<i>Trypanosoma cruzi</i> in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmission

Leiby, David A.; Herron, Ross M.; Read, Elizabeth J.; Lenes, Bruce A.; Stumpf, Robert J.

doi:10.1046/j.1537-2995.2002.00077.x

Cited by 180 publications

(131 citation statements)

References 25 publications

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“…In the United States, seroprevalence rates among asymptomatic blood donors vary depending on the area, with an increased rate in areas where there is a significant number of immigrants from countries where the disease is endemic. A recent publication showed seroprevalence versus T. cruzi among blood donors to be 1:7,500 and 1:9,000 in Los Angeles and Miami, respectively (225).…”

Section: Diagnostic Methods (I) Parasitological Methodsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Diagnostic Methods (I) Parasitological Methodsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…For years, Chagas disease was considered one of the consequences of poor socioeconomic conditions in Latin America. While this statement is still true, Chagas disease transmission through blood transfusion and organ transplantation in nonendemic areas is currently recognized as a serious problem [7]. These data demonstrate that Chagas disease, although an old disease, is a contemporary concern and point to the importance of active epidemiological surveillance with efficient parasite-targeted veterinary care, dependable screening of human-derived blood and organs and reliable prophylaxis or therapeutic interventions.…”

Section: Human Chagas Disease: An Old Disease Many New Concernsmentioning

confidence: 96%

Current concepts in immunoregulation and pathology of human Chagas disease

Dutra¹,

Gollob

2008

Current Opinion in Infectious Diseases

113

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Purpose of review-Chagas disease is a complex ailment caused by infection with Trypanosoma cruzi. It afflicts millions in Latin America. Years of studies have focused on the development of pathology in Chagas disease and recent studies have helped us understand the cellular mechanisms behind differential clinical evolution of Chagas disease.Recent findings-We discuss recent findings concerning the cellular immune response in human Chagas disease focusing on immunoregulation and the development of pathology. We seek to put several findings into the context of a disease that initially controls an extreme and patent infection, and later progresses to a chronic phase marked by the presence (cardiac and digestive forms), or not (indeterminate form), of associated pathology.Summary-Several theories exist to explain differential clinical evolution of Chagas disease. A coherent understanding of these theories will certainly aid in determining what combination of them approximates the true development of chagasic pathology. For achieving the goal of developing a successful therapy or intervention, it is critical that no theory be excluded at this point, but. Rather, rather that a thoughtful analysis and assimilation of the best components of each system into a central theory that best fits the reality of human Chagas disease is desirable.

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“…Consequently, the oversight was attributed to mild symptoms and the physicians' lack of awareness with respect to Chagas disease transmission through blood transfusion (Kirchhoff et al, 2006). The blood supply in the United States is vulnerable to T. cruzi contamination due to an increasing Latin American population emigrating from countries where Chagas disease is endemic (Kirchhoff et al, 1987(Kirchhoff et al, , 2006Kirchhoff, 1993;Leiby et al, 2002;Beard et al, 2003), even though screening of blood for Chagas disease will begin soon in the United States (CDC, 2006;Lee, 2006).…”

Section: Chagas Disease Awareness In the United Statesmentioning

confidence: 99%

“…The triatomine's activity level is affected by temperature, and physicians are often the first to diagnose and respond to an emerging disease threat. Additionally, the literature indicates that cases beyond the six recorded so far are likely to have gone undiagnosed, indicating a need to evaluate physician awareness (Kirchhoff et al, 1987;Kirchhoff, 1993;Holbert et al, 1995;Leiby et al, 2000Leiby et al, , 2002Zayas et al, 2001;Kirchhoff et al, 2006;Dorn et al, 2007). Through the use of geographical information system (GIS) and survey analyses, this study examines the role that climate conditions (temperature) and disease awareness among physicians can play in the potential emergence of Chagas disease in the United States.…”

Section: Introductionmentioning

confidence: 99%

The potential for emergence of Chagas disease in the United States

et al. 2008

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Abstract. To determine the risk for Chagas disease (American trypanosomiasis) in the United States, the characteristics that make the triatomine vector effective and the areas most at risk for transmission were delineated. In addition, the status of Chagas disease awareness among physicians in areas with a potential risk for the disease was determined. A geographical information system (GIS) was used to analyze three triatomine species within the United States known to harbor Trypanosoma cruzi and that exhibit qualities of domesticity. An analysis of the minimum temperature threshold for increased triatomine activity delineates the current population at increased risk, and by incorporating temperature predictions for 2030, the population at risk under a future climate scenario was also delineated. Considering both environmental and social factors, a vignette-based physician survey, based on the results of the GIS analysis, was used to gauge the level of awareness of Chagas disease within the delineated higher risk range.

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Trypanosoma cruzi in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmission

Cited by 180 publications

References 25 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Current concepts in immunoregulation and pathology of human Chagas disease

The potential for emergence of Chagas disease in the United States

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