<i>Tintelnotia,</i> a new genus in <i>Phaeosphaeriaceae</i> harbouring agents of cornea and nail infections in humans

Ahmed, Sarah; Hofmüller, Wolfram; Seibold, Michael; Hoog, G.S. de; Harak, H.; Tammer, Ina; Diepeningen, A.D. van; Behrens–Baumann, W.

doi:10.1111/myc.12588

Cited by 32 publications

(20 citation statements)

References 43 publications

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“…Members of Phaeosphaeriaceae are pathogens or hyper-parasites on living plants and humans and saprobes of decaying plant matter (Tennakoon et al 2016; Ahmed et al 2017). …”

Section: Introductionmentioning

confidence: 99%

Sulcispora supratumida sp. nov. (Phaeosphaeriaceae, Pleosporales) on Anthoxanthum odoratum from Italy

Senanayake

Jeewon

Camporesi³

et al. 2018

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Sulcispora is typified by S.pleurospora. We collected a sulcispora-like taxon on leaves of Anthoxanthumodoratum L. in Italy and obtained single ascospore isolates. Combined ITS, LSU, SSU and tef1 sequence analyses suggested that Sulcispora is placed in the family Phaeosphaeriaceae and a newly collected Sulcispora species is introduced here as S.supratumida sp. nov. Detailed descriptions and illustrations are provided for Sulcisporasupratumida and it is compared with the type species, S.pleurospora.

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“…Members of Phaeosphaeriaceae are pathogens or hyper-parasites on living plants and humans and saprobes of decaying plant matter (Tennakoon et al 2016; Ahmed et al 2017). …”

Section: Introductionmentioning

confidence: 99%

Sulcispora supratumida sp. nov. (Phaeosphaeriaceae, Pleosporales) on Anthoxanthum odoratum from Italy

Senanayake

Jeewon

Camporesi³

et al. 2018

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Section: Discussionmentioning

confidence: 99%

“…In the last few years, coelomycetous fungi have become of greater clinical importance as opportunistic pathogens and being more commonly identified in clinical laboratories. 5,[37][38][39] Although identification by molecular assays is now easier and more available for clinical laboratories, misidentification of these fungi still occurs since they do not sporulate and there are not enough ITS sequences in the public databases for comparisons. For this reason, more taxonomic studies providing further molecular data are necessary so that the clinicians have a more accurate identification when morphological analysis is not possible, as often occurs with the genera Phoma and Pyrenochaeta, for example.…”

Section: Discussionmentioning

confidence: 99%

Two new species of Gloniopsis (Hysteriales, Ascomycota) from clinical specimens: Morphological and molecular characterisation

Valenzuela-López

Magaña-Dueñas

Cano-Lira

et al. 2019

Mycoses

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Summary Background The coelomycetes comprise a wide range of fungal species distributed in at least three different classes of the phylum Ascomycota. These are morphologically characterised by producing their conidia inside of fruiting bodies called pycnidia or acervuli, and only a reduced number of species are able to cause human infections. However, their identification in the clinical laboratory is often difficult, due to their few morphological features or because they remain sterile. Materials and Methods In the present study, three isolates of coelomycetes of clinical origin were phenotypically and molecularly studied, by sequencing the D1‐D2 fragment of the 28S nuclear ribosomal RNA (nrRNA) (LSU), the internal transcribed spacer region (ITS1‐5.8S‐ITS2) and a fragment of the translation elongation factor 1‐alpha (tef1) genes. Results and Conclusions As result of the molecular analysis, the isolates were identified as belonging to the genus Gloniopsis (order Hysteriales, Dothideomycetes) but without the characteristics of any of the species described so far. Therefore, we propose the new species Gloniopsis percutanea and Gloniopsis pneumoniae. Furthermore, this study revealed that some isolates from clinical specimens identified previously as Rhytidhysteron spp. were misidentified, and considering the few studies in the order Hysteriales and the scarce number of sequences of phylogenetic markers, future revisions of this order should be performed to clarify their taxonomy and obtain a better identification from isolates involved in human mycoses.

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“…Recently, Ahmed et al (40) proposed Tintelnotia destructans , a new phoma-like fungus belonging to the Phaeosphaeriaceae able to cause eye and nail infections. They reported the successful use of terbinafine against a case of keratitis by this species.…”

Section: Discussionmentioning

confidence: 99%

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

García-Hermoso

Valenzuela-López

Rivero-Menéndez

et al. 2018

Preprint

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25The coelomycetous fungi are difficult to properly identify from their phenotypic 26 characterization and their role as etiologic agents of human infections is not clear. We 27 studied the species distribution of these fungi among clinical isolates that had been 28 collected and stored over a ten-year period in two European reference laboratories 29 (France and Spain). We identified phenotypically and molecularly 97 isolates by 30 sequencing the D1-D2 fragment of the 28S nrRNA (LSU) gene. Species of the orders 31 Pleosporales and Glomerellales were present in both collections, and Botryosphaeriales 32 and Diaporthales only in the French one. The most prevalent species were Medicopsis 33 romeroi, Neocucurbitaria keratinophila, Neocucurbitaria unguis-hominis and 34 Paraconiothyrium cyclothyrioides, which had been recovered primarily from superficial 35 tissues. The Didymellaceae was the most common family represented, with 27 isolates 36 distributed into five genera. 37 38 40 41 Human infections by coelomycetous fungi are rare and poorly characterized due 42 to the difficulty in identifying these fungi using only phenotypic tools. The 43 coelomycetous fungi are characterized by the production of conidia into fruiting bodies 44 (= conidiomata), and were originally included in the orders Sphaeropsidales and 45 Melanconiales of the class Coelomycetes, taxa which today lack scientific validity due 46 to the demonstrated polyphyletic character of this sort of fungus (1-3). They cause 47 superficial or subcutaneous infections, mostly following a traumatic inoculation of 48 contaminated plant material or soil particles during agricultural work in tropical and 49 subtropical areas (4-6). The most common coelomycetous fungi involved in these 50 infections are the etiologic agents of black-grain eumycetoma, such as Biatriospora 51 mackinnonii; Falciformispora spp., Medicopsis romeroi, and 52 Pseudochaetosphaeronema larense. Other common coelomycetous fungi include 53 Lasiodiplodia theobromae and Neoscytalidium dimidiatum (synanamorph of 54 Hendersonula toruloidea) (7-11), which typically cause onychomycosis, subcutaneous 55 phaeohyphomycosis (12-15), and eumycetoma (16). In addition, many species of 56 Phoma and Pyrenochaeta have been reported as occasional agents of localized and 57 systemic infections in humans (9, 17-20). The taxonomy of several coelomycetous 58 genera mentioned before have been revised recently but they still constitute a group of 59 highly polyphyletic taxa that are usually difficult to identify phenotypically (2, 21-24). 60 In a recent study conducted in the USA, Valenzuela-Lopez et al. (6) identified 61 230 fungal strains by sequencing the D1-D2 domains of the 28S rRNA gene (LSU), 62 from which 152 (66.1%) strains belonged to the order Pleosporales, the rest being 63 distributed in several orders of the phylum Ascomycota. Most of these strains were 64 recovered from superficial tissue. Neoscytalidium dimidiatum, Paraconiothyrium 65 cyclothyrioides and members of the family Didymellaceae were the most...

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Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans

Cited by 32 publications

References 43 publications

Sulcispora supratumida sp. nov. (Phaeosphaeriaceae, Pleosporales) on Anthoxanthum odoratum from Italy

Sulcispora supratumida sp. nov. (Phaeosphaeriaceae, Pleosporales) on Anthoxanthum odoratum from Italy

Two new species of Gloniopsis (Hysteriales, Ascomycota) from clinical specimens: Morphological and molecular characterisation

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

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