<i>The Home-life of the Osprey</i>
            . By Clinton G. Abbott. London, Witherby &amp; Co. 1911. Pp. 1-56; 32 mounted plates.

Herrick, Francis H.

doi:10.1126/science.35.907.780

Cited by 24 publications

(37 citation statements)

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“…19 Ideally, all biomedical devices should be able to prevent bacterial colonization on their surfaces, especially within the first 6 h of blood exposure, which is identified to be the most susceptible and most "decisive period" for the success of a long-term implant. 20 Thrombus and bacteria biofilm formation cause device failure, which in many cases can only be solved by device removal and replacement. Besides patients suffering, the increased healthcare costs associated with these infections has also created a significant economic burden.…”

Section: Mark E Meyerhoffmentioning

confidence: 99%

“…Besides patients suffering, the increased healthcare costs associated with these infections has also created a significant economic burden. 20 The clinical problems of thrombus and infection described above have triggered substantial interest among scientists to develop new and more effective ways to create antithrombotic and antibacterial polymeric surfaces for biomedical devices, especially those in direct contact with blood (e.g., intravascular catheters, vascular grafts, etc. ).…”

Section: Mark E Meyerhoffmentioning

confidence: 99%

“…Nitric oxide (NO), a diatomic free radical, was identified as the endothelium-derived relaxation factor (EDRF) in the Nobel Prize-winning discovery by Ignarro, Furchgott, and Murad in 1987. 20,[109][110][111][112][113][114] Many researchers have later unveiled NO's various physiological functions in the human body, including preventing platelet activation and adhesion, inhibiting bacterial proliferation and biofilm formation, enhancing endothelization, signaling in the immune system's response, and promoting angiogenesis and the wound healing process. 113,[115][116][117][118] The human body synthesizes a large quantity of bio-regulatory NO from the substrate L-arginine via three distinct isoforms of nitric oxide synthase (NOS), including endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).…”

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

“…First, NO can react with superoxide (O 2 − ) 128 and form peroxynitrite (OONO − ), which is a lethal oxidizing agent and can induce oxidative stress, nitrosate amino acids and thereby alter protein functionality, oxidize and break DNA strands, and cause cell membrane damage to the bacteria it comes in contact with via lipid peroxidation. 20,[128][129][130] A second possible route reported for NO mediated cytotoxicity relies upon the formation of S-nitrosothiols (RSNO) in which after oxidation of NO to N 2 O 3 the N 2 O 3 can react with sulfhydryl groups on cysteine residues of membrane proteins to create RSNO structures that alter protein functionality, leading to cell stasis or cell death. 109 Indeed, NO released or generated from polymer matrices has been shown to have similar antiplatelet and antimicrobial effects, as further described in detail below.…”

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

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Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

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Section: Mark E Meyerhoffmentioning

confidence: 99%

Section: Mark E Meyerhoffmentioning

confidence: 99%

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

See 2 more Smart Citations

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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“…13 Under these circumstances, implant removal and replacement represent the only viable option to eradicate the infection, although the risk of a relapse remains high. 14 In order to encounter peri-prosthetic infection, incorporation of Ag into HAp has been considered as a potential approach in providing long-term antibacterial ability. 15,16 Silver is a well-known effective bactericide over a wide range of bacteria including antibiotic-resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

et al. 2016

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The biocompatibility and antibacterial properties of hydroxyapatite (HAp) bioceramics are crucial in medical applications. However, it is still a challenge to control HAp with antibacterial ability while maintaining other biological properties in the development of bioactive bone implants. Herein, we report functional silver ion substituted HAp bioceramics with excellent osteoconductivity and efficient antibacterial activity and propose a stern-interface induced antibacterial mechanism of such bioactive ceramics. In this antibacterial process, the concentration of Ag(+) at the stern-interface of Ag/HAp bioceramics is nearly 5 times higher than that in the bulk solution due to the trace dopant Ag(+) enrichment in the stern layer of the electric double layer at the negatively charged surface of Ag/HAp bioceramics. Trace Ag-doping in HAp induces a positive shift of zeta potential and increase of hydrophilicity, which may help inhibit bacterial proliferation. The positive osteoblast adhesion, proliferation and differentiation of ultra-trace doped Ag/HAp are also demonstrated through actin cytoskeleton staining, MTT and alkaline phosphatase (ALP) activity assays. This work may enlighten us on the artificial design of novel smart anti-infective bone grafts using ultra-trace functional elements and also suggest its potential applications in orthopedic surgery and bone osseointegration.

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Self-Sterilizing Polymeric Membrane Sensors Based on 6-Chloroindole Release for Prevention of Marine Biofouling

Jiang

Hou

et al. 2020

Anal. Chem.

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A self-sterilizing strategy based on antimicrobial organic agent release is proposed for polymeric membrane sensors to prevent marine biofouling. A solid-contact polymeric membrane calcium ion-selective electrode (Ca 2+ -ISE) is selected as a model sensor. 6-Cholorindole (6-Cl indole) is utilized as the biocidal agent due to its potential antimicrobial activity and environmental friendliness. The plasticized polymeric membrane doped with 6-Cl indole shows a markedly improved antimicrobial activity against the bacterial cells collected from seawater and effectively prevents the formation of a biofilm on the sensor surface, while displaying response properties (i.e., linear range, selectivity, and response time) similar to those of the undoped membrane. Importantly, the present sensor can preserve an improved antimicrobial activity when kept in the artificial seawater for 45 days, indicating highly stable antibacterial properties of the membrane electrode. Additionally, the 6-Cl indole-doped Ca 2+ -ISE exhibits no significant loss of analytical performance after exposure to a rather concentrated bacterial suspension (∼10 9 colony-forming units per mL (CFU mL −1 )) for 7 days. The proposed antimicrobial agent release methodology can be extended to develop polymeric membrane-based marine sensors with stable biofouling resistances against bacterial colonization.

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The Home-life of the Osprey . By Clinton G. Abbott. London, Witherby & Co. 1911. Pp. 1-56; 32 mounted plates.

Cited by 24 publications

References 0 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

Self-Sterilizing Polymeric Membrane Sensors Based on 6-Chloroindole Release for Prevention of Marine Biofouling

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