TempEasy 3D Hydrogel Coculture System Provides Mechanistic Insights into Prostate Cancer Bone Metastasis
Zhaobao Zhang,
Wen Chen,
Mingchen Sun
et al.
Abstract:Patients diagnosed
with advanced prostate cancer (PCa) often experience
incurable bone metastases; however, a lack of relevant experimental
models has hampered the study of disease mechanisms and the development
of therapeutic strategies. In this study, we employed the recently
established Temperature-based Easy-separable (TempEasy) 3D cell coculture system to
investigate PCa bone metastasis. Through coculturing PCa and bone
cells for 7 days, our results showed a reduction in PCa cell proliferation,
an increas… Show more
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