Teucrium ramosissimum Derived-Natural Products and Its Potent Effect in Alleviating the Pathological Kidney Damage in LPS-Induced Mice

Abstract

Teucrium esssential oil mediates an extensive spectrum of biological effects, including renal diseases. The aim of this research was to explore the ethnobotanical feature, biochemical composition and antiinflammatory potential of T. ramosissimum alone or prior the use of LPS-induced kidney damage. The essential oils were subjected to Gas chromatography-mass spectrometry (GC/MS) apparatus to detect biomolecules in T. ramosissimum. In vivo renal dysfunction induced by LPS was investigated using mouse model. Our data showed that oral treatment of animals with LPS highly increased level of serum biomarkers and induces renal dysfuntion, whereas, pre-treatment with T. ramosissimum mediated markedly histopatological changes of kidney architecture and ameliorates renal function. Dense cover of secretory structures in teucrium leaves may protect this specie. Overall, this study showed phytocompounds richness and interesting biological activities of Tunisian Teucrium ramosissimum. Essential oil of this specie T. ramossimum given prior to LPS exposure protected mice from renal inflammation.