The American Journal of Physiology-Heart and Circulatory Physiology: a long history, a bright future

Abstract

IN 1887 AFTER THE CIVIL WAR, the American Physiological Society (APS) was founded by five clinician scientists (12). Silas Weir Mitchell was, by training, a neurologist, and Henry Pickering Bowditch was a cardiovascular physiologist who had trained in Germany with Carl Ludwig. They joined Henry Newell Martin, an Irish-born cardiovascular physiologist from Johns Hopkins; Russell Henry Chittenden, a biochemist from Yale; and John Green Curtis, a surgeon from Columbia University. The first issue of The American Journal of Physiology (AJP) was published in 1898. Over the past 116 years, seminal and critically important experimental physiological studies have been published in AJP and its many subsections (16). These studies formed the basis, in many cases, for modern medicine and therapeutics. In 1977, AJP was divided into separate discipline-related journals, and thus the American

Priming mobilized peripheral blood mononuclear cells with the “activated platelet supernatant” enhances the efficacy of cell therapy for myocardial infarction of rats

“…Many trials have been done in the bench and at the bedside, leaving promising results . In the case of MI, one of the most promising benefits of cell therapy is the potential for cardiac tissue regeneration to reverse the tissue loss underlying the development of heart failure after cardiac injury . Despite this new era opened by cell therapy, the low efficacy has limited its potential as a therapeutic tool .…”

“…14,16 In the case of MI, one of the most promising benefits of cell therapy is the potential for cardiac tissue regeneration to reverse the tissue loss underlying the development of heart failure after cardiac injury. 17 Despite this new era opened by cell therapy, the low efficacy has limited its potential as a therapeutic tool. 14 Clinical meta-analyses have reported a modest 3% improvement (range 1.9% to 4.5%) in left ventricle ejection fraction, indicating that transition to the clinic may have occurred too quickly.…”

Combining Machine Learning and Blind Estimation for Central Aortic Blood Pressure Reconstruction

“…One of the vital signals that carry medical information about cardiovascular system conditions is the central blood pressure signals [1], [2]. The clinical protocols of measuring this signal are usually burdensome as they can only be measured invasively with a catheter.…”