<i>trans</i>‐resveratrol alone and hydroxystilbenes of rhubarb (<i>Rheum rhaponticum</i> L.) root reduce liver damage induced by chronic ethanol administration: a comparative study in mice

Raal, Ain; Pokk, Paavo; Arend, Andres; Aunapuu, Marina; Jõgi, J.; Õkva, Kai; Püssa, Tõnu

doi:10.1002/ptr.2665

Cited by 31 publications

(13 citation statements)

References 44 publications

(40 reference statements)

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“…A review documents evidence for the favorable effect entailing destruction of cancer-initiating ROS by AO action (see Introduction). Liver damage caused by chronic alcohol consumption was reduced by RVT 223. Inhibition of oxidation of polyunsaturated fatty acids is proposed as a basis of the hepatoprotective effect.…”

Section: Livermentioning

confidence: 99%

Multifaceted Approach to Resveratrol Bioactivity: Focus on Antioxidant Action, Cell Signaling and Safety

Kovacic

Somanathan

2010

Oxidative Medicine and Cellular Longevity

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Resveratrol (RVT) is a naturally occurring trihydroxy stilbene that displays a wide spectrum of physiological activity. Its ability to behave therapeutically as a component of red wine has attracted wide attention. The phenol acts as a protective agent involving various body constituents. Most attention has been given to beneficial effects in insults involving cancer, aging, cardiovascular system, inflammation and the central nervous system. One of the principal modes of action appears to be as antioxidant. Other mechanistic pathways entail cell signaling, apoptosis and gene expression. There is an intriguing dichotomy in relation to pro-oxidant property. Also discussed are metabolism, receptor binding, rationale for safety and suggestions for future work. This is the first comprehensive review of RVT based on a broad, unifying mechanism.

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Section: Livermentioning

confidence: 99%

Multifaceted Approach to Resveratrol Bioactivity: Focus on Antioxidant Action, Cell Signaling and Safety

Kovacic

Somanathan

2010

Oxidative Medicine and Cellular Longevity

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“…As one of the most famous medicinal herbs, rhubarb (Radix et Rhizome Rhei) is widely used in oriental medicine in Asian countries, and it is also an ingredient in numerous medicinal remedies of the ancient Greeks and Romans. Many recent studies have also revealed that rhubarb has antibacterial (Wang et al, 2010), anticancer (Shia et al, 2011a), anti-inflammation (Moon et al, 2006) and life-protecting effects (Raal et al, 2009). In addition, recent clinical trials demonstrated that rhubarb could significantly improve the endothelial function of the brachial artery (Liu et al, 2007) and ameliorate intestinal permeability (Fang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract

Yan

Yao

et al. 2013

Biomedical Chromatography

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A sensitive and specific LC-MS/MS method was developed for simultaneous determination of aloe-emodin, rhein, emodin, chrysophanol and physcion and their conjugates in rat plasma. The lower limit of quantitation of each anthraquinone was 0.020-0.040 µm. Intra-day and inter-day accuracies were 90.1-114.3% and the precisions were <14.6%. The matrix effects were 104.0-113.2%. The method was successfully applied to a pharmacokinetic study in rats receiving a rhubarb extract orally. The area under the concentration-time curve (AUC0-t ) and peak concentration (Cmax ) of free aloe-emodin and emodin in rat plasma were much lower than those of rhein. The amounts of chrysophanol and physcion were too low to be continuously detected. After treating the plasma samples with β-glucuronidases, each anthraquinone was detectable throughout the experimental period (36 h) and showed much higher plasma concentrations and AUC0-t . The free/total ratios of aloe-emodin, rhein and emodin were 6.5, 49.0 and 1.7% for Cmax and 3.7, 32.5 and 1.1% for AUC0-t , respectively. The dose-normalized AUC0-t and Cmax of the total of each anthraquinone were in the same descending order: rhein > emodin > chrysophanol > physcion > aloe-emodin. These findings reveal phase II conjugates as the dominant in vivo existing forms of rhubarb antharquinones and warrant a further study to evaluate their contribution to the herbal activity.

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“…With its antioxidant and anti‐inflammatory effects, there have been numerous studies on the prevention and treatment of hepatotoxicity due to various drugs and toxins about resveratrol. It has been shown to exhibit protective properties in hepatotoxicity developing in association with various agents, such as paracetamol, carbon tetrachloride (CCl 4 ) and alcohol . In addition to the preclinical in vitro and in vivo studies, recent studies including systematic reviews have demonstrated that resveratrol provides liver protection against cholestatic, drug‐ and alcohol‐induced injury.…”

Section: Objectivementioning

confidence: 99%

A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha‐Amanitin‐Induced Hepatotoxicity

Şahin

Arıcı

Yılmaz

et al. 2018

Basic Clin Pharma Tox

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Amanita phalloides species mushrooms containing alpha-amanitin (α-AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of α-AMA-induced hepatotoxicity. We investigated the effects of resveratrol on α-AMA-induced hepatotoxicity and compared with silibinin, a known antidote using in vivo and in vitro toxicity models. In the in vivo protocol, resveratrol (30 mg/kg) was given simultaneously with α-AMA (α-AMA + SR) or 12 (α-AMA + 12R) or 24 (α-AMA + 24R) hr after α-AMA administration. Silibinin (5 mg/kg) (α-AMA + Sil) and normal saline (α-AMA + NS) were given simultaneously with α-AMA. We found that liver transaminase levels in α-AMA + SR and α-AMA + 12R groups and histomorphologic injury score in the α-AMA + SR, α-AMA + 12R, α-AMA + 24R and α-AMA + Sil groups were significantly lower than that of the α-AMA + NS group. Resveratrol decreased mononuclear cell infiltration, necrosis and active caspase-3 immunopositivity in the liver. In the in vitro protocol, the effects of resveratrol and silibinin were evaluated in a reduction in cell viability induced by α-AMA in THLE-2 and THLE-3 hepatocytes. Neither resveratrol nor silibinin was found to be effective in increasing cell viability decreased by α-AMA + NS. As a conclusion, resveratrol was found to be effective in α-AMA-induced hepatotoxicity with its anti-inflammatory properties in in vivo conditions. It is a promising compound with the potential for use in the treatment of hepatotoxicity associated with Amanita phalloides type mushroom poisonings.

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trans‐resveratrol alone and hydroxystilbenes of rhubarb (Rheum rhaponticum L.) root reduce liver damage induced by chronic ethanol administration: a comparative study in mice

Cited by 31 publications

References 44 publications

Multifaceted Approach to Resveratrol Bioactivity: Focus on Antioxidant Action, Cell Signaling and Safety

Multifaceted Approach to Resveratrol Bioactivity: Focus on Antioxidant Action, Cell Signaling and Safety

Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract

A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha‐Amanitin‐Induced Hepatotoxicity

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