<i>TGF-β1</i> Genotype in Pediatric Migraine Patients

Saygı, Semra; Alehan, Füsun; Erol, İlknur; Yalçın, Yaprak Yılmaz; Ataç, Fatma Belgin; Kubat, Gözde

doi:10.1177/0883073814527163

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…Plasma level of TGFB1 has been shown to increase in patients with migraine during headache-free periods compared to healthy subjects without headache 34 . Another study investigated the TGFB1 genotype in pediatric migraine patients and reported significant differences between control and migraine patients 35 . Our DEPICT gene analysis also prioritized JAG1 at the novel 20p12 migraine-associated locus.…”

Section: Discussionmentioning

confidence: 99%

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

et al. 2021

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Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility.

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Section: Discussionmentioning

confidence: 99%

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

et al. 2021

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“…The specific expression patterns of MCP-1, IL-10, TGF-beta, and other cytokines have also been linked with migraine disease development [ 37 , 38 ]. Furthermore, Saygi et al suggested that TGF-beta 1 genotypes are associated with pediatric migraine development [ 39 ]. This raises the possibility that hsa_circRNA_000367 and hsa_circRNA_102413 may modulate migraine pathogenesis via regulating the expression of these and other inflammatory factors, although further experiments will be needed to confirm this possibility.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients

Lin

Shi

Chen

et al. 2020

BioMed Research International

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Background. CircRNAs are noncoding RNA molecules that have recently been described and shown to regulate miRNA functionality. While recent studies have suggested such circRNAs to be associated with pain related diseases in humans, no comprehensive migraine-related circRNA profiles have been generated, and there is currently no clear understanding of whether they can serve as regulators of migraine pathology. Methods. We initially conducted a circRNA microarray analysis of the plasma of migraine patients and healthy controls. Based upon these data, we then selected 8 differentially expressed circRNAs and confirmed their expression in more migraine patient plasma samples via real-time PCR. We then performed functional and pathway enrichment analyses. Lastly, using a robust rank aggregation approach, we constructed a ceRNA network according to predicted circRNA–miRNA and miRNA–mRNA pairs in these migraine patient samples. Results. We were able to detect 2039 circRNAs in our patient samples, with 794 of 1245 these circRNAs being up- and downregulated in migraine patients relative to controls, respectively ( fold change ≥ 1.5 , p < 0.01 ). A qRT-PCR analysis confirmed that the expression of hsa_circRNA_100236, hsa_circRNA_102413, and hsa_circRNA_000367 was significantly enhanced in migraine patients, whereas the expression of hsa_circRNA_103809, hsa_circRNA_103670, and hsa_circRNA_101833 was significantly reduced in these individuals relative to healthy controls. We found these differentially regulated circRNAs to be associated with numerous predicted biological processes, with enrichment analyses suggesting that they may modulate the PI3K-Akt signaling so as to promote inflammation to drive migraine development. However, further research will be needed to formally test these mechanistic possibilities and to validate these circRNAs as potential biomarkers of migraine patients. Conclusions. Our results offer new potential insights into the mechanistic basis of this condition and suggest that hsa_circRNA_000367 and hsa_circRNA_102413 may offer value as regulators of migraine pathology.

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“…5 In keloids patients, TGF-β1 stimulates keloid fibroblast proliferation and collagen 12 reported that TGF-β1 levels in cerebrospinal fluid cytokines were higher in patients with migraines compared with a control group of patients without migraines. Saygi et al 13 further reported a significantly higher frequency of TGF-β1 polymorphisms in migraine patients compared with healthy controls. In Eiser, 14 TGF-β1 activation appeared to mediate morbidities associated with keloids in African-Americans.…”

Section: Risks Factors For Migraine In Keloids Groupmentioning

confidence: 94%

Migraines and keloids: a 15-year Taiwan claim database analysis

Qin

et al. 2021

Postgraduate Medical Journal

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BackgroundFibroproliferative lesions with intractable pruritus, pain and hyperesthesia that cause uncontrolled scar growth are known as keloids. Migraines are common upsetting headache disorders characterised by frequent recurrence and attacks aggravated by physical activity. Both keloids and migraines can cause physical exhaustion and discomfort in patients; they have similar pathophysiological pathways, that is, the transforming growth factor-β1 gene and neurogenic inflammation.ObjectiveTo investigate subsequent development of migraines in patients with keloids.MethodsData were retrieved from the Taiwan National Health Insurance Research Database. The keloids group included patients aged 20 years and older with a recent diagnosis of keloids(n=9864). The non-keloids group included patients without keloids matched for gender and age at 1–4 ratio (n=39 456). Migraine risk between groups was measured by Cox proportional hazards regression models. Incidence rates and hazard ratios were calculated.ResultsDuring the study period, 103 keloids patients and 323 non-keloids patients developed migraines. The keloids patients had a 2.29-fold greater risk of developing migraines compared with the non-keloids group after adjustment for covariates (1.81 vs 0.55 per 1000 person-years, respectively). In the keloids group, female or patients younger than 50 years were prone to developing migraines.ConclusionThe higher tendency to develop migraines in the keloids group in comparison with the non-keloids group suggests that keloids could be a predisposing risk factor for migraine development in adults. Keloids patients who complain of headaches should be examined for migraines.

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TGF-β1 Genotype in Pediatric Migraine Patients

Cited by 7 publications

References 28 publications

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients

Migraines and keloids: a 15-year Taiwan claim database analysis

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