<i>Teucrium polium</i>
            extract‐loaded solid lipid nanoparticles: A design and in vitro anticancer study

Roumi, Sana; Tabrizi, Masoud Homayouni; Es‐haghi, Ali; Abbasi, Nafas

doi:10.1111/jfbc.13868

Cited by 7 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[56] Previous studies have also reported the improved apoptotic activity with solid lipid nanoparticle encapsulating various plant extracts such as teucrium polium extract loaded SLN demonstrated caspase mediated apoptosis in Ntra-2 cancer cells. [57] Similarly, a previous study reported the GLN loaded with docetaxel (DTX), imitinib (IMA) and quercetin (Qu). These loaded NP demonstrated improved apoptosis by enhancing the expression of apoptotic protein.…”

Section: Apoptosis and Genotoxicity Assessmentmentioning

confidence: 92%

“…Besides inducing reactive oxygen species (ROS) mediated apoptosis, BA extract also exhibited protective effect towards mitomycin C and cisplatin, as they induced mitochondrial dysfunction in the cell [56]. Previous studies have also reported the improved apoptotic activity with solid lipid nanoparticle encapsulating various plant extracts such as teucrium polium extract loaded SLN demonstrated caspase mediated apoptosis in Ntra-2 cancer cells [57]. Similarly, a previous study reported the GLN loaded with docetaxel (DTX), imitinib (IMA) and quercetin (Qu).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Green Synthesis of Gelatin‐Lipid Nanocarriers Incorporating Berberis aristata Extract for Cancer Therapy; Physical Characterization, Pharmacological and Molecular Modeling Analysis

et al. 2022

View full text Add to dashboard Cite

Cancer remains strongly associated with morbidity and lethality posing a massive challenge to public health from decades. Thus, new interventions, effective and meaningful therapeutic approaches towards the treatment of cancer are urgently required. In this regard, nanotechnology offers an efficacious pharmacological application towards anticancer therapy. Therefore, the current study was aimed to develop Berberis aristata aqueous extract loaded gelatin lipid-nanocarriers to explore their in vitro and in vivo antitumor properties. The extract loaded gelatin lipid nanoparticles were formulated by using double emulsion solvent evaporation method and physical characterization was performed using various techniques. Hydrodynamic diameter, zeta potential and polydispersity index (PDI) of GLN-BA were observed as 322 � 7 nm, À 31.49 � 4.85 mV and 0.397 � 0.102 mV, respectively. The extract was efficiently entrapped within the GLN (EE = 79 � 11 %) and follow the diffusion type release mechanism. Moreover, transmission electron microscopy (TEM) demonstrated the spher-ical shaped smooth morphology of nanospheres. In vitro anticancer activity of GLN-BA was performed by SRB assay and shown to demonstrate effective cytotoxicity (IC 50 = 4.73 � 2.95 μg/mL) against MCF-7 which was further quantitatively and qualitatively verified by flow cytometry, genotoxicity and DAPI staining. Induction of apoptotic bodies provides the evidence for apoptosis mediated cytotoxicity. Further, in vivo analysis on female mice was carried out to corroborate anticancer activity and was comparable to cisplatin. At 10 th day, the GLN-BA (10 mg/kg) prominently reduced the tumor volume to 35 � 11 % in consistent with cisplatin (3 mg/kg) which exhibited 41 � 5 % reduction. Moreover, molecular modeling analysis substantiates the stable nanoformulation encapsulating the BA bioactive constituent. Taken together, current findings supported the therapeutic effectiveness of BA encapsulated gelatin lipid nanoparticles towards breast cancer suggesting the use of medicinal plant as a prototype to treat tumor.

show abstract

Section: Apoptosis and Genotoxicity Assessmentmentioning

confidence: 92%

mentioning

confidence: 99%

Green Synthesis of Gelatin‐Lipid Nanocarriers Incorporating Berberis aristata Extract for Cancer Therapy; Physical Characterization, Pharmacological and Molecular Modeling Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In the homogenization process, melted lipids are mixed with drugs and a preheated aqueous phase containing surfactants. The mixture undergoes high-pressure homogenization for several cycles to achieve the desired nanoparticle size. , Alternatively, ultrasonication involves homogenizing the aqueous phase with surfactants and melted lipids using high-speed stirring, followed by ultrasonication to break down large particles into smaller droplets …”

Section: Lnp Synthesis Methodsmentioning

confidence: 99%

“…The mixture undergoes high-pressure homogenization for several cycles to achieve the desired nanoparticle size. 153,154 Alternatively, ultrasonication involves homogenizing the aqueous phase with surfactants and melted lipids using high-speed stirring, followed by ultrasonication to break down large particles into smaller droplets. 155 However, the nonsolvent emulsification technique involves complex procedures and multistep processes, leading to a potential batch-to-batch variation.…”

Section: Nonsolvent Emulsificationmentioning

confidence: 99%

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

Mehta,

Bui,

Yang

et al. 2023

ACS Mater. Au

View full text Add to dashboard Cite

Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential. We discuss computational studies and modeling techniques to enhance the understanding of how LNPs interact with therapeutic cargo and to predict the potential effectiveness of such interactions in therapeutic applications. We also analyze the benefits and drawbacks of various LNP production techniques such as nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, and an impingement jet mixer. Additionally, we discuss the major challenges associated with industrial development, including stability and sterilization, storage, regulatory compliance, reproducibility, and quality control. Overcoming these challenges and facilitating regulatory compliance represent the key steps toward LNP’s successful commercialization and translation into clinical settings.

show abstract

Lipid Nanoparticles for Drug Delivery

Wang

Liu

et al. 2021

Advanced NanoBiomed Research

186

110

View full text Add to dashboard Cite

Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as evidenced by the approval of two RNA therapies and mRNA COVID‐19 vaccines. In this review, an overview on different classes of lipid nanoparticles, including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, is first provided, followed by the introduction of their preparation methods. Then the characterizations of lipid nanoparticles are briefly reviewed and their applications in encapsulating and delivering hydrophobic drugs, hydrophilic drugs, and RNAs are highlighted. Finally, various applications of lipid nanoparticles for overcoming different delivery challenges, including crossing the blood–brain barrier, targeted delivery, and various routes of administration, are summarized. Lipid nanoparticles as drug delivery systems offer many attractive benefits such as great biocompatibility, ease of preparation, feasibility of scale‐up, nontoxicity, and targeted delivery, while current challenges in drug delivery warrant future studies about structure–function correlations, large‐scale production, and targeted delivery to realize the full potential of lipid nanoparticles for wider clinical and pharmaceutical applications in future.

show abstract

Teucrium polium extract‐loaded solid lipid nanoparticles: A design and in vitro anticancer study

Cited by 7 publications

References 53 publications

Green Synthesis of Gelatin‐Lipid Nanocarriers Incorporating Berberis aristata Extract for Cancer Therapy; Physical Characterization, Pharmacological and Molecular Modeling Analysis

Green Synthesis of Gelatin‐Lipid Nanocarriers Incorporating Berberis aristata Extract for Cancer Therapy; Physical Characterization, Pharmacological and Molecular Modeling Analysis

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

Lipid Nanoparticles for Drug Delivery

Contact Info

Product

Resources

About