TEL/AML1+ ACUTE LYMPHOBLASTIC LEUKEMIA IN THE GREEK PEDIATRIC POPULATION

Abstract

INTRODUCTION:Various pathways, such as personperson, fecal-oral, and oral-oral transmission, play a role in transmission of Helicobacter pylori infection. It can be transferred from mother to infant in either the perinatal or postnatal periods. OBJECTIVE: The aim of this prospective study was to determine the course of H pylori infection in motherinfant pairs in early years of life. METHODS: Forty-eight mother-child pairs were followed for 12 months. H pylori and hepatitis A virus immunoglobulin G levels were measured in maternal sera, infant sera, and breast-milk samples at birth and in breast-milk samples and infant sera at follow-up visits. RESULTS: At birth, the seropositivity for H pylori was 81.25% and hepatitis A was 68.75% in breast milk and 95.8% in maternal and infant sera for both microorganisms. Although there was a decrease in seropositivities for both agents in both infant sera and breast milk at the age of 9 months, an increase was observed in the twelfth month. CONCLUSIONS: High seroprevalence rates of H pylori and hepatitis A virus and similar monthly changes in seroprevalence could be indicators of the same transmission routes. IMPACT OF ZINC SUPPLEMENTATION ON GROWTH: A DOUBLE-BLIND, RANDOMIZED TRIAL AMONG URBAN IRANIAN SCHOOLCHILDREN Submitted by Nahid MasoodpoorNahideh Masoodpoor, R. Darakshan Rafsanjan Medical Hospital, Rafsanjan, Iran INTRODUCTION:The first study that linked zinc and growth was carried out in Iran and Egypt almost 3 decades ago. At the time, the circumstances leading to growth impairment secondary to zinc deficiency were believed to be unique in less developed countries. Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies have been inconsistent. OBJECTIVE: The aim of this study was to investigate the impact of zinc supplementation on growth (weight and height) among schoolchildren who were underweight or had stunted growth. METHODS: Our study was a randomized, double-blind, placebo-controlled trial of 90 Iranian urban schoolchildren (50 boys and 40 girls; 7-12 years old) who were underweight or stunted and were supplemented with 10 mg of zinc or placebo on school days for 6 months. Variables were weight and height.RESULTS: Significant effects on weight gain (2.037 Ϯ 1.240 vs 1.55 Ϯ 0.64 kg; P ϭ .0167) and height (2.030 Ϯ 1.003 vs 1.403 Ϯ 0.521 cm; P ϭ .0002) in the children after zinc supplementation versus placebo administration, respectively, were seen over the 6-month period. CONCLUSIONS: On the basis of this study, zinc supplementation improved growth in underweight or stunted children and should be considered for populations at risk for zinc deficiency, especially where there are elevated rates of underweight or stunting. In this study, we attempted to estimate the incidence and clinical features of TEL/AML1 ϩ ALL for the first time in a representative cohort of Greek pediatric patients. METHODS: One hundred twenty children (Ͻ16 years old) diagnosed with ALL (107 of B-cell origin, 13 of...

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

“…In United States this is estimated to be 17-25% among pediatric patients (Loh et al, 1998;Jamil et al, 2000). The incidence of TEL-AML1 fusion in 334 Italian and German children with ALL was 18.9% (Borkhardt et al, 1997) and 22-27% in German children alone (Papadhimitriou et al, 2008), as compared to 22.5% in 617 children from UK (Harrison, 2000). Similarly the prevalence of TEL-AML1 transcript in acute lymphoblastic leukemia patients in Serbia is 17.1% (Lazic et al, 2010) and 20% in Brazil (Magalhaes et al, 2000).…”