<i>Toona sinensis</i>Leaf Aqueous Extract Improves the Functions of Sperm and Testes via Regulating Testicular Proteins in Rats under Oxidative Stress

Yu, Bu Chin; Wen, Yongning; Huang, Ching Jer; Chen, Ying Hsin; Tsai, Yun; Chang, Chen Chin; Chang, Shang‐Jen

doi:10.1155/2012/681328

Cited by 8 publications

(6 citation statements)

References 23 publications

(38 reference statements)

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“…In 2005, results of Poon et al (2005) suggested that TSL could increase the motility of sperms via suppressing steroidogenesis, cAMP-PKA pathway and steroidogenic enzymes activities in normal mouse leydig cells. Furthermore, another paper also reported TSL could improves the functions of sperm and testes via downregulation of glutathione transferase mu6, heat shock protein 90 kDa-␤, cofilin 2 and cyclophilin A, whereas up-regulation of crease3-hydroxy-3-methylglutaryl-coenzyme A synthase 2, heat shock glycoprotein 96, and pancreatic trypsin 1 (Yu et al, 2012b). These findings suggest T. sinensis is a valuable agent for men to ameliorate functions of sperm and testes under oxidative stress.…”

Section: Male Reproductive System Protectionmentioning

confidence: 87%

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Peng

Liu

et al. 2019

Revista Brasileira de Farmacognosia

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a b s t r a c tToona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discussed in the corresponding parts of this paper, and perspectives for possible future studies of this plant are discussed. The main constituents of T. sinensis are terpenoids, phenylpropanoids and flavonoids, etc., and its pharmacological activities include anti-tumor effects, antioxidant activities, anti-diabetic effects and anti-inflammatory effects. Although a series of phytochemical and pharmacological researches of this plant have been conducted, the active constituents and action mechanism of these activities should be also further explored. Furthermore, the present review also indicates that T. sinensis has potentials to develop into drugs for treating various diseases with high efficacy and low toxicity, particularly in cancer, diabetes and inflammatory disorders. In conclusion, the paper provides a full-scale profile of the traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis, and also provides potential therapeutic uses and drug development prospects of this plant.

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Section: Male Reproductive System Protectionmentioning

confidence: 87%

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Peng

Liu

et al. 2019

Revista Brasileira de Farmacognosia

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“…While the underlying pharmacological mechanisms of TS remain unclear, various biological activities of TS leaf extracts have been reported. Recent scientific investigations demonstrated that aqueous leaf extracts of TS possess a variety of biological activities, including antioxidant, anticancer, anti-inflammation, antidiabetes, and antiangiogenesis effects, as well as the ability to inhibit Leydig cell steroidogenesis and improve the quality and dynamic activity of human sperm [ 15 – 18 ]. The safety levels and nontoxic characteristics of TS were evaluated using acute and subacute toxicity studies in mice and rats, and no lethal effects were found at concentrations as high as 1 g/kg body weight [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Toona sinensisInhibits LPS-Induced Inflammation and Migration in Vascular Smooth Muscle Cells via Suppression of Reactive Oxygen Species and NF-κB Signaling Pathway

Yang

Huang

Liu

et al. 2014

Oxidative Medicine and Cellular Longevity

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Toona sinensis is one of the most popular vegetarian cuisines in Taiwan and it has been shown to possess antioxidant, antiangiogenic, and anticancer properties. In this study, we investigated the antiatherosclerotic potential of aqueous leaf extracts from Toona sinensis (TS; 25–100 μg/mL) and its major bioactive compound, gallic acid (GA; 5 μg/mL), in LPS-treated rat aortic smooth muscle (A7r5) cells. We found that pretreatment with noncytotoxic concentrations of TS and GA significantly inhibited inflammatory NO and PGE2 production by downregulating their precursors, iNOS and COX-2, respectively, in LPS-treated A7r5 cells. Furthermore, TS and GA inhibited LPS-induced intracellular ROS and their corresponding mediator, p47phox. Notably, TS and GA pretreatment significantly inhibited LPS-induced migration in transwell assays. Gelatin zymography and western blotting demonstrated that treatment with TS and GA suppressed the activity or expression of MMP-9, MMP-2, and t-PA. Additionally, TS and GA significantly inhibited LPS-induced VEGF, PDGF, and VCAM-1 expression. Further investigation revealed that the inhibition of iNOS/COX-2, MMPs, growth factors, and adhesion molecules was associated with the suppression of NF-κB activation and MAPK (ERK1/2, JNK1/2, and p38) phosphorylation. Thus, Toona sinensis may be useful for the prevention of atherosclerosis.

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“…TSL aqueous extracts repressed the ROS level, maintained the mitochondrial membrane potential (MMP) and restored sperm motility to improve sperm and testicular function under oxidative stress [96]. Studies have shown that increased levels of oxidative stress may be one of the main causes of decreased semen quality.…”

Section: Effects On the Male Reproductive Systemmentioning

confidence: 99%

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Zhao,

Li,

Wang

et al. 2024

Molecules

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Toona sinensis (A. Juss.) Roem., which is widely distributed in China, is a homologous plant resource of medicine and food. The leaves, seeds, barks, buds and pericarps of T. sinensis can be used as medicine with traditional efficacy. Due to its extensive use in traditional medicine in the ancient world, the T. sinensis plant has significant development potential. In this review, 206 compounds, including triterpenoids (1–133), sesquiterpenoids (134–135), diterpenoids (136–142), sterols (143–147), phenols (148–167), flavonoids (168–186), phenylpropanoids (187–192) and others (193–206), are isolated from the T. sinensis plant. The mass spectrum cracking laws of representative compounds (64, 128, 129, 154–156, 175, 177, 179 and 183) are reviewed, which are conducive to the discovery of novel active substances. Modern pharmacological studies have shown that T. sinensis extracts and their compounds have antidiabetic, antidiabetic nephropathy, antioxidant, anti-inflammatory, antitumor, hepatoprotective, antiviral, antibacterial, immunopotentiation and other biological activities. The traditional uses, chemical constituents, compound cracking laws and pharmacological activities of different parts of T. sinensis are reviewed, laying the foundation for improving the development and utilization of its medicinal value.

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Toona sinensisLeaf Aqueous Extract Improves the Functions of Sperm and Testes via Regulating Testicular Proteins in Rats under Oxidative Stress

Cited by 8 publications

References 23 publications

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Toona sinensisInhibits LPS-Induced Inflammation and Migration in Vascular Smooth Muscle Cells via Suppression of Reactive Oxygen Species and NF-κB Signaling Pathway

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

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