<i>TAS2R38</i> Bitterness Receptor Genetic Variation and Risk of Gastrointestinal Neoplasm: A Meta-Analysis

Choi, Jeong-Hwa; Kim, Jeongseon

doi:10.1080/01635581.2018.1559935

Cited by 9 publications

(15 citation statements)

References 35 publications

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“…For the hub gene TAS2R38, encoding bitterness taste receptor, influences the progression of adenomatous polyps by dietary vitamin C and folic acid (50). Other studies show that genetic variation in TAS2R38 is thought to be associated with gastrointestinal risks by modifying dietary intake (51,52). In our research, this gene is associated with the trait of overall survival and the mean methylation levels of TAS2R38 was lower in READ (Supplementary Figure 8C).…”

Section: Discussionsupporting

confidence: 62%

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

Shi

Zhang

et al. 2021

Front. Oncol.

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Malignancies of alimentary tract include esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). Despite of their similarities in cancer development and progression, there are numerous researches concentrating on single tumor but relatively little on their common mechanisms. Our study explored the transcriptomic data of digestive tract cancers from The Cancer Genome Atlas database, yielding their common differentially expressed genes including 1,700 mRNAs, 29 miRNAs, and 362 long non-coding RNAs (lncRNAs). There were 12 mRNAs, 5 miRNAs, and 16 lncRNAs in the core competitive endogenous RNAs network by RNA-RNA interactions, highlighting the prognostic nodes of SERPINE1, hsa-mir-145, and SNHG1. In addition, the weighted gene co-expression network analysis (WGCNA) illustrated 20 gene modules associated with clinical traits. By taking intersections of modules related to the same trait, we got 67 common genes shared by ESCA and READ and screened 5 hub genes, including ADCY6, CXCL3, NPBWR1, TAS2R38, and PTGDR2. In conclusion, the present study found that SERPINE1/has-mir-145/SNHG1 axis acted as promising targets and the hub genes reasoned the similarity between ESCA and READ, which revealed the homogeneous tumorigenicity of digestive tract cancers at the transcriptome level and led to further comprehension and therapeutics for digestive tract cancers.

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Section: Discussionsupporting

confidence: 62%

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

Shi

Zhang

et al. 2021

Front. Oncol.

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“…For instance, thyrocyte-expressed T2Rs regulate the production of triiodothyronine and thyroxin and are associated with the risk of papillary thyroid carcinoma [16,17]. The genetic variations in TAS2R38 also modified the risk of gastric and colorectal cancer [13,14,18]. Observational studies reported that those genetic variations were associated with body fatness.…”

Section: Introductionmentioning

confidence: 99%

Variation in the TAS2R38 Bitterness Receptor Gene Was Associated with Food Consumption and Obesity Risk in Koreans

Choi

2019

Nutrients

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Bitterness-sensing protein taste receptor type-2 member 38 (TAS2R38, T2R38) mediates taste perception and various physiological responses, including energy- and adiposity-related mechanisms. This study examined whether the genetic variant rs10246939 C > T in TAS2R38 was associated with food intake and body size as well as obesity risk. Data from the Korean Multi-Rural Communities Cohort study (1338 males and 2229 females) were analyzed to obtain the intake of six food groups, alcohol consumption, smoking status and anthropometric measurements, including height, weight, waist and hip circumference, and body mass index (BMI), according to the rs10246939 genotype. Findings suggested that females with the TT genotype consumed more fruit (adjusted p = 0.025) and had significantly higher body weights (adjusted p = 0.046) and BMIs (adjusted p = 0.003) than individuals with other genotypes. Having the TT genotype also increased the risk of obesity by 1.75-fold (95% confidence interval: 1.31–2.36) in females. The genetic variation had a minimal influence on the males’ dietary intake, but tended to increase the adiposity risk. In conclusion, TAS2R38 rs10246939 variation was associated with Koreans’ dietary intake and increased their risk of obesity. Although more detailed statistical analyses in the larger cohort are required, current study suggested that, as a genetic predictive marker, TAS2R38 bitterness receptor variations may have a large implication in obesity prevention and treatment.

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“…Several recent studies [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] have examined the role of bitter taste perception in cancer development, focusing on the question of whether genetic variations of TAS2Rs impact the risk for developing cancer directly as well as indirectly via different dietary intake caused by the gene-mediated variability of bitter taste sensitivity. Within the scientific community, the following hypotheses from different perspectives are discussed: (i) an increased bitterness perception leads to the avoidance of bitter-tasting foods with health-promoting phytochemicals and, as a consequence, increases cancer risk [ 36 , 38 ]; (ii) an elevated sensitivity of TAS2Rs to bitter-tasting compounds is protective against bitter-tasting carcinogenic compounds, leading to a decreased cancer risk [ 37 , 40 , 41 ]; (iii) cancer risk is influenced by genetic variants via TAS2R-related, tissue-specific functions [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Bitter Taste Receptors in Cancer: A Systematic Review

Zehentner

Reiner

Grimm

et al. 2021

Cancers

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Background: Since it is known that bitter taste receptors (TAS2Rs) are expressed and functionally active in various extra-oral cells, their genetic variability and functional response initiated by their activation have become of broader interest, including in the context of cancer. Methods: A systematic research was performed in PubMed and Google Scholar to identify relevant publications concerning the role of TAS2Rs in cancer. Results: While the findings on variations of TAS2R genotypes and phenotypes and their association to the risk of developing cancer are still inconclusive, gene expression analyses revealed that TAS2Rs are expressed and some of them are predominately downregulated in cancerous compared to non-cancerous cell lines and tissue samples. Additionally, receptor-specific, agonist-mediated activation induced various anti-cancer effects, such as decreased cell proliferation, migration, and invasion, as well as increased apoptosis. Furthermore, the overexpression of TAS2Rs resulted in a decreased tumour incidence in an in vivo study and TAS2R activation could even enhance the therapeutic effect of chemotherapeutics in vitro. Finally, higher expression levels of TAS2Rs in primary cancerous cells and tissues were associated with an improved prognosis in humans. Conclusion: Since current evidence demonstrates a functional role of TAS2Rs in carcinogenesis, further studies should exploit their potential as (co-)targets of chemotherapeutics.

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TAS2R38 Bitterness Receptor Genetic Variation and Risk of Gastrointestinal Neoplasm: A Meta-Analysis

Cited by 9 publications

References 35 publications

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

Variation in the TAS2R38 Bitterness Receptor Gene Was Associated with Food Consumption and Obesity Risk in Koreans

The Role of Bitter Taste Receptors in Cancer: A Systematic Review

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