Abstract:Spermatogenesis comprises a coordinated process, including meiosis, to produce fertile male gametes. Previous study reported that Topaz1 is a germ cell specific gene highly conserved in vertebrates. Topaz1 knockout male mice are sterile. The mutant testes lack haploid germ cells and meiosis arrests at the first-division prophase-metaphase transition. Here, in order to better characterize the testicular phenotype of Topaz1-/- mice, we used RNA-seq analyses at two different developmental stages. At postnatal day… Show more
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