those published in the past 10 years. Overall, the three most referenced indications, which are type 2 diabetes mellitus, vision disorders and circulatory diseases, all include contradictory results with no clear conclusion as to the benefits and recommended dosages. Moreover, the indications for vision disorders and diabetes originate from unproven or false claims that have been repeated in research since the 20th century without consistent fact-checking. Beneficial clinical results have been attested for the treatment of dyslipidemia and chronic inflammatory disorders when applied as dietary supplementation of fresh bilberries or as anthocyanin-rich bilberry fruit extracts. However, there is a general lack of double-blinded controlled research with larger sample sizes.

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“…The in vitro photoprotective efficacy of the formulations was determined by a Labsphere ® UV2000S. Aliquots of the samples were weighed and uniformly applied, respecting the application rate of 1.3 mg/cm 2 , on the surface of polymethyl methacrylate (PMMA) plates [16][17][18]. After drying for 30 min protected from the light, the plates were subjected to the reflectance spectrophotometric reading and at least five transmittance readings per plate were registered.…”

Section: Photoprotective Efficacy and Photostability Of Formulationsmentioning

confidence: 99%

Prospecting In Vitro Antioxidant and Photoprotective Properties of Rosmarinic Acid in a Sunscreen System Developed by QbD Containing Octyl p-Methoxycinnamate and Bemotrizinol

et al. 2022

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Progressively growing diagnoses of skin cancer trigger public health concerns about excessive sun exposure, awareness of the deleterious effects of ultraviolet (UV) radiation on the skin, and the proper use of sunscreens. Studies show that bioactive molecules, such as rosmarinic acid (RA), may potentiate the photoprotective and antioxidant activity of topical formulations. This research presents the application of the concepts of quality by design (QbD) to evaluate the critical parameters of quality and the development of an optimized cosmetic formulation with RA by means of an understanding of product design space. Samples were developed using design of experiments (DoE) and they were evaluated for in vitro antioxidant activity and photoprotective efficacy, as well as for photostability through artificial irradiation. We were able to achieve the RA performance regarding antioxidant and SPF properties through in vitro experiments. We obtained the equations for predicting the in vitro antioxidant activity and SPF. Considering our sunscreen system, developed with octyl p-methoxycinnamate and bemotrizinol, the presence of RA increased its antioxidant capacity; however, the in vitro SPF was reduced when both UV filters were used. The development of multifunctional sunscreens is of utmost importance; moreover, there is a need for the rational development of formulations that ensure representative statistical tests of the effects and interactions among the components of a formulation on the desired critical quality attributes, including efficacy.

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Vaccinium myrtillus L. extract associated with octocrylene, bisoctrizole, and titanium dioxide: in vitro and in vivo tests to evaluate safety and efficacy

Cited by 7 publications

References 67 publications

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Bilberries: Curative and Miraculous – A Review on Bioactive Constituents and Clinical Research

Prospecting In Vitro Antioxidant and Photoprotective Properties of Rosmarinic Acid in a Sunscreen System Developed by QbD Containing Octyl p-Methoxycinnamate and Bemotrizinol

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