trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder

Abstract

Background: trans-Resveratrol has been extensively investigated for its anti-inflammatory, antioxidant, and anti-psychiatric properties. However, whether it could rescue posttraumatic stress disorder-like stress-induced pain abnormality is unknown. Aim: The present study examined the effects of trans-resveratrol on anxiety-like behavior and neuropathic pain induced by single-prolonged stress, which is a classical animal model for mimicking posttraumatic stress disorder. Methods: The single-prolonged stress-induced anxiety-like behavior and pain response were detected by the novelty suppressed feeding, marble burying, locomotor activity, von Frey, and acetone-induced cold allodynia tests in mice. The serum corticosterone levels and glucocorticoid receptor, protein kinase A, phosphorylated cAMP response element binding protein, and brain-derived neurotrophic factor expression were detected by enzyme-linked immunosorbent assay and immunoblot analyses. Results: trans-Resveratrol reversed single-prolonged stress-induced increased latency to feed and the number of marbles buried in the novelty suppressed feeding and marble burying tests, but did not significantly influence locomotion distance in the locomotor activity test. trans-Resveratrol also reversed single-prolonged stress-induced cold and mechanical allodynia. Moreover, single-prolonged stress induced abnormality in the limbic hypothalamus-pituitary-adrenal axis was reversed by trans-resveratrol, as evidenced by the fact that trans-resveratrol reversed the differential expression of glucocorticoid receptor in the anxiety- and pain-related regions. In addition, trans-resveratrol increased protein kinase A, phosphorylated cAMP response element binding protein, and brain-derived neurotrophic factor levels, which were decreased in mice subjected to single-prolonged stress. Conclusions: These results provide compelling evidence that trans-resveratrol protects neurons against posttraumatic stress disorder-like stress insults through regulation of limbic hypothalamus-pituitary-adrenal axis function and activation of downstream neuroprotective molecules such as protein kinase A, phosphorylated cAMP response element binding protein, and brain-derived neurotrophic factor expression.

Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors

“…Anxiety disorders aggravate the occurrence and development of LBP, and the relationship between LBP and anxiety has recently attracted growing attention 24,25 . Resveratrol apparently alleviated multiple stress‐induced anxiety‐related behaviors 26,27 . Could the antianxiety effect of resveratrol contribute to LBP relief?…”

A resveratrol derivative modulates TRH and TRH‐like peptide expression throughout the brain and peripheral tissues of male rats

“…32 Trans-resveratrol protects neurons against PTSD through regulation of limbic hypothalamus-pituitary-adrenal axis function and activation of neuroprotective molecules such as protein kinase A, phosphorylated cAMP response element-binding protein and brain-derived neurotrophic factor expression. 5 Antidepressant-like effect of trans-resveratrol involves the regulation of the central serotonin and noradrenaline levels and related MAO-A activities. 8 Treatment with PT increased STR levels of TRH-like peptides including Tyr-TRH, Phe-TRH and Val-TRH (Table 2 and Figure 2) which have antidepressant effects.…”

“…Resveratrol and related polyphenols such as pterostilbene (PT) have therapeutic effects ranging from treatment of depression and anxiety, 1 , 2 , 3 , 4 , 5 stress, 6 , 7 , 8 PTSD, 5 epilepsy, 9 , 10 Alzheimer's and Parkinson's disease, 11 , 12 , 13 diabetes, 13 , 14 obesity, 15 cancer, 16 , 17 , 18 traumatic brain injury, 5 Huntington's disease, 19 hypertension, 20 pain, 5 , 21 neurodegeneration 22 , 23 , 24 , 25 and ageing. 19 , 26 , 27 , 28 , 29 , 30 Resveratrol upregulates mitochondria‐located antioxidant enzymes and triggers mitochondrial biogenesis.…”

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

“…Autophagy starts in reaction to chemical stresses, which may reduce therapeutic effectiveness [ 115 ]. This is especially essential when looking for ways to induce apoptosis in cancer cells [ 116 ].…”