<i>Ureaplasma urealyticum</i> cervical colonization as a marker for pregnancy complications

Horowitz, Shulamith; Horowitz, J; Mazor, Moshe; Porath, Avi; Glezerman, Marek

doi:10.1016/0020-7292(94)02236-4

Cited by 19 publications

(15 citation statements)

References 22 publications

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“…Similarly, it was concluded by Wenstrom et al (4) that high levels of IL-6 at genetic amniocentesis can predict subsequent pregnancy loss. The association of Ureaplasma urealyticum with pregnancy complications was previously reported by several groups including ours (6)(7)(8)17). Moreover, Horowitz et al (18) previously showed that the three women with U.urealyticum infection also had high titers of anti-ureaplasma antibodies.…”

Section: Discussionsupporting

confidence: 68%

Elevated concentrations of interleukin‐6 in intra‐amniotic infection with Ureaplasma urealyticum in asymptomatic women during

Bashiri

Horowitz

Huleihel

et al. 1999

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 68%

Elevated concentrations of interleukin‐6 in intra‐amniotic infection with Ureaplasma urealyticum in asymptomatic women during

Bashiri

Horowitz

Huleihel

et al. 1999

Acta Obstet Gynecol Scand

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“…Conflicting associations between mollicutes and preterm birth have had a long history, not only related to population tested, but also to testing itself (culture vs PCR) (5,7,8,9,10,11,12,16,20,21,22,23,24,25,26). We used PCR probes that can separate M hominis , M genitalium , and U parvum from U urealyticum (18).…”

Section: Discussionmentioning

confidence: 99%

“…Some urogenital mollicutes ( Mycoplasma and Ureaplasma species, which are bacteria without cell walls) have been associated by culture with preterm birth in many (7,8,9,10), but not all (5,11,12), studies. Causality for preterm birth or labor is plausible because mollicutes possess adhesion molecules that interact with toll-like receptors and stimulate secretion of pro-inflammatory cytokines IL2, IL4, and IL6 (2,4,5,6,12,13,14).…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic Factors and Urogenital Infections Associated With Preterm Birth in a Midwestern U.S. Population

Agger

Siddiqui

Lovrich

et al. 2014

Obstetrics &Amp; Gynecology

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Objective To correlate epidemiologic factors with urogenital infections associated with preterm birth. Methods Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for potential pathogens. Results Six hundred seventy-six women were evaluated. Fifty-four (8.0%) had preterm birth: 12.1% (19/157) large urban, 8.8% (15/170) midsize urban, 9.4% (16/171) small city, and 2.3% (4/178) rural city. Associated host factors and infections varied significantly among sites. Urogenital infection rates, especially Mycoplasma hominis and Ureaplasma parvum, were highest at the large urban site. Large urban site, minority ethnicity, multiple infections, and certain historical factors were associated with preterm birth by univariable analysis. By multivariable analysis, preterm birth was associated with prior preterm birth (adjusted odds ratio [aOR] 2.76, 95% confidence interval [CI] 1.27–6.02) and urinary tract infection (aOR 2.62, 95% CI 1.32–519), and negatively associated with provider-assessed good health (aOR 0.42, 95% CI 0.23–0.76) and group B streptococcal infection treatment (surrogate for healthcare utilization) (aOR 0.38, 95% CI 0.15–.99). Risk and protective factors were similar for women with birth at < 35 weeks, and additionally associated with M hominis (aOR 3.6, 95% CI 1.4–9.7). Conclusion These measured differences between sites are consistent with observations that link epidemiologic factors, both environmental and genetic, with minimally pathogenic vaginal bacteria, inducing preterm birth, especially at less than 35 weeks of gestation.

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“…can be isolated from endometrial tissue of healthy, nonpregnant women, indicating that they may be present at the time of implantation and might therefore be involved in early pregnancy losses (44). Horowitz et al (122) reported that women whose cervices were culture positive for Ureaplasma spp. and who had a high level of antibody against ureaplasmas were more likely to develop pregnancy complications than women with a negative culture and absence of antibodies.…”

Section: Chorioamnionitis Spontaneous Abortion and Preterm Labormentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Ureaplasma urealyticum cervical colonization as a marker for pregnancy complications

Abstract: Cervical colonization with Uu when associated with elevated titers of antibodies to Uu, may serve as a marker for the identification of a subpopulation of women who are at high risk for the development of pregnancy complications.

Cited by 19 publications

References 22 publications

Elevated concentrations of interleukin‐6 in intra‐amniotic infection with Ureaplasma urealyticum in asymptomatic women during

Elevated concentrations of interleukin‐6 in intra‐amniotic infection with Ureaplasma urealyticum in asymptomatic women during

Epidemiologic Factors and Urogenital Infections Associated With Preterm Birth in a Midwestern U.S. Population

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

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