TSC22D,WNKandNRBPgene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing
Yu-Xi Xiao,
Seon Yong Lee,
Magali Aguilera-Uribe
et al.
Abstract:The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. Myriad redundancies have evolved across all facets of osmosensing in metazoans, including among water and ion transporters, regulators of cellular morphology, and macromolecular crowding sensors, hampering efforts to gain a clear understanding of how cells respond to rapid water loss. In this study, we harness the power of gene co-essentiality analysis and genome-scale CRISPR-Cas9 screening to identi… Show more
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