<i>Trypanosoma cruzi</i> infection in mice enhances the membrane expression of low‐affinity Fc receptors for IgG and the release of their soluble forms

Araujo-Jorge, Tania C.; Bouhdidi, A el; Rivera, M. T.; Daëron, Marc; Carlier, Yves

doi:10.1111/j.1365-3024.1994.tb00298.x

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…1b). In addition, the killing of Fc␥R ϩ A20 targets by Jo2 was inhibited by 2.4G2 mAb that blocks Fc binding to Fc␥RII and Fc␥RIII (17,18). The control rat IgG2b did not inhibit the killing (Fig.…”

Section: Fc␥r Expression On Target Cellsmentioning

confidence: 92%

“…The Target Cells of Jo2 Responsible for Lethality Are Radioresistant-In the hematopoietic system, Fc␥RII is abundantly expressed on macrophages, B cells, neutrophils, eosinophils, and platelets (10,17,18). In the liver, Fc␥RII is found on the sinusoidal lining cells but not on hepatocytes, and Fc␥RIII expression on the sinusoidal lining cells is controversial (11,12).…”

Section: Fc␥r Expression On Target Cellsmentioning

confidence: 99%

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Anti-CD95-induced Lethality Requires Radioresistant FcγRII+ Cells

Jodo

Kung

Xiao

et al. 2003

Journal of Biological Chemistry

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Section: Fc␥r Expression On Target Cellsmentioning

confidence: 92%

Section: Fc␥r Expression On Target Cellsmentioning

confidence: 99%

Anti-CD95-induced Lethality Requires Radioresistant FcγRII+ Cells

Jodo

Kung

Xiao

et al. 2003

Journal of Biological Chemistry

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“…1996). They are also found in the host's circulation (Ulvestad, Matre & Tonder 1988, Araujo Jorge et al . 1993).…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of a Fc Receptor activity on the Toxoplasma gondii tachyzoite

Vercammen¹,

Bouhdidi

Messaoud

et al. 1998

Parasite Immunology

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The Immunoglobulin (Ig) binding capacity of Toxoplasma gondii tachyzoites was investigated using fluorescence flow-cytometry analysis. Polyclonal mouse, human and rat immunoglobulins without specific anti-Toxoplasma activity bound to parasites in a concentration-dependent manner, saturating them at circulating serum concentrations. The immunoglobulin class and subclass specificity of binding was investigated using irrelevant monoclonal antibodies. IgM, IgA and IgG reacted with the parasite membrane. The attachment of mouse IgM to the parasite surface was hampered by mouse IgG1, IgG2a, IgG2b and IgG3. The binding of mouse IgG was proportionally reduced with increasing concentrations of mouse monoclonal IgM. The binding of murine immunoglobulin was diminished when in presence of human IgG. Purified Fc- but not Fab portions of immunoglobulins, fixed to parasites. Using labelled calibrated beads, the Ig binding capacity of parasites was estimated to be 6900 +/- 500 sites per tachyzoite. The Kd of the T. gondii Fc Receptor (FcR) activity was determined at 1.4 +/- 0.1 microM (mean +/- SEM). Such FcR activity was reduced by phospholipase C, trypsin and pronase treatment of the parasites. These data show a low affinity FcR activity on T. gondii tachyzoites which recognizes Ig of different species and isotypes and is likely supported by a glycosyl-phosphatidylinositol (GPI)-anchored surface protein of the parasite.

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“…These macrophages have been used as a model system for studies of human macrophage function (34) because they express human Fc␥RIIA as well as endogenous mouse Fc␥RI, Fc␥RIIB, and Fc␥RIIIA. Importantly, mAb 2.4G2 can be used to block input from mouse Fc␥RIIB and Fc␥RIIIA (35), providing a method for distinguishing between the effect of human Fc␥RIIA and Fc␥RIIB in these macrophages.…”

Section: Modulation Of Cr3-mediated Phagocytosis By Fc␥rsmentioning

confidence: 99%