Trichinella spiralis Larval Extract as a Biological Anti‐Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma
Salwa S. Younis,
Amina M. Salama,
Dalia A. Elmehy
et al.
Abstract:Trichinella spiralis (T. spiralis) is an immunomodulating parasite that can adversely affect tumor growth and extend host lifespan. The aim of this study was to elucidate the mechanisms by which T. spiralis larval antigens achieve this effect using Ehrlich solid carcinoma (ESC) murine model. Assessment was done by histopathological and immunohistochemical analysis of caspase‐3, TNF‐α, Ki‐67 and CD31. Additionally, Bcl2 and Bcl2‐associated protein X (Bax) relative gene expression was assessed by molecular analy… Show more
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