<i>Tarantula cubensis</i>extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas

Gültiken, Nilgün; Güvenç, Tolga; Kaya, Doǧan; Ağaoğlu, Ali Reha; Ay, Serhan Serhat; Küçükaslan, İbrahim; Emre, Birten; Fındık, Murat; Schäfer-Somi, Sabine; Aslan, Selim

doi:10.4142/jvs.2015.16.2.213

Cited by 19 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also it is used for the treatment of in mammary tumours in dogs (7). It was reported that Tarantula cubensis extract increased the apoptotic mechanism in mammary tumour cells (7,8). As it was reported by Gültiken and Vural (9) that Tarantula cubensis extract stopped the growth and reduced the size of the tumour similar clinical findings were observed in this study.…”

Section: Discussionsupporting

confidence: 90%

An uncommon case in the domestic rabbit (Oryctolagus cuniculus): Mammary neoplasm

Küçükaslan

Ozturk

Ünver

2013

Reproductive Biology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

An uncommon case in the domestic rabbit (Oryctolagus cuniculus): Mammary neoplasm

Küçükaslan

Ozturk

Ünver

2013

Reproductive Biology

View full text Add to dashboard Cite

“…To explain the reason for the different levels of cytotoxicity between the normal and cancer cells, it was stated that the rapid metabolism rate of the cancer cells causes increased vulnerability against the extract. When Theranekron ® was tested on canine mammary tumors, immunohistochemical staining of these tumors revealed that Bcl-2 and Ki-67 expression levels were significantly affected after the Theranekron ® treatment [27]. Bcl-2 expression levels are crucial for apoptosis regulation, specifically for human breast cancer [28].…”

Section: Resultsmentioning

confidence: 99%

In vitro cytotoxic activity of Tarantula cubensis alcoholic extract on different human cell lines

Pulat

2021

Cumhuriyet Science Journal

View full text Add to dashboard Cite

Spider venoms are known to have great potential for their antimicrobial, antifungal, and antitumor activities due to their rich peptide content. Tarantula cubensis alcoholic extract Theranekron ® is a homeopathic remedy and it is frequently used in veterinary treatments. Specifically, the anti-inflammatory, antitumor and wound healing effects of Theranekron ® provide a wide range of use in animal treatments. More importantly, it can reduce the growth rate of canine mammary tumors. This effect shows that Theranekron ® can be a potential candidate for cancer treatment. In this study, the cytotoxic effect of Theranekron ® was evaluated in four different human cancer cell lines and one non-cancerous human cell line. It was aimed to provide a foundation for further studies by conducting an in vitro screening for the cytotoxic effect of Theranekron ® . Results showed that Theranekron ® has a high cytotoxic effect on human breast cancer cell lines. On the other hand, the rate of cytotoxicity was found to be relatively lower on human small cell lung cancer, glioblastoma and human prostate cancer cell lines as compared to breast cancer cells. These results indicated that T. cubensis alcoholic extract might be utilized as an anticancer bio-therapeutic and should be further examined for its potential.

show abstract

“…Due to a moderate improvement in the clinical condition and significant weight loss in such a short time, an experimental therapy was decided upon the consent of the owner. Theranecron (Tarantula cubensis extract) was introduced into the treatment based on the results of Guliken et al (2). The drug was injected subcutaneously once a week at a dose of 2.5 ml/dog.…”

Section: A Case Reportmentioning

confidence: 99%

Chemodectoma located in the left atrium in 11 month survival dog with the use of palliative therapy

Szaluś‐Jordanow¹,

Stabińska-Smolarz²,

Czopowicz³

et al. 2021

Medycyna Weterynaryjna

View full text Add to dashboard Cite

The aim of this study was to present a clinical case of chemodectoma located in the left atrium in a dog. Chemodectoma is a heart base tumor, neoplasms that occur in the proximity of major blood vessels. A presumptive diagnosis is made based on location and appearance of the tumor in echocardiography examination. In advanced diagnostics computed tomography (CT) and magnetic resonance imagining (MRI) are used. Final diagnosis is made mainly during autopsy based on histopatological examination or less commonly in veterinary medicine on a histopathological examination of the tissue taken during a biopsy or of the entire removed tumor. In literature few methods of treatment are presented, including surgery, chemotherapy and radiotherapy. In an 8-year-old male French bulldog a tumor in the left atrium was detected. The tumor filled almost the entire left atrium, additionally pericardial effusion and ascites were observed. For treatment, tarantula cubensis extract (Theranecron) was used. After the introduction of Theranecron the patient felt significantly better. Theranecron may be one of the possibilities of palliative therapy in the case of diagnosing inoperable chemodectoma.

show abstract

Tarantula cubensisextract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas

Cited by 19 publications

References 30 publications

An uncommon case in the domestic rabbit (Oryctolagus cuniculus): Mammary neoplasm

An uncommon case in the domestic rabbit (Oryctolagus cuniculus): Mammary neoplasm

In vitro cytotoxic activity of Tarantula cubensis alcoholic extract on different human cell lines

Chemodectoma located in the left atrium in 11 month survival dog with the use of palliative therapy

Contact Info

Product

Resources

About